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US4769318A
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Additive solution for blood preservation and activation
Assignee: Japanese Red Cross Society
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Filing: 1987-04-15
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Granted: 1988-09-06
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Expires: 2007-04-15
Abstract
Abstract There is disclosed an additive solution for blood preservation and activation, which comprises a phosphoenolpyruvic acid represented by the following formula (I): <IMAGE> (I) wherein R1 represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, R2 and R3 represent a hydrogen atom, an alkali metal or an alkyl group having 1 to 12 carbon atoms respectively, a saccharide, adenine and an organic acid and/or a pharmaceutically acceptable alkali metal salt of the organic acid.
Inventors
- 👤 Naotaka Hamasaki
- 👤 Shigeru Sasakawa
- 👤 Masayuki Shiba
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:58
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
98 words
An additive solution for blood preservation and activation, comprising 10 to 100 mmole/liter of a phosphoenolpyruvic acid represented by the following formula (I): ##STR3## wherein R 1 represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, R 2 and R 3 each independently represent a hydrogen atom, an alkali metal or an alkyl group having 1 to 12 carbon atoms; 100 to 300 mmole/liter of a saccharide, 0.2 to 2 mmole/liter of adenine; and 3 to 50 mmole/liter of an organic acid and/or a pharmaceutically acceptable alkali metal salt of said organic acid.
Claim 2
Dependent Claim
98 words
An additive solution for blood preservation and activation, comprising 10 to 100 mmole/liter of a phosphoenolpyruvic acid represented by the following formula (I): ##STR3## wherein R 1 represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, R 2 and R 3 each independently represent a hydrogen atom, an alkali metal or an alkyl group having 1 to 12 carbon atoms; 100 to 300 mmole/liter of a saccharide, 0.2 to 2 mmole/liter of adenine; and 3 to 50 mmole/liter of an organic acid and/or a pharmaceutically acceptable alkali metal salt of said organic acid.
Claim 3
Dependent Claim
21 words
The additive solution for blood preservation and activation according to claim 1, wherein said saccharide is sucrose, maltose, galactose or mannitol.
Claim 4
Dependent Claim
33 words
The additive solution for blood preservation and activation according to claim 1, wherein said organic acid is citric acid and said pharmaceutically acceptable alkali metal salt of the organic acid is sodium citrate.
Claim 5
Dependent Claim
50 words
The additive solution for blood preservation and activation according to claim 1, comprising an aqueous solution containing 10 to 100 mmole/liter of monosodium phosphoenolpyruvate, 100 to 300 mmole/liter of sucrose, maltose or mannitol, 0.2 to 2 mmole/liter of adenine and 3 to 50 mmole/liter of citric acid and/or trisodium citrate.
Claim 6
Dependent Claim
23 words
The additive solution for blood preservation and activation according to claim 4, wherein an amount of monosodium phosphoenolpyruvate is 50 to 100 mmole/liter.
Claim 7
Dependent Claim
32 words
A method for blood preservation and activation comprising mixing an effective amount of the additive solution according to claim 1 and blood and thereafter carrying out an incubation treatment immediately before transfusion.
Claim 8
Dependent Claim
18 words
The additive solution of claim 4 further comprising sodium chloride added to adjust osmolarity of the aqueous solution.
Claim 9
Dependent Claim
27 words
The method of claim 6 wherein the incubation treatment to be carried out immediately before transfusion comprises incubating the additive solution and blood mixture at 37° C.
References Cited (Backward Citations)
US4476221A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-06 | 1992-03-07 | 1992-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-06 | 1996-03-07 | 1996-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-06 | 2000-03-07 | 2000-09-06 | $7700.00 | Window Closed / Lapsed |