US4783523A
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Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides
Assignee: UAB RESEARCH FOUNDATION NON-PROFIT CORP
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Filing: 1986-08-27
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Granted: 1988-11-08
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Expires: 2006-08-27
Abstract
Abstract A bioelastomer containing elastomeric units comprising tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 is PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 together constitute at least one of said pentameric unit, in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Inventors
- 👤 Dan W. Urry
- 👤 K. U. M. Prasad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:33
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/50; A61L27/507; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/29; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2929
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
171 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 is PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 2
Dependent Claim
171 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 is PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 3
Independent Claim
182 words
A method of decreasing the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 is PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 4
Independent Claim
182 words
A method of decreasing the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 is PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 5
Dependent Claim
194 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises: (A) a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- and (B) a polypentapeptide unit of the formula: --X.sup.2 --(VPGVG).sub.n --Y.sup.2 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 and X 2 are each PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 or X 2 and Y 2 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 6
Dependent Claim
194 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises: (A) a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- and (B) a polypentapeptide unit of the formula: --X.sup.2 --(VPGVG).sub.n --Y.sup.2 -- wherein I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 and X 2 are each PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 or X 2 and Y 2 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 7
Independent Claim
211 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- or a polypentapeptide unit of the formula: --X.sup.2 --(VPGVG).sub.n --Y.sup.2 -- or a mixture thereof, wherein for the above formulas, I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 and X 2 are each PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 or X 2 and Y 2 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 8
Independent Claim
211 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.1 --(IPGVG).sub.n --Y.sup.1 -- or a polypentapeptide unit of the formula: --X.sup.2 --(VPGVG).sub.n --Y.sup.2 -- or a mixture thereof, wherein for the above formulas, I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; and wherein X 1 and X 2 are each PGVG, GVG, VG, G or a covalent bond; Y 1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X 1 and Y 1 or X 2 and Y 2 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 9
Dependent Claim
161 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a tetrapeptide unit of the formula: --X.sup.3 --(IPGVG).sub.n --Y.sup.3 -- wherein X 3 is PGG, GG, G or a covalent bond; Y 3 is VPG, VP, V OR a covalent bond; and V is a peptide-producing residue of L-valine; P is a peptide-producing residue of L-proline; and G is a peptide-producing residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 3 and Y 3 together constitute at least one of said tetrameric unit, in an amount sufficient to increase the temperature at which the elastomeric force of the bioelastomer develops.
Claim 10
Dependent Claim
161 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a tetrapeptide unit of the formula: --X.sup.3 --(IPGVG).sub.n --Y.sup.3 -- wherein X 3 is PGG, GG, G or a covalent bond; Y 3 is VPG, VP, V OR a covalent bond; and V is a peptide-producing residue of L-valine; P is a peptide-producing residue of L-proline; and G is a peptide-producing residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 3 and Y 3 together constitute at least one of said tetrameric unit, in an amount sufficient to increase the temperature at which the elastomeric force of the bioelastomer develops.
Claim 11
Dependent Claim
166 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptiude or units thereof modified by hexapeptide repeating units and mixutres thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises incorporating into said bioelastomer a tetrapeptide unit of the formula: --X.sup.3 --(IPGVG).sub.n --Y.sup.3 -- wherein X 3 is PGG, GG, G or a covalent bond; Y 3 is VPG, VP, V OR a covalent bond; and V is a peptide-producing residue of L-valine; P is a peptide-producing residue of L-proline; and G is a peptide-producing residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 3 and Y 3 together constitute at least one of said tetrameric unit, in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 12
Dependent Claim
166 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptiude or units thereof modified by hexapeptide repeating units and mixutres thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises incorporating into said bioelastomer a tetrapeptide unit of the formula: --X.sup.3 --(IPGVG).sub.n --Y.sup.3 -- wherein X 3 is PGG, GG, G or a covalent bond; Y 3 is VPG, VP, V OR a covalent bond; and V is a peptide-producing residue of L-valine; P is a peptide-producing residue of L-proline; and G is a peptide-producing residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 3 and Y 3 together constitute at least one of said tetrameric unit, in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 13
Dependent Claim
161 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.4 --(IPGG).sub.n --Y.sup.4 -- wherein X 4 is PGG, GG G or a covalent bond; Y 4 is IPG, IP, I or a covalent bond; and I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 4 and Y 4 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 14
Dependent Claim
161 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.4 --(IPGG).sub.n --Y.sup.4 -- wherein X 4 is PGG, GG G or a covalent bond; Y 4 is IPG, IP, I or a covalent bond; and I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 4 and Y 4 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 15
Independent Claim
172 words
A method of adjusting the temperature of elastomer force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.4 --(IPGVG).sub.n --Y.sup.4 -- wherein X 4 is PGG, GG, G or a covalent bond; Y 4 is IPG, IP, I or a covalent bond; and I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 4 and Y 4 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 16
Independent Claim
172 words
A method of adjusting the temperature of elastomer force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --X.sup.4 --(IPGVG).sub.n --Y.sup.4 -- wherein X 4 is PGG, GG, G or a covalent bond; Y 4 is IPG, IP, I or a covalent bond; and I is a peptide-forming residue of L-isoleucine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; and n is an integer from 1 to 200, or n is 0, with the proviso that X 4 and Y 4 together constitute at least one of said pentameric unit in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.
