US4790989A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of fungal infections
Assignee: Beecham Group PLC
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Filing: 1987-04-10
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Granted: 1988-12-13
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Expires: 2007-04-10
Abstract
Abstract Certain formulations of pseudomonic acids and their salts have good antifungal activity.
Inventors
- 👤 Pamela A. Hunter
- 👤 Valerie Berry
- 👤 Joshua Oduro-Yeboah
- 👤 Norman A. Orr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:04
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
80 words
A method for the treatment of a fungal infection, which comprises applying topically to a patient an antifungally effective amount of a topical pharmaceutical or veterinary composition comprising a pseudomonic acid or a non-toxic pharmaceutically or veterinary acceptable salt thereof, and a pharmaceutically or veterinary acceptable carrier, the pseudomonic acid or salt thereof being present in an amount that, in use, corresponds to at least the saturation solubility of the pseudomonic acid or salt in the carrier at ambient temperature.
Claim 2
Independent Claim
80 words
A method for the treatment of a fungal infection, which comprises applying topically to a patient an antifungally effective amount of a topical pharmaceutical or veterinary composition comprising a pseudomonic acid or a non-toxic pharmaceutically or veterinary acceptable salt thereof, and a pharmaceutically or veterinary acceptable carrier, the pseudomonic acid or salt thereof being present in an amount that, in use, corresponds to at least the saturation solubility of the pseudomonic acid or salt in the carrier at ambient temperature.
Claim 3
Dependent Claim
41 words
A method as claimed in claim 1, wherein the pseudomonic acid or salt thereof is present in the composition in an amount that, in use, exceeds the saturation solubility of the pseudomonic acid or salt in the carrier at ambient temperature.
Claim 4
Dependent Claim
22 words
A method as claimed in claim 2, wherein the said amount is at least 150% by weight of the said saturation solubility.
Claim 5
Dependent Claim
17 words
A method as claimed in claim 1, wherein the salt of pseudomonic acid is crystalline calcium mupirocin.
Claim 6
Dependent Claim
37 words
A method as claimed in claim 1, wherein the pseudomonic acid or salt thereof is present in the composition in an amount of from 0.5 to 10% by weight, based on the total weight of the composition.
Claim 7
Dependent Claim
37 words
A method as claimed in claim 5, wherein the pseudomonic acid or salt thereof is present in the composition in an amount of from 1 to 3% by weight, based on the total weight of the composition.
Claim 8
Dependent Claim
50 words
A method as claimed in claim 1, wherein the composition comprises from 1 to 3% of mupirocin or a salt thereof, from 65 to 96% of white soft paraffin, from 0 to 15% of liquid paraffin, and from 3 to 7% of lanolin or a derivative or synthetic equivalent thereof.
Claim 9
Dependent Claim
41 words
A method as claimed in claim 1, wherein the composition comprises from 1 to 3% of mupirocin or a salt thereof, from 25 to 60% of liquid paraffin, from 20 to 50% of water, and from 3 to 30% of emulsifier.
Claim 10
Dependent Claim
17 words
A method as claimed in claim 1, for the treatment of fungal infections caused by filamentous fungi.
Claim 11
Dependent Claim
25 words
A method as claimed in claim 1, for the treatment of fungal infections caused by species of Aspergillus, Trichophyton, Trichosporon, Hendersonula, Microsporum, Epidermophyton, and Pityrosporum.
References Cited (Backward Citations)
JPS54123A
Cited
US4524075A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-13 | 1992-06-13 | 1992-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-13 | 1996-06-13 | 1996-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-13 | 2000-06-13 | 2000-12-13 | $7700.00 | Window Closed / Lapsed |