Patent US4789732A successfully refreshed from Google Patents.
US4789732A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone morphogenetic protein composition
Assignee: University of California, San Diego
•
Filing: 1988-03-09
•
Granted: 1988-12-06
•
Expires: 2008-03-09
Abstract
Abstract BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals.
Inventors
- 👤 Marshall R. Urist
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:23
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
91 words
The process of inducing bone formation in animals comprising the steps of implanting into said animals substantially pure BMP compositions comprising BMP factor and at least one BMP associated protein selected from a group consisting of BMP associated proteins having molecular weights in the range of between about 24 kDa and about 34 kDa, said BMP factor being capable of inducing bone formation independent of the presence of said BMP associated proteins, and said BMP associated proteins being incapable of inducing bone formation independent of the presence of said BMP factor.
Claim 2
Dependent Claim
91 words
The process of inducing bone formation in animals comprising the steps of implanting into said animals substantially pure BMP compositions comprising BMP factor and at least one BMP associated protein selected from a group consisting of BMP associated proteins having molecular weights in the range of between about 24 kDa and about 34 kDa, said BMP factor being capable of inducing bone formation independent of the presence of said BMP associated proteins, and said BMP associated proteins being incapable of inducing bone formation independent of the presence of said BMP factor.
Claim 3
Dependent Claim
17 words
The process of claim 1 wherein said BMP composition activates DNA sequences that code for bone morphogenesis.
Claim 4
Dependent Claim
31 words
The process of claim 1 wherein said BMP composition consists essentially of about 7 parts 22-kDa and about 1 part 14-kDa BMP associated proteins, and about 2 parts 18.5±0.5-kDa bBMP factor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-06 | 1992-06-06 | 1992-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-06 | 1996-06-06 | 1996-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-06 | 2000-06-06 | 2000-12-06 | $7700.00 | Window Closed / Lapsed |