Production of antibody catalysts

Claim 1

Process for producing an antibody catalyst for a chemical reaction, which comprises: (1) identifying a substrate represented by formula R.sub.1 --X--R.sub.2 for said reaction; (2) selecting a hapten represented by formula ##STR26## wherein X represents nuclei O, S, N, and C and associated bonds which comprise the catalytically active portion of the substrate molecule and Y represents nuclei N, C, and P and associated bonds which comprise the catalytically active portion of the hapten molecule and X and Y are related to each other in that Y has a higher valence state and one or more bonds than X, and wherein Q is selected from the group of substituents consisting of (a) a positive charge, (b) a negative charge, (c) polarity, (d) non-polarity, and (e) substantial bulk bonded to Y wherein R 1 , R 2 , R 1 ' and R 2 ' represent the residual chemical groups of the substrate and hapten which do not participate in the catalytic events, and R 1 and R 1 ', and R 2 and R 2 ' are, respectively substantially similar to each other which corresponds to said substrate; (3) stimulating an immune response by said hapten; and (4) isolating antibodies from said immune response which are catalytically active for said chemical reaction.