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US4790305A Expired / Lapsed US ⏱️ 0.0 years remaining

Medication delivery system

Assignee: Johns Hopkins University
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Filing: 1986-06-23
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Granted: 1988-12-13
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Expires: 2006-06-23
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Abstract

Abstract Apparatus for use in inhaling pharmaceutical aerosols. The apparatus comprises a mouthpiece for supplying a pharmaceutical composition to the mouth of a patient, a rigid chamber for holding the aerosol prior to inhalation, the rigid chamber having orifices to limit the flow of air therethrough, and a collapsable chamber from which the patient inhales unmedicated air prior to inhaling the medicated air from the rigid chamber. The apparatus increases medication delivered to the small peripheral bronchi, while it limits deposition in the oropharynx. The patient is aided in inhaling a volume of unmedicated air, after which he automatically begins to receive the aerosolized medication with the inhaled air. The volumetric flow rate of the inhaled medication is kept below required limits for optimal dosing.

Inventors

  • 👤 Bart J. Zoltan
  • 👤 Beth L. Laube
  • 👤 George K. Adams, III

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-27 20:45
CPC Classifications
A; A61; A61M; A61M15/00; A61M15/0086; A61M15/0088; A61M15/009

Claims Analysis

Total Claims: 13
Claim 1
Independent Claim 78 words
A device for delivery of aerosolized medication to a patient, said device comprising: a mouthpiece having an inhalation end and another end; means for connecting a medication container to said mouthpiece intermediate said ends; first chamber means fixed to said mouthpiece at said other end for holding the aerosolized medication before inhalation thereof; and further chamber means fixed to said mouthpiece for supplying a variable volume of air to said inhalation end before the aerosolized medication is inhaled.
Claim 2
Independent Claim 78 words
A device for delivery of aerosolized medication to a patient, said device comprising: a mouthpiece having an inhalation end and another end; means for connecting a medication container to said mouthpiece intermediate said ends; first chamber means fixed to said mouthpiece at said other end for holding the aerosolized medication before inhalation thereof; and further chamber means fixed to said mouthpiece for supplying a variable volume of air to said inhalation end before the aerosolized medication is inhaled.
Claim 3
Dependent Claim 22 words
The device of claim 1 including means for varying the resistance of said first chamber means to the flow of air therethrough.
Claim 4
Dependent Claim 33 words
The device of claim 2 wherein said first chamber means includes one or more orifices as the means for varying the resistance of said first chamber means to the flow of air therethrough.
Claim 5
Independent Claim 244 words
An apparatus for delivering aerosolized medication to a patient, of the type including a medication container and metering means, said apparatus comprising: a first rigid chamber; a second collapsible chamber; a mouthpiece, said mouthpiece having a first end and a second end, said mouthpiece having a first passageway extending lengthwise therethrough from said first end to said second end, said first end being shaped to accommodate the human mouth for inhalation purposes, said mouthpiece further having a second passageway transverse to said first passageway, said second passageway being positioned between said first end and said second end and being in open communication with said first passageway, said mouthpiece further including means for connecting to the medication container, and passage means for directing medication from the container out the second end of said mouthpiece for discharge into said first rigid chamber; said first rigid chamber having first and second end walls, said first end wall having an opening which is pneumatically connected to said first passageway of said mouthpiece at the second end thereof, the second end wall of said first rigid chamber having means for limiting the volumetric flow of air therethrough; and said second collapsible chamber being pneumatically connected to said second passageway in said mouthpiece; thereby allowing the patient to meter medication into said first rigid chamber, and to inhale through said mouthpiece, automatically inhaling the non-medicated contents of said second collapsible chamber before inhaling the medication from the rigid first chamber.
Claim 6
Independent Claim 244 words
An apparatus for delivering aerosolized medication to a patient, of the type including a medication container and metering means, said apparatus comprising: a first rigid chamber; a second collapsible chamber; a mouthpiece, said mouthpiece having a first end and a second end, said mouthpiece having a first passageway extending lengthwise therethrough from said first end to said second end, said first end being shaped to accommodate the human mouth for inhalation purposes, said mouthpiece further having a second passageway transverse to said first passageway, said second passageway being positioned between said first end and said second end and being in open communication with said first passageway, said mouthpiece further including means for connecting to the medication container, and passage means for directing medication from the container out the second end of said mouthpiece for discharge into said first rigid chamber; said first rigid chamber having first and second end walls, said first end wall having an opening which is pneumatically connected to said first passageway of said mouthpiece at the second end thereof, the second end wall of said first rigid chamber having means for limiting the volumetric flow of air therethrough; and said second collapsible chamber being pneumatically connected to said second passageway in said mouthpiece; thereby allowing the patient to meter medication into said first rigid chamber, and to inhale through said mouthpiece, automatically inhaling the non-medicated contents of said second collapsible chamber before inhaling the medication from the rigid first chamber.
