Patent US4792449A successfully refreshed from Google Patents.
US4792449A
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US
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Method for drug administration
Assignee: Baxter International Inc
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Filing: 1987-01-28
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Granted: 1988-12-20
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Expires: 2007-01-28
Abstract
Abstract This invention relates to a method for administering drugs. In particular a lipophilic drug is solubilized by a food, such as chocolate, and admixed with an oil-based carrier. The lipid soluble drug is thus conveyed to the gastrointestinal tract. Because this type of food is digested readily, the drug is absorbed as intended, and the dose is not subject to day-to-day variations.
Inventors
- 👤 Robert K. Ausman
- 👤 Mark Adams
- 👤 Gerado Caballero
- 👤 Rahim Hamid
- 👤 Norman E. Hoffman
- 👤 Edward J. Quebbeman
- 👤 William J. Schulte
- 👤 Robert Thomson
- 👤 Julie Whipple
- 👤 Steven D. Weitman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:37
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
52 words
A method for providing a drug to a patient in a form suitable to be swallowed by the patient, where the drug is lipid soluble, but not water soluble, comprising the steps of: a. dissolving the drug in a lipid solution; and b. dissolving the resulting drug-lipid solution in liquid, candy-grade chocolate.
Claim 2
Independent Claim
52 words
A method for providing a drug to a patient in a form suitable to be swallowed by the patient, where the drug is lipid soluble, but not water soluble, comprising the steps of: a. dissolving the drug in a lipid solution; and b. dissolving the resulting drug-lipid solution in liquid, candy-grade chocolate.
Claim 3
Dependent Claim
48 words
The method according to claim 1 and further comprising the steps of: a. determining the volume of the drug-lipid solution; and b. removing a volume of coconut oil from the chocolate equal to the volume of the drug-lipid solution prior to dissolving the drug-lipid solution in the chocolate.
Claim 4
Independent Claim
52 words
A method for providing a drug to a patient in a form suitable to be swallowed by the patient, where the drug is lipid soluble, but not water soluble, comprising the steps of: a. dissolving the drug in olive oil; and b. dissolving the resulting drug-olive oil solution in liquid, candy-grade chocolate.
Claim 5
Independent Claim
52 words
A method for providing a drug to a patient in a form suitable to be swallowed by the patient, where the drug is lipid soluble, but not water soluble, comprising the steps of: a. dissolving the drug in olive oil; and b. dissolving the resulting drug-olive oil solution in liquid, candy-grade chocolate.
Claim 6
Dependent Claim
51 words
The method according to claim 3 and further comprising the steps of: a. determining the volume of the drug-olive oil solution; and b. removing a volume of coconut oil from the chocolate equal to the volume of the drug-olive oil solution prior to dissolving the drug-olive oil solution in the chocolate.
Claim 7
Independent Claim
42 words
A method for providing a cyclosporine drug to a patient in a form suitable to be swallowed by the patient, comprising the steps of: a. dissolving the cyclosporine drug in a lipid solution; and b. dissolving the resulting cyclosporine-lipid solution in chocolate.
Claim 8
Independent Claim
42 words
A method for providing a cyclosporine drug to a patient in a form suitable to be swallowed by the patient, comprising the steps of: a. dissolving the cyclosporine drug in a lipid solution; and b. dissolving the resulting cyclosporine-lipid solution in chocolate.
Claim 9
Dependent Claim
48 words
The method according to claim 5 and further comprising the steps of: a. determining the volume of the cyclosporine-lipid solution; and b. removing a volume of coconut oil from the chocolate equal to the volume of the cyclosporine-lipid solution prior to dissolving the cyclosporine-lipid solution in the chocolate.
Claim 10
Independent Claim
42 words
A method for providing a cyclosporine drug to a patient in a form suitable to be swallowed by the patient, comprising the steps of: a. dissolving the cyclosporine drug in olive oil; and b. dissolving the resulting cyclosporine-olive oil solution in chocolate.
Claim 11
Independent Claim
42 words
A method for providing a cyclosporine drug to a patient in a form suitable to be swallowed by the patient, comprising the steps of: a. dissolving the cyclosporine drug in olive oil; and b. dissolving the resulting cyclosporine-olive oil solution in chocolate.
Claim 12
Dependent Claim
48 words
The method according to claim 7 and further comprising the steps of: a. determining the volume of the cyclosporine-oil solution; and b. removing a volume of coconut oil from the chocolate equal to the volume of cyclosporine-olive oil solution prior to dissolving the cyclosporine-olive oil in the chocolate.
Claim 13
Dependent Claim
47 words
A drug dosage form of a candy-bar type consisting of cyclosporine dissolved in olive oil, said cyclosporine-olive-oil mixture being blended with a suitable vehicle including liquid, candy grade chocolate to produce a homogenous mixture in which the cyclosporine is distributed evenly throughout the chocolate in the bar.
Claim 14
Dependent Claim
47 words
A drug dosage form of a candy-bar type consisting of cyclosporine dissolved in olive oil, said cyclosporine-olive-oil mixture being blended with a suitable vehicle including liquid, candy grade chocolate to produce a homogenous mixture in which the cyclosporine is distributed evenly throughout the chocolate in the bar.
Claim 15
Dependent Claim
18 words
The drug dosage form of claim 9 including from about 25 milligrams to about 500 milligrams of cyclosporine.
Claim 16
Dependent Claim
35 words
The drug dosage form of claim 10 wherein the vehicle includes sugar, cocoa butter, whole milk powder, chocolate liquor, lecithin and vanillin, each in the range of from about 10% to 20% of the total.
References Cited (Backward Citations)
US4609543A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-20 | 1992-06-20 | 1992-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-20 | 1996-06-20 | 1996-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-20 | 2000-06-20 | 2000-12-20 | $7700.00 | Window Closed / Lapsed |