Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles

Claim 2

A chemical compound selected from the group consisting of an azole derivative having the formula: ##STR36## and the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein: Q is a member selected from the group consisting of CH and N; Ar is a member selected from the group consisting of phenyl, thienyl, halothienyl and substituted phenyl, said substituted phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, lower alkyl, lower alkyloxy and trifluoromethyl; and the radical Y is an optionally substituted mono- or binuclear nitrogen-containing heteroaromatic radical selected from the group consisting of: a radical of formula ##STR37## wherein R 1 is selected from the group consisting of hydrogen, lower alkylthio, aryl lower alkylthio and arylthio and R 2 and R 3 are each independently selected from the group consisting of hydrogen, lower alkyl, aryl and aryl lower alkyl; a radical of formula ##STR38## wherein each of R 4 and R 5 are independently selected from the group consisting of hydrogen, lower alkyl, aryl and aryllower alkyl; a radical of formula ##STR39## wherein L is a member selected from the group consisting of S and N-R 18 , said R 18 being selected from the group consisting of hydrogen, lower alkyl and aryllower alkyl, and R 16 and R 17 are each independently selected from the group consisting of hydrogen, lower alkyl, nitro and aryllower alkyl, or R 16 and R 17 , when taken together, represent a radical of the formula --CH═CH--CH═CH--.

Claim 3

A chemical compound selected from the group consisting of cis-8-[4-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol--ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-1-piperazinyl]-7-ethyl-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione and the pharmaceutically acceptable acid addition salts thereof.

Claim 4

A chemical compound selected from the group consisting of cis-8-[4-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol--ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-1-piperazinyl]-7-ethyl-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione and the pharmaceutically acceptable acid addition salts thereof.

Claim 5

A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-4-(2-thiazolyl)piperazine and the pharmaceutically acceptable acid addition salts thereof.

Claim 6

A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-4-(2-thiazolyl)piperazine and the pharmaceutically acceptable acid addition salts thereof.

Claim 7

A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]-phenyl}-4-(1H-imidazol-1-yl)piperazine hemihydrate and the pharmaceutically acceptable acid addition salts thereof.

Claim 8

A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]-phenyl}-4-(1H-imidazol-1-yl)piperazine hemihydrate and the pharmaceutically acceptable acid addition salts thereof.

Claim 9

A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective antifungal or antibacterial amount of a compound selected from the group consisting of an azole derivative having the formula: ##STR40## and the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein: Q is a member selected from the group consisting of CH and N; Ar is a member selected from the group consisting of phenyl, thienyl, halothienyl and substituted phenyl, said substituted phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, lower alkyl, lower alkyloxy and trifluoromethyl; and the radical Y is an optionally substituted mono- or binuclear nitrogen-containing heteroaromatic radical selected from the group consisting of: a radical of formula ##STR41## wherein R 1 is selected from the group consisting of hydrogen, lower alkylthio, aryllower alkylthio and arylthio and R 2 and R 3 are each independently selected from the group consisting of hydrogen, lower alkyl, aryl and aryllower alkyl; a radical of formula ##STR42## wherein each of R 4 and R 5 are independently selected from the group consisting of hydrogen, lower alkyl, aryl and aryllower alkyl; a radical of formula ##STR43## wherein L is a member selected from the group consisting of S and N-R 18 , said R 18 being selected from the group consisting of hydrogen, lower alkyl and aryllower alkyl, and R 16 and R 17 are each independently selected from the group consisting of hydrogen, lower alkyl, nitro and aryllower alkyl, or R 16 and R 17 , when taken together, represent a radical of the formula --CH═CH--CH═CH--.

Claim 10

A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective antifungal or antibacterial amount of a compound selected from the group consisting of an azole derivative having the formula: ##STR40## and the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein: Q is a member selected from the group consisting of CH and N; Ar is a member selected from the group consisting of phenyl, thienyl, halothienyl and substituted phenyl, said substituted phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, lower alkyl, lower alkyloxy and trifluoromethyl; and the radical Y is an optionally substituted mono- or binuclear nitrogen-containing heteroaromatic radical selected from the group consisting of: a radical of formula ##STR41## wherein R 1 is selected from the group consisting of hydrogen, lower alkylthio, aryllower alkylthio and arylthio and R 2 and R 3 are each independently selected from the group consisting of hydrogen, lower alkyl, aryl and aryllower alkyl; a radical of formula ##STR42## wherein each of R 4 and R 5 are independently selected from the group consisting of hydrogen, lower alkyl, aryl and aryllower alkyl; a radical of formula ##STR43## wherein L is a member selected from the group consisting of S and N-R 18 , said R 18 being selected from the group consisting of hydrogen, lower alkyl and aryllower alkyl, and R 16 and R 17 are each independently selected from the group consisting of hydrogen, lower alkyl, nitro and aryllower alkyl, or R 16 and R 17 , when taken together, represent a radical of the formula --CH═CH--CH═CH--.