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US4767783A
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Gallstone dissolver
Assignee: Kao Corp
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Filing: 1986-08-13
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Granted: 1988-08-30
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Expires: 2006-08-13
Abstract
Abstract A gallstone dissolver comprises the following active ingredients (A) and (B); (A) a compound selected from the group consisting of fatty acid monoglycerides of C-6 to C-12, fatty acid diglycerides in liquid phase at 30° C., fatty acid triglycerides in liquid phase at 30° C., and fatty acids in liquid phase at 30° C., and (B) a monoterpene. The coexistence of the fatty acid and monoterpene in the gallstone dissolver accelerates the sulubility and dissolving velocity of cholesterol gallstones. A nonionic surfactant such as a polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, etc. may also be added to the above dissolver to further improve the performance of the dissolver.
Inventors
- 👤 Kenji Hara
- 👤 Jhoshin Okada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/225
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
69 words
A gallstone dissolver which comprises the following ingredients (A) and (B): (A) 20 to 40 percent by volume of a fatty acid monoglyceride selected from the group consisting of monoglyceride hexanoate, monoglyceride heptanoate, monoglyceride octanoate, monoglyceride nonanoate, monoglyceride decanoate, monoglyceride undecanoate, mooglyceride dodecanoate, and (B) 80 to 60 percent by volume of a monoterpene selected from the group consisting of limonene, pinene, dipentene, terpineol, phellandrene, perilaldehyde, carvone, and menthone.
Claim 2
Dependent Claim
69 words
A gallstone dissolver which comprises the following ingredients (A) and (B): (A) 20 to 40 percent by volume of a fatty acid monoglyceride selected from the group consisting of monoglyceride hexanoate, monoglyceride heptanoate, monoglyceride octanoate, monoglyceride nonanoate, monoglyceride decanoate, monoglyceride undecanoate, mooglyceride dodecanoate, and (B) 80 to 60 percent by volume of a monoterpene selected from the group consisting of limonene, pinene, dipentene, terpineol, phellandrene, perilaldehyde, carvone, and menthone.
Claim 3
Dependent Claim
18 words
The gallstone dissolver according to claim 1 in which the ingredient (A) is monoglyceride octanoate or monoglyceride decanoate.
Claim 4
Dependent Claim
18 words
The gallstone dissolver according to claim 1 in which the monoterpene of ingredient (B) is limonene or menthone.
Claim 5
Dependent Claim
24 words
A gallstone dissolver according to claim 1, wherein said monoterpene is selected from the group consisting of limonene, pinene, terpineol, phellandrene, carvone, and methone.
Claim 6
Dependent Claim
24 words
A gallstone dissolver according to claim 1, wherein said monoterpene is selected from the group consisting of menthone, dipentene, terpineol, phellandrene, periladehyde and carvone.
Claim 7
Dependent Claim
21 words
A gallstone dissolver according to claim 1, wherein said monoterpene is selected from the group consisting of limonene, menthone, and carvone.
Claim 8
Dependent Claim
144 words
A gallstone dissolver which comprises the following ingredients (A), (B) and (C): (A) 20 to 40 percent by volume of a fatty acid glyceride selected from the group consisting of monoglyceride hexanoate, monoglyceride heptanoate, monoglyceride octanoate, monoglyceride nonanoate, monoglyceride decanoate, monoglyceride undecanoate, monoglyceride dodecanoate, (B) 80 to 60 percent by volume of a monoterpene selected from the group consisting of limonene, pinene, dipentene, terpineol, phellandrene, perilaldehyde, carvone, and menthone, and (C) 0.5 to 3 percent by weight of a nonionic surfactant selected from the group consisting of sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, coconut oil fatty acid ester, glycerin monostearate, glycerin monooleate, polyoxyethylene oleyl ether, polyoxyethylene hardened castor oil derivatives 60 moles on average of ethyleneoxide and polyethylene glycol stearate being added.
Claim 9
Dependent Claim
144 words
A gallstone dissolver which comprises the following ingredients (A), (B) and (C): (A) 20 to 40 percent by volume of a fatty acid glyceride selected from the group consisting of monoglyceride hexanoate, monoglyceride heptanoate, monoglyceride octanoate, monoglyceride nonanoate, monoglyceride decanoate, monoglyceride undecanoate, monoglyceride dodecanoate, (B) 80 to 60 percent by volume of a monoterpene selected from the group consisting of limonene, pinene, dipentene, terpineol, phellandrene, perilaldehyde, carvone, and menthone, and (C) 0.5 to 3 percent by weight of a nonionic surfactant selected from the group consisting of sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, coconut oil fatty acid ester, glycerin monostearate, glycerin monooleate, polyoxyethylene oleyl ether, polyoxyethylene hardened castor oil derivatives 60 moles on average of ethyleneoxide and polyethylene glycol stearate being added.
Claim 10
Dependent Claim
24 words
A gallstone dissolver according to claim 7, wherein said monoterpene is selected from the group consisting of limonene, pinene, terpineol, phellandrene, carvone and menthone.
Claim 11
Dependent Claim
24 words
A gallstone dissolver according to claim 7, wherein said monterpene is selected from the group consisting of menthone, dipentene, terpineol, phellandrene, periladehyde and carvone.
Claim 12
Dependent Claim
21 words
A gallstone dissolver according to claim 7, wherein said monoterpene is selected from the group consisting of limonene, menthone and carvone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-30 | 1992-02-29 | 1992-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-30 | 1996-02-29 | 1996-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-30 | 2000-02-29 | 2000-08-30 | $7700.00 | Window Closed / Lapsed |