Claim 17
Dependent Claim
115 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a tetra peptide or a polypentapeptide unit or mixture thereof or repeating units thereof, capable of adjusting the temperature at which elastomeric force of the bioelastomer develops, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature, with the proviso that the elasticity of the bioelastomer is retained.
Claim 18
Dependent Claim
115 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a tetra peptide or a polypentapeptide unit or mixture thereof or repeating units thereof, capable of adjusting the temperature at which elastomeric force of the bioelastomer develops, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature, with the proviso that the elasticity of the bioelastomer is retained.
Claim 19
Dependent Claim
31 words
A bioelastomer according to claim 9, which further comprises a fibroblastic chemotactic hexapeptide or a nonapeptide unit or repeating units an amount sufficient to impart fibroblastic chemotactic properties to said bioelastomer.
Claim 20
Dependent Claim
22 words
The bioelastomer according to claim 10, wherein said chemotactic hexapeptide unit is --VGVAPG--, and said chemotactic nonapeptide sequences are --AGvPGFGVG-- and --GFGVGAGVP--.
Claim 21
Dependent Claim
157 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PR.sub.2 R.sub.3 G--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; R 2 is such a residue selected from the group consisting of Ala and Gly; R 3 is such a residue selected from the group consisting of Phe, Leu, Ile, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer from 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 22
Dependent Claim
157 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PR.sub.2 R.sub.3 G--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; R 2 is such a residue selected from the group consisting of Ala and Gly; R 3 is such a residue selected from the group consisting of Phe, Leu, Ile, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer from 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 23
Dependent Claim
30 words
The bioelastomer of claim 12, which further comprises a fibroblastic chemotactic hexapeptide or nonapeptide unit or repeating units in an amount sufficient to impart fibroblastic chemotactic properties to said bioelastomers.
Claim 24
Independent Claim
125 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, and wherein said repeating units exist in a conformation having a β-turn, which comprises incorporating into said bioelastomer a tetrapeptide or pentapeptide unit or mixtures thereof or repeating units thereof, capable of adjusting the temperature at which elastomeric force of the bioelastomer develops, in an amount sufficient to adjust the delvelopment of elastomeric force of said bioelastomer, with the proviso that the elasticity of the bioelastomer is retained.
Claim 25
Independent Claim
125 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, and wherein said repeating units exist in a conformation having a β-turn, which comprises incorporating into said bioelastomer a tetrapeptide or pentapeptide unit or mixtures thereof or repeating units thereof, capable of adjusting the temperature at which elastomeric force of the bioelastomer develops, in an amount sufficient to adjust the delvelopment of elastomeric force of said bioelastomer, with the proviso that the elasticity of the bioelastomer is retained.
Claim 26
Independent Claim
168 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PR.sub.2 R.sub.3 G--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; R 2 is such a residue selected from the group consisting of Ala and Gly; R 3 is such a residue selected from the group consisting of Phe, Leu, Ile, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer from 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 27
Independent Claim
168 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PR.sub.2 R.sub.3 G--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; R 2 is such a residue selected from the group consisting of Ala and Gly; R 3 is such a residue selected from the group consisting of Phe, Leu, Ile, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer from 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 28
Dependent Claim
123 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PGG--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer from 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 29
Dependent Claim
123 words
A bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PGG--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer from 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 30
Independent Claim
134 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PGG--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer form 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 31
Independent Claim
134 words
A method of adjusting the temperature of elastomeric force development of a bioelastomer containing repeating units selected from the group consisting of elastomeric tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a β-turn which comprises a polypentapeptide unit of the formula: --R.sub.1 PGG--.sub.n wherein R 1 is a peptide-producing residue selected from the group consisting of Phe, Leu, Ils, and Val; P is a L-proline-producing residue, and G is a glycine-producing residue, and n is an integer form 1 to 200, in an amount sufficient to adjust the development of elastomeric force of said bioelastomer to a predetermined temperature.
Claim 32
Dependent Claim
9 words
The bioelastomer of claim 1, which is substantially cross-linked.
Claim 33
Dependent Claim
9 words
The bioelastomer of claim 3, which is substantially cross-linked.
Claim 34
Dependent Claim
9 words
The bioelastomer of claim 5, which is substantially cross-linked.
Claim 35
Dependent Claim
9 words
The bioelastomer of claim 7, which is substantially cross-linked.
Claim 36
Dependent Claim
9 words
The bioelastomer of claim 9, which is substantially cross-linked.
Claim 37
Dependent Claim
9 words
The bioelastomer of claim 12, which is substantially cross-linked.
Claim 38
Dependent Claim
9 words
The bioelastomer of claim 16, which is substantially cross-linked.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-08 | 1992-05-09 | 1992-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-08 | 1996-05-09 | 1996-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-08 | 2000-05-09 | 2000-11-08 | $7700.00 | Window Closed / Lapsed |