Abstract This invention introduces a new class of devices for detecting the presence of biological molecules. The construction principle of the device involves the direct introduction of small monomers of macromolecules into the surface layer of a semiconductor, for example by doping at the gate-area of a field effect transistor (or any other similar suitable electronic device, also on carbon basis). There are a few biological monomers which pair specifically enough for a selective measurement, such as nucleotides (or portions thereof, e.g. adenine, thymine, guanine, cytosine and uracil). This invention leads to substantial improvement of biosensors, as there should be: Better signal to noise ratio, and options for: reading of nucleotide sequences, better process control, and new synthesis possibilities (e.g. modified Merrifield Synthesis). The invention also offers the potential to construct cybernetic systems and true biochips.
A field effect device for sensing biological monomers which pair with high specificity with complementary biological monomers comprising: a semiconductor body having a first doping polarity; a source region and a drain region each having a second doping polarity and being disposed in said semiconductor body, and said source and said drain regions defining an area in said semiconductor body between said source region and said drain region; an insulated semiconductor gate overlying at least a portion of said area between said source and drain regions, said insulated semiconductor gate being doped with complementary biological monomers wherein the conductivity of said field effect device is modulated by the presence of biological monomers when said biological monomers are exposed to said insulated semiconductor gate.
Claim 2
Dependent Claim
123 words
A field effect device for sensing biological monomers which pair with high specificity with complementary biological monomers comprising: a semiconductor body having a first doping polarity; a source region and a drain region each having a second doping polarity and being disposed in said semiconductor body, and said source and said drain regions defining an area in said semiconductor body between said source region and said drain region; an insulated semiconductor gate overlying at least a portion of said area between said source and drain regions, said insulated semiconductor gate being doped with complementary biological monomers wherein the conductivity of said field effect device is modulated by the presence of biological monomers when said biological monomers are exposed to said insulated semiconductor gate.
Claim 3
Dependent Claim
23 words
A device according to claim 1 wherein said complementary biological monomer is selected from the group consisting of a purine, pyrimidine and nucleotide.
Claim 4
Dependent Claim
30 words
A device according to claim 1 wherein some of the complementary biological monomers are disposed on the surface of said insulated semiconductor gate to facilitate pairing with said biological monomers.
Claim 5
Dependent Claim
23 words
A device as in claim 1 wherein said insulated semiconductor gate includes an organic semiconductor which is doped with said complementary biological monomer.