Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors

Claim 1

A compound of the formula ##STR88## wherein R 1 is hydrogen, lower alkyl, benzyl; R 2 is hydrogen, halogen, lower alkyl, lower alkoxy; Alk is an unbranched or branched alkylene chain of 1 to 8 carbon; Y is hydroxyl and esters thereof formed with an alkanoic acid of 1 to 6 carbon atoms or phenylalkanoic acid of 7-12 carbon atoms, alkoxy wherein with Alk the number of carbon atoms ranges from 2 to 10, oxo forming a ketone with Alk, di-(lower alkyl)amino, --CO 2 H, --CO 2 R 3 wherein R 3 is lower alkyl; ##STR89## wherein R 4 is hydrogen, lower a alkyl, benzyl, cyclohexyl, --(CH 2 ) n CO 2 R 6 wherein n is the integer 1 to 8 and the alkylene chain (CH 2 ) n is unbranched or branched and R 6 is hydrogen or lower alkyl; R 5 is hydrogen, lower alkyl, benzyl, adamentanamyl, cycloalkyl of 3 to 7 carbon atoms wherein the cycloalkyl ring is unsubstituted or substituted with lower alkyl or lower alkoxy; R 4 and R 5 are joined together to form 1-morpholinyl, piperidinyl optionally substituted with --CO 2 R 7 is hydrogen or lower alkyl, 1-(4-phenylpiperazinyl) wherein phenyl is unsubstituted or independently substituted with up to 2 halogen, lower alkyl, or lower alkoxy groups; ##STR90## wherein R 8 is lower alkyl; ##STR91## wherein R 8 is lower alkyl; ##STR92## wherein R 9 is lower alkyl, cycloalkyl of 5 to 7 carbon atoms; --SO 2 --phenyl wherein phenyl is unsubstituted or independently substituted with up to 2 halogen, lower alkyl or lower alkoxy; or a pharmaceutically acceptable salt thereof.