US4769233A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Structure and properties of modified interferons
Assignee: GD Searle LLC
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Filing: 1985-05-03
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Granted: 1988-09-06
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Expires: 2005-05-03
Abstract
Abstract A composition of matter comprising a polypeptide of the formula: A-R1-B-R2-22-C wherein: A is the amino acid sequence 1-16 of human beta interferon; R1 is cysteine, serine or alanine; B is the amino acid sequence 18-31 of human beta interferon; R2-22 are naturally occurring amino acids; C is the amino acid sequence 53-166 of human beta interferon.
Inventors
- 👤 Leslie D. Bell
- 👤 Paul G. Boseley
- 👤 Alan G. Porter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:35
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/555; C07K14/565; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/142
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
44 words
A modified beta interferon comprising a beta interferon wherein amino acids 36 to 48 of said beta interferon are replaced by amino acids 34 to 46 of alpha 1 interferon and the cysteine at position 17 of said beta interferon is replaced by serine.
Claim 2
Dependent Claim
44 words
A modified beta interferon comprising a beta interferon wherein amino acids 36 to 48 of said beta interferon are replaced by amino acids 34 to 46 of alpha 1 interferon and the cysteine at position 17 of said beta interferon is replaced by serine.
Claim 3
Dependent Claim
44 words
A modified beta interferon comprising a beta interferon wherein amino acids 36 to 40 of said beta interferon are replaced by amino acids 34 to 38 of alpha 1 interferon and the cysteine at position 17 of said beta interferon is replaced by serine.
Claim 4
Dependent Claim
44 words
A modified beta interferon comprising a beta interferon wherein amino acids 36 to 40 of said beta interferon are replaced by amino acids 34 to 38 of alpha 1 interferon and the cysteine at position 17 of said beta interferon is replaced by serine.
Claim 5
Dependent Claim
30 words
A modified beta interferon comprising a beta interferon wherein amino acids 42 to 48 of said beta interferon are replaced by amino acids 40 to 46 of alpha 1 interferon.
Claim 6
Dependent Claim
30 words
A modified beta interferon comprising a beta interferon wherein amino acids 42 to 48 of said beta interferon are replaced by amino acids 40 to 46 of alpha 1 interferon.
Claim 7
Dependent Claim
30 words
A modified beta interferon comprising a beta interferon wherein amino acids 36 to 48 of said beta interferon are replaced by amino acids 34 to 46 of alpha 1 interferon.
Claim 8
Dependent Claim
30 words
A modified beta interferon comprising a beta interferon wherein amino acids 36 to 48 of said beta interferon are replaced by amino acids 34 to 46 of alpha 1 interferon.
Claim 9
Dependent Claim
40 words
A pharmaceutical composition for use in treating viral infection or neoplastic disease or for stimulating the immune system in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 1 admixed with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
40 words
A pharmaceutical composition for use in treating viral infection or neoplastic disease or for stimulating the immune system in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 4 admixed with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
34 words
A pharmaceutical composition for use in treating viral infection or neoplastic disease in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 2 admixed with a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
30 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 1.
Claim 13
Dependent Claim
30 words
A method of regulating cell growth in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 1.
Claim 14
Dependent Claim
31 words
A method of regulating the immune system in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 1.
Claim 15
Dependent Claim
30 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 4.
Claim 16
Dependent Claim
30 words
A method of regulating cell growth in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 4.
Claim 17
Dependent Claim
31 words
A method of regulating the immune system in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 4.
Claim 18
Dependent Claim
30 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 2.
Claim 19
Dependent Claim
30 words
A method of regulating cell growth in an animal in need of such treatment comprising the administration of an effective therapeutic amount of a modified beta interferon of claim 2.
References Cited (Backward Citations)
US4569908A
Cited
US4588585A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-06 | 1992-03-07 | 1992-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-06 | 1996-03-07 | 1996-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-06 | 2000-03-07 | 2000-09-06 | $7700.00 | Window Closed / Lapsed |