Claim 7
Dependent Claim 13 words
Apparatus according to claim 4, wherein the medication container comprises a pressurized aerosol.
Claim 8
Dependent Claim 13 words
Apparatus according to claim 4, wherein the medication container comprises a spray dispenser.
Claim 9
Dependent Claim 35 words
Apparatus according to claim 4, wherein said limiting means comprises means defining one or more orifices for limiting the volumetric flow of air through said first rigid chamber to 30 liters per minute or less.
Claim 10
Dependent Claim 24 words
Apparatus according to claim 4, wherein said second collapsible chamber has flexible walls, whereby the volume of gas held in said chamber is adjustable.
Claim 11
Dependent Claim 20 words
Apparatus according to claim 8, further comprising indicia on the outside of said collapsible chamber to indicate said adjustable volume.
Claim 12
Independent Claim 266 words
A device for aiding a patient in inhaling medication, of the type having a pressurized aerosol medication container and having a metering means, said device comprising: a first rigid chamber; a second collapsible chamber, said second collapsible chamber including means for adjusting the volume of air contained therein and indicia means to indicate said adjustable volume; a mouthpiece, said mouthpiece having a near and far end, said mouthpiece having a first opening therethrough, said first opening connecting said near end to said far end, said near end being shaped to accommodate the human mouth, said mouthpiece further having a second opening between said near end and said far end, said second opening meeting said first opening, and said mouthpiece further including means for connecting said mouthpiece to the medication container, and means for directing the medication out the far end of said mouthpiece into said first rigid chamber; said first rigid chamber having a first and second end, said first end having an opening pneumatically connected to said far end of said mouthpiece; said first rigid chamber further including one or more small orifices in its second end for the purpose of limiting the volumetric flow of air therethrough so that the volumetric flow rate is at or below 30 liters per minute; and said second collapsible chamber being pneumatically connected to said second opening in said mouthpiece; thereby allowing the patient to first meter medication into said first rigid chamber, and to inhale through said mouthpiece, while automatically inhaling the non-medicated contents of said second collapsible chamber for inhaling medication through the rigid first chamber.
Claim 13
Independent Claim 266 words
A device for aiding a patient in inhaling medication, of the type having a pressurized aerosol medication container and having a metering means, said device comprising: a first rigid chamber; a second collapsible chamber, said second collapsible chamber including means for adjusting the volume of air contained therein and indicia means to indicate said adjustable volume; a mouthpiece, said mouthpiece having a near and far end, said mouthpiece having a first opening therethrough, said first opening connecting said near end to said far end, said near end being shaped to accommodate the human mouth, said mouthpiece further having a second opening between said near end and said far end, said second opening meeting said first opening, and said mouthpiece further including means for connecting said mouthpiece to the medication container, and means for directing the medication out the far end of said mouthpiece into said first rigid chamber; said first rigid chamber having a first and second end, said first end having an opening pneumatically connected to said far end of said mouthpiece; said first rigid chamber further including one or more small orifices in its second end for the purpose of limiting the volumetric flow of air therethrough so that the volumetric flow rate is at or below 30 liters per minute; and said second collapsible chamber being pneumatically connected to said second opening in said mouthpiece; thereby allowing the patient to first meter medication into said first rigid chamber, and to inhale through said mouthpiece, while automatically inhaling the non-medicated contents of said second collapsible chamber for inhaling medication through the rigid first chamber.

References Cited (Backward Citations)

FR773018A Cited
US3923043A Cited
US4484577A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1991-12-13 1992-06-13 1992-12-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1995-12-13 1996-06-13 1996-12-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1999-12-13 2000-06-13 2000-12-13 $7700.00 Window Closed / Lapsed

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