US4788196A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenyl piperazine anti-arrhythmia agents
Assignee: Pfizer Inc
•
Filing: 1987-04-17
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Granted: 1988-11-29
•
Expires: 2007-04-17
Abstract
Abstract A series of pyridyl or imidazolyl substituted phenyl piperazines having utility as anti-arrhythmic agents is disclosed.
Inventors
- 👤 Peter E. Cross
- 👤 Roger P. Dickinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 09:08
CPC Classifications
C; C07; C07D; C07D241/00; C07D241/02; C07D241/04; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/74; A; A61; A61P; A61P9/00; A61P9/06; C07D233/00; C07D233/54; C07D233/66; C07D233/88
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
111 words
A compound of the formula: ##STR11## or a pharmaceutically acceptable salt thereof, wherein R is R 3 SO 2 NH--, R 3 CONH--. R 1 R 2 NSO 2 --, or R 1 R 2 NCO--; R 1 and R 2 are each independently H or C 1 -C 4 alkyl; R 3 is C 1 -C 4 alkyl, C 3 -C 7 cycloalkyl or NR 1 R 2 ; and "Het" is 2, 3 or 4-pyridyl optionally substituted by one or more substituents each independently selected from C 1 -C 4 alkyl and NH 2 ; or 2-imidazolyl optionally substituted by one or more C 1 -C 4 alkyl groups.
Claim 2
Dependent Claim
111 words
A compound of the formula: ##STR11## or a pharmaceutically acceptable salt thereof, wherein R is R 3 SO 2 NH--, R 3 CONH--. R 1 R 2 NSO 2 --, or R 1 R 2 NCO--; R 1 and R 2 are each independently H or C 1 -C 4 alkyl; R 3 is C 1 -C 4 alkyl, C 3 -C 7 cycloalkyl or NR 1 R 2 ; and "Het" is 2, 3 or 4-pyridyl optionally substituted by one or more substituents each independently selected from C 1 -C 4 alkyl and NH 2 ; or 2-imidazolyl optionally substituted by one or more C 1 -C 4 alkyl groups.
Claim 3
Dependent Claim
14 words
A compound according to claim 1 wherein R is CH 3 SO 2 NH.
Claim 4
Dependent Claim
21 words
A compound according to claim 1 wherein Het is 2 or 4-pyridyl optionally substituted by CH 3 or NH 2 .
Claim 5
Dependent Claim
21 words
A compound according to claim 2 wherein Het is 2 or 4-pyridyl optionally substituted by CH 3 or NH 2 .
Claim 6
Dependent Claim
18 words
A compound according to claim 1 wherein R is CH 3 SO 2 NH and Het is 4-pyridyl.
Claim 7
Dependent Claim
18 words
A compound according to claim 1 wherein R is CH 3 SO 2 NH-- and Het is 2-methyl-4-pyridyl.
Claim 8
Dependent Claim
18 words
A compound according to claim 1 wherein R is CH 3 SO 2 NH and Het is 4-amino-2-pyridyl.
Claim 9
Dependent Claim
24 words
A pharmaceutical composition comprising a compound of claim 1 in an amount effective to treat cardiac arrhythmias and a pharmaceutically acceptable diluent or carrier.
Claim 10
Dependent Claim
36 words
A method of treating cardiac arrhythmias comprising administering to a arrhythmic host in need of such treatment an anti-arrhythmic effective dose of a compound of claim 1 in combination with a pharmaceutically acceptable diluent or carrier.
Claim 11
Dependent Claim
49 words
A compound of the formula: ##STR12## wherein R is as defined in claim 1 and Het' is 2, 3, or 4-pyridyl or an N-oxide thereof substituted by NO 2 or wherein Het' is 2, 3 or 4-pyridyl substituted by --CONHNH 2 or --NHCO 2 (C 1 -C 4 alkyl).
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-29 | 1992-05-30 | 1992-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-29 | 1996-05-30 | 1996-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-29 | 2000-05-30 | 2000-11-29 | $7700.00 | Window Closed / Lapsed |