Patent US1921223A successfully refreshed from Google Patents.
Patent US3932407A successfully refreshed from Google Patents.
US3932407A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
Assignee: Bristol Myers Co
•
Filing: 1974-11-06
•
Granted: 1976-01-13
•
Expires: 1994-11-06
Abstract
Abstract Optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-ones and 6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]-quinazolin-2-ones or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive and/or bronchodilator agents in mammals, including humans.
Inventors
- 👤 Warren Neil Beverung, Jr.
- 👤 Anthony Partyka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:45
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07C; C07C205/00; C07C205/07; C07C205/11; C07C205/12; C07C205/13; C07C205/19; C07D239/00; C07D239/70; C07D239/72; C07D239/78; C07D239/80
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
102 words
The compound having the formula ##SPC29## in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3 H, hydroxy, (lower)alkyl or (lower) alkoxy, nitro, amino or phenyl, R 2 and R 3 when alike are hydrogen, bromo, chloro, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
102 words
The compound having the formula ##SPC29## in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3 H, hydroxy, (lower)alkyl or (lower) alkoxy, nitro, amino or phenyl, R 2 and R 3 when alike are hydrogen, bromo, chloro, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
100 words
The compound of claim 1 having the formula ##SPC30##in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3 H. hydroxy, (lower)alkyl or (lower)alkoxy or phenyl, R 2 and R 3 when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid salt thereof.
Claim 4
Dependent Claim
94 words
The compound of claim 1 having the formula ##SPC31## in which R 1 is H, phenyl or (lower)alkyl, R 2 and R 3 when different are hydrogen, chloro, bromo, CF 3 , SO 3 H, fluoro, hydroxy, nitro, amino, phenyl, (lower)alkyl or (lower)alkoxy, R 2 and R 3 when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-; or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
86 words
The compound of claim 3 having the formula ##SPC32## in which R 2 and R 3 when different are hydrogen, chloro, bromo, fluoro, nitro, amino, CF 3 , SO 3 H, hydroxy, (lower)alkoxy or (lower)alkyl, R 2 and R 3 when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2 and R 3 are methylenedioxy or the moiety -CH=CH-CH=CH-; or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
48 words
The compound of claim 2 having the formula ##SPC33## in which R 2 and R 3 are alike or different and are H, hydroxy, (lower)alkoxy of 1 to 3 carbon atoms or (lower)alkyl of 1 to 3 carbon atoms, chloro, or fluoro; or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
34 words
The compound of claim 2 having the formula ##SPC34## in which R 2 and R 3 are alike or different and each is H, Cl, methoxy, methyl or hydroxy; or the hydrochloride salt thereof.
Claim 8
Dependent Claim
19 words
The compound of claim 6 in which R 2 and R 3 are hydrogen; or the hydrochloride salt thereof.
Claim 9
Dependent Claim
19 words
The compound of claim 6 in which R 2 and R 3 are methoxy; or the hydrochloride salt thereof.
Claim 10
Dependent Claim
19 words
The compound of claim 6 in which R 2 and R 3 are methyl; or the hydrochloride salt thereof.
Claim 11
Dependent Claim
21 words
The compound of claim 6 in which R 2 is H and R 3 is methoxy; or the hydrochloride salt thereof.
Claim 12
Dependent Claim
21 words
The compound of claim 6 in which R 2 is methoxy and R 3 is hydrogen; or the hydrochloride salt thereof.
Claim 13
Dependent Claim
21 words
The compound of claim 6 in which R 2 is hydrogen and R 3 is methyl; or the hydrochloride salt thereof.
Claim 14
Dependent Claim
21 words
The compound of claim 6 in which R 2 is methyl and R 3 is hydrogen; or the hydrochloride salt thereof.
Claim 15
Dependent Claim
21 words
The compound of claim 4 in which R 2 is nitro and R 3 is methyl; or the hydrochloride salt thereof.
Claim 16
Dependent Claim
22 words
The compound of claim 4 in which R 2 and R 3 when taken together are -CH=CH-CH=CH-; or the hydrochloride salt thereof.
Claim 17
Dependent Claim
12 words
The compound having the formula ##SPC35## or an acid addition salt thereof.
Claim 18
Dependent Claim
12 words
The compound having the formula ##SPC35## or an acid addition salt thereof.
Claim 19
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 16.
Claim 20
Dependent Claim
12 words
The compound having the formula ##SPC36## or an acid addition salt thereof.
Claim 21
Dependent Claim
12 words
The compound having the formula ##SPC36## or an acid addition salt thereof.
Claim 22
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 18.
References Cited (Backward Citations)
US3048587A
Cited
US3257401A
Cited
US3600390A
Cited
DE2025248A1
Cited
US3598823A
Cited
US3621025A
Cited
US3745216A
Cited
US3790576A
Cited
US3833588A
Cited
US3859289A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-12 | 1979-07-14 | 1980-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-12 | 1983-07-14 | 1984-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-12 | 1987-07-14 | 1988-01-13 | $7700.00 | Window Closed / Lapsed |