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US4766379A
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Method for obtaining nuclear magnetic resonance information data
Assignee: Asahi Kasei Corp
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Filing: 1986-08-29
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Granted: 1988-08-23
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Expires: 2006-08-29
Abstract
Abstract A main magnetic field is applied to a target to excite the nuclear spin of a chosen type of atoms in a selected slice of the target. Subsequently, first and second gradient fields, which are parallel to the main magnetic field noted above and the strengths of which vary in the directions of respective first and second crossing axes in the slice, are applied to the target for predetermined period of time. Then, a readout magnetic gradient field, which is parallel to the first gradient field, and the strength of which varies in the direction of the first axis, is applied to the target to detect a free induction signal from the target. The detection of the free induction signal is repeatedly performed with a plurality of different strengths of the first and second gradient fields, whereby NMR data containing chemical shift data is obtained from the slice of the target noted above.
Inventors
- 👤 Toshiyuki Miyazaki
- 👤 Tohru Yamamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:26
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/485
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
230 words
A method for obtaining nuclear magnetic resonance information data containing chemical shift data from a selected slice of a target, comprising the steps of: placing said target in a main magnetic field and causing nuclear spin excitation of a selected type of atoms in said selected target slice defined in said magnetic field; applying to said target for a predetermined period of time first and second magnetic gradient fields parallel to said main magnetic field and having respective strengths varying along first and second axes crossing each other in said slice; subsequently applying to said target a readout magnetic gradient field parallel to said first magnetic gradient field and varying in strength along said first axis, to thereby encode spatial information in frequency along said first axis; detecting, in the presence of said readout magnetic gradient field, a free induction signal from said target after the lapse of a substantially constant period of time from said nuclear spin excitation; repeating a sequence of the foregoing steps a predetermined number of times while varying for each sequence the strength of said second magnetic gradient field, to thereby encode spatial information in phase along said second axis; and repeating at least once a series of said predetermined number of sequences while varying for each series the gradient field strength of said magnetic gradient field, to thereby encode chemical shift information in phase.
Claim 2
Independent Claim
230 words
A method for obtaining nuclear magnetic resonance information data containing chemical shift data from a selected slice of a target, comprising the steps of: placing said target in a main magnetic field and causing nuclear spin excitation of a selected type of atoms in said selected target slice defined in said magnetic field; applying to said target for a predetermined period of time first and second magnetic gradient fields parallel to said main magnetic field and having respective strengths varying along first and second axes crossing each other in said slice; subsequently applying to said target a readout magnetic gradient field parallel to said first magnetic gradient field and varying in strength along said first axis, to thereby encode spatial information in frequency along said first axis; detecting, in the presence of said readout magnetic gradient field, a free induction signal from said target after the lapse of a substantially constant period of time from said nuclear spin excitation; repeating a sequence of the foregoing steps a predetermined number of times while varying for each sequence the strength of said second magnetic gradient field, to thereby encode spatial information in phase along said second axis; and repeating at least once a series of said predetermined number of sequences while varying for each series the gradient field strength of said magnetic gradient field, to thereby encode chemical shift information in phase.
Claim 3
Dependent Claim
129 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, wherein the strength of said first magnetic gradient field is selected such that a rising portion of one of the free induction signals nearest to a cutoff of said first magnetic gradient field is substantially zero at the start of the free induction signal detection, and the period of said free induction signal detection is set to be longer than an interval T 1 which is the inverse of a desired chemical shift resolution 1/T 1 such that a detected value corresponding to a falling portion one of the free induction signal remotest from a cutoff of said first magnetic gradient field has a sufficiently small value at the end of the free induction signal detection.
Claim 4
Dependent Claim
106 words
The method for obtaining nuclear magnetic resonance information data according to claim 2, wherein the period of said free induction signal detection is set to 2T 1 ; a Fourier transform is performed on a detected free induction signal sample series; frequency components mΔω for m=0, 1, 2, . . . are derived from the frequency components mΔω/2, where m=0, 2, 4, . . . , obtained as a result of said Fourier transform; and a two-dimensional Fourier transform is performed on said derived frequency components with respect to the strengths of said first and second magnetic gradient fields to thereby separate each chemical shift data.
Claim 5
Dependent Claim
113 words
The method for obtaining nuclear magnetic resonance information data according to claim 2, wherein the period of said free induction signal detection is set to 2T 1 ; a Fourier transform is performed on a detected free induction signal sample series; data ρ(0) and ##EQU15## for m=1, 2, 3, . . ., where W 1 , W 2 and W 3 being weighting values, are derived from a data series ##EQU16## . . . obtained as a result of said Fourier transform; and a two-dimensional Fourier transform is performed on said derived data with respect to the strengths of said first and second magnetic gradient fields to thereby separate each chemical shift data.
Claim 6
Dependent Claim
48 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, wherein the period of detection of each free induction signal from said target is set such that the difference between the detected values at the start and end of said detection period is substantially zero.
Claim 7
Dependent Claim
32 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, wherein the detected values at the start and end of said detection period are made to be substantially zero.
Claim 8
Dependent Claim
32 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, 2 or 5, wherein said first magnetic gradient field is opposite in direction to said readout magnetic gradient field.
Claim 9
Dependent Claim
58 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, 2 or 5, wherein said first magnetic gradient field has the same direction as said readout magnetic gradient field and a 180° pulse is applied to said target between the application of said first and second magnetic gradient fields and said readout magnetic gradient field.
Claim 10
Dependent Claim
51 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, 2 or 5, wherein each chemical shift data is separated by effecting a three-dimensional Fourier transform of detected free induction signal with respect to sample series thereof, and strength series of said first and second magnetic gradient fields.
Claim 11
Dependent Claim
70 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, wherein the step for causing nuclear spin excitation includes a step for simultaneously applying a 180° pulse and a slice selection gradient field to said target and a step for applying, after a fixed interval from the application of said 180° pulse, a 90° pulse to said target simultaneously with application of the slice selection gradient field.
Claim 12
Dependent Claim
70 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, wherein the step for causing nuclear spin excitation includes a step for simultaneously applying a 90° pulse and a slice selection gradient field to said target and a step for applying, after a fixed interval from the application of said 90° pulse, a 180° pulse to said target simultaneously with application of the slice selection gradient field.
Claim 13
Dependent Claim
61 words
The method for obtaining nuclear magnetic resonance information data according to claim 1, wherein the step for causing nuclear spin excitation includes a step for applying a CHESS pulse to said target for a given period, a step for applying spoiling gradient fields and a step for simultaneously applying a 90° pulse and a slice selection gradient field to said target.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-23 | 1992-02-22 | 1992-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-23 | 1996-02-22 | 1996-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-23 | 2000-02-22 | 2000-08-23 | $7700.00 | Window Closed / Lapsed |