Drug delivery method and inhalation device therefor

Claim 3

A method of claim 1, wherein said signal is a whistle housed in said means for communicating with a breathing passage which is activated by air passing through said whistle at a rate in excess of the desired rate for delivery of said drug.

Claim 4

A method of claim 1, wherein the breathing passage is the mouth.

Claim 5

A method of claim 3, wherein the drug is delivered for absorption on the tracheobronchial tree.

Claim 6

A method of claim 4 for the delivery of a pulmonary medicine.

Claim 7

A method of claim 5, wherein said pulmonary medicine is a bronchodilator.

Claim 8

A method of claim 6, wherein said bronchodilator is 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-benzene diol.

Claim 9

A method of claim 6, wherein said bronchodilator is 4-hydroxy-3-hydroxymethyl-alpha-[(tert-butylamino)methyl]benzyl alcohol.

Claim 10

A method of claim 1, wherein the breathing passage is the nose.

Claim 11

A method of claim 9, wherein the amount of drug which enters the system of the patient other than through the nasal mucous membranes is minimized by said patient and maximum contact with the nasal mucous tissue is enhanced, further comprising the step, after said collapsing said expanded bag, of maintaining said means for communicating with a breathing passage in contact with the nose and then reexpanding said expanded bag, whereby the drug passes over the mucous tissues of the nasal passage a second time and the amount of drug which goes beyond the nasal passage for communication with the tracheobronchial or gastrointestinal routes is minimized.

Claim 12

A method of claim 9 or 10, wherein said drug is a nasal decongestant.

Claim 13

A method of claim 9 or 10, wherein said drug is 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-benzene diol.

Claim 14

A method of claim 9 or 10, wherein said drug is 4-hydroxy-3-hydroxymethyl-alpha-[(tert-butylamino)methyl]benzyl alcohol.

Claim 15

A method of claim 9 or 10, wherein said drug is a systemically active drug.

Claim 16

A drug delivery device for administering a drug contained in an aerosol to a breathing passage of a patient for absorption on the mucous tissue of the patient which comprises (a) a collapsible airbag of fixed maximum dimensions which is impervious to passage of air except for an airbag opening; (b) a piece having one end adapted for communication with the breathing passage and connected by a bidirectional channel through said piece to the opposite end thereof to said airbag opening, said piece having a drug introduction opening for the introduction of an aerosol spray containing a predetermined amount of a drug, said drug introduction opening disposed such that said aerosol spray is introduced directly into said airbag through said piece and said airbag opening, in a direction away from said one end; and (c) signal means in said bidirectional channel to indicate when the rate of inhalation of said aerosol spray from said airbag exceeds a desirable limit, whereby the patient taking said drug is reminded to decrease the rate of collapse of said airbag, thereby maximizing drug utilization; said drug delivery device admitting a drug-containing aerosol through said drug introduction opening while said collapsible airbag is at least partially expanded, said drug being introduced into said the breathing passage with the contraction of said collapsible airbag through inhalation by said patient.

Claim 17

A drug delivery device for administering a drug contained in an aerosol to a breathing passage of a patient for absorption on the mucous tissue of the patient which comprises (a) a collapsible airbag of fixed maximum dimensions which is impervious to passage of air except for an airbag opening; (b) a piece having one end adapted for communication with the breathing passage and connected by a bidirectional channel through said piece to the opposite end thereof to said airbag opening, said piece having a drug introduction opening for the introduction of an aerosol spray containing a predetermined amount of a drug, said drug introduction opening disposed such that said aerosol spray is introduced directly into said airbag through said piece and said airbag opening, in a direction away from said one end; and (c) signal means in said bidirectional channel to indicate when the rate of inhalation of said aerosol spray from said airbag exceeds a desirable limit, whereby the patient taking said drug is reminded to decrease the rate of collapse of said airbag, thereby maximizing drug utilization; said drug delivery device admitting a drug-containing aerosol through said drug introduction opening while said collapsible airbag is at least partially expanded, said drug being introduced into said the breathing passage with the contraction of said collapsible airbag through inhalation by said patient.

Claim 18

A drug delivery device of claim 15, wherein said signal means is a whistle activated by passage of air from said airbag into said bidirectional channel at a rate in excess of the desirable limit for effective drug utilization.

Claim 19

A drug delivery device of claim 16, wherein said whistle is a reed.

Claim 20

A drug delivery device of claim 16, wherein said piece is a mask adapted for communication with the nose, whereby said drug is delivered to the nasal mucous membranes.

Claim 21

A drug delivery device of claim 15, wherein said piece is a tube adapted for communication with the mouth, whereby said drug is delivered to the tracheobronchial tree.

Claim 22

A drug delivery device of claim 19, wherein said collapsible bag has a first apertured end cap having said airbag opening and a second end cap facing said first apertured end cap, said two end caps being connected by a collapsible material.

Claim 23

A drug delivery device of claim 20, wherein said collapsible material is attached to said two end caps and is adapted such that as said airbag collapses, the facing end caps rotate in relation to each other.

Claim 24

A drug delivery device of claim 16, 17, 19, 20 or 21, wherein said drug is a bronchodilator.

Claim 25

A drug delivery device of claim 16, 17, 19, 20 or 21, wherein said drug is 5-[1-hydroxy-2-[(1-methylethyl)amino]-ethyl]-benzene diol.

Claim 26

A drug delivery of claim 16, 17, 19, 20 or 21, wherein said drug is 4-hydroxy-3-hydroxymethyl-alpha-[(tert-butylamino)methyl]benzyl alcohol.