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Patent US4788181A successfully refreshed from Google Patents.
US4788181A
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5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
Assignee: United States Department of Health and Human Services
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Filing: 1986-09-29
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Granted: 1988-11-29
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Expires: 2006-09-29
Abstract
Abstract 5-substituted 2',3'-dideoxycytidine compounds and their monophosphates are disclosed which have been found to have potent activity against retroviruses. The 5-fluoro-and 5-aza-substituted 2',3'-dideoycytidine compounds have been found to be effective against HTLV-III/LAV virus.
Inventors
- 👤 John S. Driscoll
- 👤 Victor E. Marquez
- 👤 Chong-Ho Kim
- 👤 James A. Kelley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 02:06
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
20 words
A 5-substituted 2',3'-dideoxycytidine compound of the formula: ##STR5## wherein X is selected from the group consisting of bromine and fluorine.
Claim 2
Dependent Claim
20 words
A 5-substituted 2',3'-dideoxycytidine compound of the formula: ##STR5## wherein X is selected from the group consisting of bromine and fluorine.
Claim 3
Dependent Claim
10 words
The compound according to claim 1 wherein X is fluorine.
Claim 4
Dependent Claim
10 words
The compound according to claim 1 wherein X is bromine.
Claim 5
Dependent Claim
19 words
A phosphorylated compound of the formula ##STR6## wherein X is selected from the group consisting of bromine and fluorine.
Claim 6
Dependent Claim
19 words
A phosphorylated compound of the formula ##STR6## wherein X is selected from the group consisting of bromine and fluorine.
Claim 7
Dependent Claim
9 words
The compound of claim 4 wherein X is bromine.
Claim 8
Dependent Claim
10 words
The compound according to claim 4 wherein X is fluorine.
Claim 9
Dependent Claim
23 words
A method for protecting cells against HIV pathogenesis comprising treating said cells with an effective amount of a compound according to claim 1.
Claim 10
Dependent Claim
23 words
A method for protecting cells against HIV pathogenesis comprising treating said cells with an effective amount of a compound according to claim 4.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-29 | 1992-05-30 | 1992-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-29 | 1996-05-30 | 1996-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-29 | 2000-05-30 | 2000-11-29 | $7700.00 | Window Closed / Lapsed |