US3932407A
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US
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Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
Assignee: Bristol Myers Co
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Filing: 1974-11-06
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Granted: 1976-01-13
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Expires: 1994-11-06
Abstract
Abstract Optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-ones and 6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]-quinazolin-2-ones or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive and/or bronchodilator agents in mammals, including humans.
Inventors
- 👤 Warren Neil Beverung, Jr.
- 👤 Anthony Partyka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 07:33
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07C; C07C205/00; C07C205/07; C07C205/11; C07C205/12; C07C205/13; C07C205/19; C07D239/00; C07D239/70; C07D239/72; C07D239/78; C07D239/80
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
102 words
The compound having the formula ##SPC29## in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3 H, hydroxy, (lower)alkyl or (lower) alkoxy, nitro, amino or phenyl, R 2 and R 3 when alike are hydrogen, bromo, chloro, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
102 words
The compound having the formula ##SPC29## in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3 H, hydroxy, (lower)alkyl or (lower) alkoxy, nitro, amino or phenyl, R 2 and R 3 when alike are hydrogen, bromo, chloro, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
100 words
The compound of claim 1 having the formula ##SPC30##in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3 H. hydroxy, (lower)alkyl or (lower)alkoxy or phenyl, R 2 and R 3 when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid salt thereof.
Claim 4
Dependent Claim
94 words
The compound of claim 1 having the formula ##SPC31## in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, CF 3 , SO 3 H, fluoro, hydroxy, nitro, amino, phenyl, (lower)alkyl or (lower)alkoxy, R 2 and R 3 when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-; or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
86 words
The compound of claim 3 having the formula ##SPC32## in which R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, nitro, amino, CF 3 , SO 3 H, hydroxy, (lower)alkoxy or (lower)alkyl, R 2 and R 3 when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-; or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
48 words
The compound of claim 2 having the formula ##SPC33## in which R 2 and R 3 are alike or different and are H, hydroxy, (lower)alkoxy of 1 to 3 carbon atoms or (lower)alkyl of 1 to 3 carbon atoms, chloro, or fluoro; or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
34 words
The compound of claim 2 having the formula ##SPC34## in which R 2 and R 3 are alike or different and each is H, Cl, methoxy, methyl or hydroxy; or the hydrochloride salt thereof.
Claim 8
Dependent Claim
19 words
The compound of claim 6 in which R 2 and R 3 are hydrogen; or the hydrochloride salt thereof.
Claim 9
Dependent Claim
19 words
The compound of claim 6 in which R 2 and R 3 are methoxy; or the hydrochloride salt thereof.
Claim 10
Dependent Claim
19 words
The compound of claim 6 in which R 2 and R 3 are methyl; or the hydrochloride salt thereof.
Claim 11
Dependent Claim
21 words
The compound of claim 6 in which R 2 is H and R 3 is methoxy; or the hydrochloride salt thereof.
Claim 12
Dependent Claim
21 words
The compound of claim 6 in which R 2 is methoxy and R 3 is hydrogen; or the hydrochloride salt thereof.
Claim 13
Dependent Claim
21 words
The compound of claim 6 in which R 2 is hydrogen and R 3 is methyl; or the hydrochloride salt thereof.
Claim 14
Dependent Claim
21 words
The compound of claim 6 in which R 2 is methyl and R 3 is hydrogen; or the hydrochloride salt thereof.
Claim 15
Dependent Claim
21 words
The compound of claim 4 in which R 2 is nitro and R 3 is methyl; or the hydrochloride salt thereof.
Claim 16
Dependent Claim
22 words
The compound of claim 4 in which R 2 and R 3 when taken together are -CH=CH-CH=CH-; or the hydrochloride salt thereof.
Claim 17
Dependent Claim
12 words
The compound having the formula ##SPC35## or an acid addition salt thereof.
Claim 18
Dependent Claim
12 words
The compound having the formula ##SPC35## or an acid addition salt thereof.
Claim 19
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 16.
Claim 20
Dependent Claim
12 words
The compound having the formula ##SPC36## or an acid addition salt thereof.
Claim 21
Dependent Claim
12 words
The compound having the formula ##SPC36## or an acid addition salt thereof.
Claim 22
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 18.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-12 | 1979-07-14 | 1980-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-12 | 1983-07-14 | 1984-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-12 | 1987-07-14 | 1988-01-13 | $7700.00 | Window Closed / Lapsed |