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US4780475A
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Preparation for the prevention of catabolism
Assignee: Novartis AG
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Filing: 1986-12-22
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Granted: 1988-10-25
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Expires: 2006-12-22
Abstract
Abstract Prevention of catabolism and increasing protein synthesis in a subject undergoing stress with compositions containing isoleucine, leucine and valine.
Inventors
- 👤 Frank B. Cerra
- 👤 Ronald J. Amen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:04
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K31/33; A61K31/395; A61K31/40; A61K31/403; A61K31/404; A61K31/405
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
84 words
A method of preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress, which comprises administering enterally to the subject 1.25 to 3.25 grams of essential and non-essential amino acids per kilogram of subject body weight per day, wherein the amino acids comprise by weight of total amino acids 40 to 50% isoleucine, leucine and valine in a ratio by weight of 0.5 to 1.5 parts of isoleucine to 1.5 to 2.5 parts of leucine to 0.5 to 1.5 parts of valine.
Claim 2
Independent Claim
84 words
A method of preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress, which comprises administering enterally to the subject 1.25 to 3.25 grams of essential and non-essential amino acids per kilogram of subject body weight per day, wherein the amino acids comprise by weight of total amino acids 40 to 50% isoleucine, leucine and valine in a ratio by weight of 0.5 to 1.5 parts of isoleucine to 1.5 to 2.5 parts of leucine to 0.5 to 1.5 parts of valine.
Claim 3
Dependent Claim
24 words
A method according to claim 1, wherein the amino acids comprise by weight of total amino acids 40 to 45% isoleucine, leucine and valine.
Claim 4
Dependent Claim
25 words
A method according to claim 1, in which 1.5 to 2.5 grams of amino acids per kilogram of subject body weight are administered per day.
Claim 5
Dependent Claim
25 words
A method according to claim 1, in which 1.5 to 2.0 grams of amino acids per kilogram of subject body weight are administered per day.
Claim 6
Dependent Claim
22 words
A method according to claim 3, in which the ratio of isoleucine to leucine to valine is 1 to 2 to 1.
Claim 7
Dependent Claim
94 words
A method according to claim 1, in which the amino acids comprise per 100 parts of total amino acids 11.0 parts of L-isoleucine; 22.0 parts of L-leucine; 11.0 parts of valine; 1.5 parts of L-tryptophan; 4.0 parts of L-phenylalanine; 3.0 parts of L-methionine; 6.5 parts of L-lysine; 5.0 parts of L-threonine; 7.0 parts of L-arginine; 0.7 part of L-tyrosine; 1.0 part of L-cysteine; 5.5 parts of L-alanine; 7.8 parts of L-glutamic acid; 3.5 parts of L-aspartic acid; 3.5 parts of L-histidine; 2.0 parts of L-serine; 3.0 parts of glycine and 2.0 parts of L-proline.
Claim 8
Dependent Claim
91 words
A pharmaceutical composition for enteral administration in preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress which comprises essential and non-essential amino acids in an amount sufficient to provide 1.25 to 3.25 grams of amino acids per kilogram of subject body weight per day, wherein the amino acids comprise by weight of total amino acids 40 to 50% isoleucine, leucine and valine in a ratio by weight of 0.5 to 1.5 parts of isoleucine to 1.5 to 2.5 parts of leucine to 0.5 to 1.5 parts of valine.
Claim 9
Dependent Claim
91 words
A pharmaceutical composition for enteral administration in preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress which comprises essential and non-essential amino acids in an amount sufficient to provide 1.25 to 3.25 grams of amino acids per kilogram of subject body weight per day, wherein the amino acids comprise by weight of total amino acids 40 to 50% isoleucine, leucine and valine in a ratio by weight of 0.5 to 1.5 parts of isoleucine to 1.5 to 2.5 parts of leucine to 0.5 to 1.5 parts of valine.
Claim 10
Dependent Claim
25 words
A pharmaceutical composition according to claim 7, wherein the amino acids comprise by weight of total amino acids 40% to 45% isoleucine, leucine and valine.
Claim 11
Dependent Claim
25 words
A composition according to claim 7, in which 1.5 to 2.5 grams of amino acids per kilogram of subject body weight are administered per day.
Claim 12
Dependent Claim
25 words
A composition according to claim 7, in which 1.5 to 2.0 grams of amino acids per kilogram of subject body weight are administered per day.
Claim 13
Dependent Claim
22 words
A composition according to claim 7, in which the ratio of isoleucine to leucine to valine is 1 to 2 to 1.
Claim 14
Dependent Claim
30 words
An enteral preparation comprising a composition according to claim 7 and carbohydrate and fat in an amount effective for the treatment of the stressed subject and an aqueous carrier therefor.
Claim 15
Dependent Claim
23 words
A composition according to claim 12, in which vitamins and minerals in amounts effective for the treatment of the stressed subject are administered.
Claim 16
Dependent Claim
94 words
A composition according to claim 7, in which the amino acids comprise per 100 parts of total amino acids, 11.0 parts of L-isoleucine; 22.0 parts of L-leucine; 11.0 parts of valine; 1.5 parts of L-tryptophan; 4.0 parts of L-phenylalanine; 3.0 parts of L-methionine; 6.5 parts of L-lysine; 5.0 parts of L-threonine; 7.0 parts of L-arginine; 0.7 parts of L-tyrosine; 1.0 part of L-cysteine; 5.5 parts of L-alanine; 7.8 parts of L-glutamic acid; 3.5 parts of L-aspartic acid; 3.5 parts of L-histidine; 2.0 parts of L-serine; 3.0 parts of glycine and 2.0 parts of L-proline.
Claim 17
Dependent Claim
91 words
A composition according to claim 7 in which the amino acids comprise per unit packaged form 1.6 grams of L-isoleucine; 3.3 grams of L-leucine; 1.6 grams of valine; 0.2 grams of L-tryptophan; 0.6 grams of L-phenylalanine; 0.4 grams of L-methionine; 1.0 grams of L-lysine; 0.8 grams of L-threonine; 1.0 grams of L-arginine; 0.1 grams of L-tyrosine; 0.2 grams of L-cysteine; 0.8 grams of L-alanine; 1.2 grams of L-glutamic acid; 0.5 grams of L-aspartic acid; 0.5 grams of L-histidine; 0.3 grams of L-serine; 0.4 grams of glycine and 0.3 grams of L-proline.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-25 | 2000-04-25 | 2000-10-25 | $7700.00 | Window Closed / Lapsed |