US4775678A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Clotrimazole cream
Assignee: Merck Sharp & Dohme LLC
•
Filing: 1986-05-08
•
Granted: 1988-10-04
•
Expires: 2006-05-08
Abstract
Abstract An oil-in-water cream or lotion emulsion formulation containing clotrimazole having improved antifungal properties containing various amounts of clotrimazole, petrolatum, cetearyl alcohol, propylene glycol, and ceteth-20, with or without other additional ingredients.
Inventors
- 👤 Ching-Chiang Su
- 👤 Joel A. Sequeira
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:49
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/494; A61K8/4946; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K8/02; A61K8/04; A61K8/06; A61K8/062; A61K9/00; A61K9/0012; A61K9/0014; A61Q; A61Q17/00; A61Q17/005; A61Q19/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
52 words
An oil-in-water cream base antifungal percutaneous composition comprising: ______________________________________
0.5 mg clotrimazole;
150 mg petrolatum;
72 mg cetearyl alcohol;
100 mg propylene glycol;
22.5 mg ceteth-20
60 mg mineral oil
10 mg benzyl alcohol;
0.35 mg anhydrous dibasic sodium phosphate;
5 mg monobasic sodium phosphate; and
water q.s. to 1 gram.
______________________________________
Claim 2
Dependent Claim
52 words
An oil-in-water cream base antifungal percutaneous composition comprising: ______________________________________
0.5 mg clotrimazole;
150 mg petrolatum;
72 mg cetearyl alcohol;
100 mg propylene glycol;
22.5 mg ceteth-20
60 mg mineral oil
10 mg benzyl alcohol;
0.35 mg anhydrous dibasic sodium phosphate;
5 mg monobasic sodium phosphate; and
water q.s. to 1 gram.
______________________________________
Claim 3
Dependent Claim
52 words
An oil-in-water cream base anti-fungal percutaneous composition comprising: ______________________________________
0.1 mg clotrimazole;
150 mg petrolatum;
72 mg cetearyl alcohol;
100 mg propylene glycol;
22.5 mg ceteth-20;
60 mg mineral oil;
10 mg benzyl alcohol;
0.35 mg anhydrous dibasic sodium phosphate;
5 mg monobasic sodium phosphate; and
water q.s. to 1 gram
______________________________________
Claim 4
Dependent Claim
52 words
An oil-in-water cream base anti-fungal percutaneous composition comprising: ______________________________________
0.1 mg clotrimazole;
150 mg petrolatum;
72 mg cetearyl alcohol;
100 mg propylene glycol;
22.5 mg ceteth-20;
60 mg mineral oil;
10 mg benzyl alcohol;
0.35 mg anhydrous dibasic sodium phosphate;
5 mg monobasic sodium phosphate; and
water q.s. to 1 gram
______________________________________
Claim 5
Dependent Claim
59 words
An oil-in-water cream base antifungal percutaneous composition comprising the following ingredients in the indicated proportions: ______________________________________
(a) 0.1 to 100 mg clotrimazole;
(b) 100 to 300 mg petrolatum;
(c) 50 to 120 mg cetearyl alcohol;
(d) 50 to 200 mg propylene glycol;
(e) 15 to 30 mg ceteth 20; and
(f) pharmaceutically acceptable aqueous solvents to 1 gram.
______________________________________
Claim 6
Dependent Claim
59 words
An oil-in-water cream base antifungal percutaneous composition comprising the following ingredients in the indicated proportions: ______________________________________
(a) 0.1 to 100 mg clotrimazole;
(b) 100 to 300 mg petrolatum;
(c) 50 to 120 mg cetearyl alcohol;
(d) 50 to 200 mg propylene glycol;
(e) 15 to 30 mg ceteth 20; and
(f) pharmaceutically acceptable aqueous solvents to 1 gram.
______________________________________
References Cited (Backward Citations)
US3660577A
Cited
US4444762A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-04 | 1992-04-04 | 1992-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-04 | 1996-04-04 | 1996-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-04 | 2000-04-04 | 2000-10-04 | $7700.00 | Window Closed / Lapsed |