US4798790A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Monoclonal antibody specific for a pigmentation associated antigen
Assignee: SLOAN-KETTERING INSTITUTE 1275 YORK AVENUE NEW YORK NEW YORK 10021 A NEW YORK CORP
•
Filing: 1985-07-18
•
Granted: 1989-01-17
•
Expires: 2005-07-18
Abstract
Abstract Monoclonal antibody TA99, which specifically binds to a pigmentation associated antigen present on melanoma cells is described. Additionally, the hybridoma cell line deposited with the ATCC under Accession Number HB 8704 from which the antibody is derived, as well as methods for using the antibody are described.
Inventors
- 👤 Timothy M. Thomson
- 👤 M. Jules Mattes
- 👤 Lloyd J. Old
- 👤 Kenneth O. Lloyd
- 👤 Linda Roux
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 23:15
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; Y; Y10; Y10S; Y10S436/00; Y10S436/811; Y10S436/813; Y10S530/00; Y10S530/808
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
16 words
A hybridoma cell line designated TA99 and deposited with the ATCC under Accession Number HB 8704.
Claim 2
Dependent Claim
16 words
A hybridoma cell line designated TA99 and deposited with the ATCC under Accession Number HB 8704.
Claim 3
Dependent Claim
12 words
A monoclonal antibody produced by the hybridoma cell line of claim 1.
Claim 4
Dependent Claim
11 words
A monoclonal antibody of claim 2 labeled with a detectable moiety.
Claim 5
Dependent Claim
61 words
A method of detecting a pigmentation associated antigen which weights about 70-80 kilodaltons and has an isoelectric point of about 5.2 to 5.6 comprising contacting a sample containing said antigen with the monoclonal antibody of claim 3 under conditions so as to form a complex between said antibody and said antigen and detecting the complex so formed, thereby detecting said antigen.
Claim 6
Dependent Claim
12 words
Method of claim 4, wherein said sample is normal cells or tissue.
Claim 7
Dependent Claim
13 words
Method as in claim 4, wherein said sample is cancerous cells or tissue.
Claim 8
Dependent Claim
14 words
Method as in claim 4, wherein said sample is melanin containing cells or tissue.
Claim 9
Dependent Claim
52 words
A method of diagnosing a melanoma which comprises contacting a sample from a subject with the monoclonal antibody of claim 3 under conditions so as to form a complex between the monoclonal antibody and an antigen derived from the melanoma and detecting the complex so formed, thereby diagnosing melanoma in the subject.
Claim 10
Dependent Claim
27 words
A method of claim 8 wherein the antigen is a pigmentation associated antigen weighing about 70-80 kilodaltons and having an isoelectric point of about 5.2 to 5.6.
References Cited (Backward Citations)
US4591572A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-17 | 1992-07-18 | 1993-01-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-17 | 1996-07-18 | 1997-01-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-17 | 2000-07-18 | 2001-01-17 | $7700.00 | Window Closed / Lapsed |