Patent US4795459A successfully refreshed from Google Patents.
US4795459A
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US
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Implantable prosthetic device with lectin linked endothelial cells
Assignee: Rhode Island Hospital
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Filing: 1987-05-18
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Granted: 1989-01-03
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Expires: 2007-05-18
Abstract
Abstract An implantable prosthetic device made of biocompatible polymer and having a substantially continuous layer of autologus living cells attached via oligosaccharidelectin recognition linkages.
Inventors
- 👤 Hugo O. Jauregui
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:58
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61L; A61L27/00; A61L27/36; A61L27/50; A61L27/507; C; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/089; C12N11/093; C12N11/096; Y; Y10; Y10S; Y10S436/00; Y10S436/827
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
46 words
An implantable prosthetic device comprising a member that has a shape to perform a cardiovascular prosthetic function when implanted, is made of biocompatible polymer, and has a surface to which a substantially continuous layer of autologous living endothelial cells has been attached via oligosaccharide-lectin recognition linkages.
Claim 2
Dependent Claim
46 words
An implantable prosthetic device comprising a member that has a shape to perform a cardiovascular prosthetic function when implanted, is made of biocompatible polymer, and has a surface to which a substantially continuous layer of autologous living endothelial cells has been attached via oligosaccharide-lectin recognition linkages.
Claim 3
Dependent Claim
27 words
The device of claim 2 wherein said lectin is covalently bound to said polymer, and said oligosaccharide is part of the cell surface of said living cells.
Claim 4
Dependent Claim
14 words
The device of claim 2 wherein said lectin is a lectin that recognizes α-L-fucose.
Claim 5
Dependent Claim
40 words
The device of claim 2 wherein said lectin is one of the group consisting of Ulex Europaeus agglutinin I, Lens culinaris agglutinin, Pisum sativum agglutinin, wheat germ agglutinin, Lotus tetragonolobus agglutinin, Ricinus communis agglutinin, Concanavalin A, and Cytisus sessilifolius agglutinin.
Claim 6
Dependent Claim
13 words
The device of claim 2 wherein said lectin is Ulex Europaeus agglutinin I.
Claim 7
Dependent Claim
12 words
The device of claim 2 wherein said lectin is wheat germ agglutinin.
Claim 8
Dependent Claim
22 words
The device of claim 1 wherein said member is a tubular vessel that is sufficiently small to function as a coronary artery.
Claim 9
Dependent Claim
10 words
The device of claim 1 wherein said polymer is PTFE.
Claim 10
Dependent Claim
10 words
The device of claim 1 wherein said polymer is polyurethane.
Claim 11
Dependent Claim
10 words
The device of claim 1 wherein said polymer is Dacron.
Claim 12
Dependent Claim
19 words
The device of claim 1 wherein said polymer is a bioresorbable polymer of a compound of the Krebs cycle.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-03 | 1992-07-04 | 1993-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-03 | 1996-07-04 | 1997-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-03 | 2000-07-04 | 2001-01-03 | $7700.00 | Window Closed / Lapsed |