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US4764604A
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Derivatives of gamma-cyclodextrin
Assignee: Janssen Pharmaceutica NV
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Filing: 1986-02-27
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Granted: 1988-08-16
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Expires: 2006-02-27
Abstract
Abstract This invention relates to gamma -cyclodextrin ethers and mixed ethers wherein the ether substituents are C1-C6 alkyl, hydroxy C1-C6 alkyl, carboxy C1-C6 alkyl or (C1-C6 alkyloxycarbonyl) C1-C6 alkyl; provided that hydroxypropyl is not a sole substituent.
Inventors
- 👤 Bernd W. W. Muller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:27
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/06; B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
47 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 6 alkyl, hydroxy C 1 -C 6 alkyl, carboxy C 1 -C 6 -alkyl or (C 1 -C 6 alkyloxycarbonyl) C 1 -C 6 alkyl; provided that hydroxypropyl is not a sole substituent.
Claim 2
Dependent Claim
47 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 6 alkyl, hydroxy C 1 -C 6 alkyl, carboxy C 1 -C 6 -alkyl or (C 1 -C 6 alkyloxycarbonyl) C 1 -C 6 alkyl; provided that hydroxypropyl is not a sole substituent.
Claim 3
Dependent Claim
33 words
A γ-cyclodextrin ether or mixed ether according to claim 1 wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 -C 4 alkyl or carboxy C 1 -C 2 alkyl.
Claim 4
Dependent Claim
21 words
A γ-cyclodextrin derivative according to claim 1, wherein the ether substituents are methyl, ethyl, isopropyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, carboxymethyl or carboxyethyl.
Claim 5
Dependent Claim
56 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 -C 4 alkyl or carboxy C 1 -C 2 alkyl and wherein the degree of substitution is in the range of 0.125 to 3 and the average molar substitution is in the range of 0.125 to 10.
Claim 6
Dependent Claim
56 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 -C 4 alkyl or carboxy C 1 -C 2 alkyl and wherein the degree of substitution is in the range of 0.125 to 3 and the average molar substitution is in the range of 0.125 to 10.
Claim 7
Dependent Claim
33 words
A γ-cyclodextrin derivative according to claim 4, wherein the degree of substitution is in the range of 0.3 to 2 and the average molar substitution is in the range of 0.3 to 3.
Claim 8
Dependent Claim
47 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are methyl, ethyl, isopropyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, carboxymethyl or carboxyethyl and wherein the degree of substitution is in the range of 0.125 to 3 and the average molar substitution is in the range of 0.125 to 10.
Claim 9
Dependent Claim
47 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are methyl, ethyl, isopropyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, carboxymethyl or carboxyethyl and wherein the degree of substitution is in the range of 0.125 to 3 and the average molar substitution is in the range of 0.125 to 10.
Claim 10
Dependent Claim
33 words
A γ-cyclodextrin derivative according to claim 6, wherein the degree of substitution is in the range of 0.3 to 2 and the average molar substitution is in the range of 0.3 to 3.
Claim 11
Dependent Claim
19 words
A process for preparing a compound as defined in claim 1, characterized by reacting γ-cyclodextrin with an O-alkylating agent.
Claim 12
Dependent Claim
19 words
A process for preparing a compound as defined in claim 2, characterized by reacting γ-cyclodextrin with an O-alkylating agent.
Claim 13
Dependent Claim
19 words
A process for preparing a compound as defined in claim 3, characterized by reacting γ-cyclodextrin with an O-alkylating agent.
Claim 14
Dependent Claim
21 words
A process according to claim 9, wherein the process is conducted in a reaction-inert solvent in the presence of a base.
Claim 15
Dependent Claim
23 words
A process according to claim 9, wherein the process is conducted at a temperature in the range from 30° C. to 200° C.
Claim 16
Dependent Claim
21 words
A process according to claim 10, wherein the process is conducted in a reaction-inert solvent in the presence of a base.
Claim 17
Dependent Claim
23 words
A process according to claim 10, wherein the process is conducted at a temperature in the range from 30° C. to 200° C.
Claim 18
Dependent Claim
46 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 6 alkyl, hydroxy C 1 -C 2 alkyl, hydroxy C 4 -C 6 alkyl, carboxy C 1 -C 6 alkyl or (C 1 -C 6 alkoxy carbonyl) C 1 -C 6 alkyl.
Claim 19
Dependent Claim
46 words
A γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 6 alkyl, hydroxy C 1 -C 2 alkyl, hydroxy C 4 -C 6 alkyl, carboxy C 1 -C 6 alkyl or (C 1 -C 6 alkoxy carbonyl) C 1 -C 6 alkyl.
Claim 20
Dependent Claim
35 words
A γ-cyclodextrin ether or mixed ether according to claim 15 wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 alkyl, hydroxy C 4 alkyl, or carboxy C 1 -C 2 alkyl.
Claim 21
Dependent Claim
20 words
A γ-cyclodextrin derivative according to claim 15 wherein the either substituents are methyl, ethyl, isopropyl, hydroxyethyl, hydroxybutyl, carboxymethyl, or carboxyethyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-08-16 | 1992-02-15 | 1992-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-16 | 1996-02-15 | 1996-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-16 | 2000-02-15 | 2000-08-16 | $7700.00 | Window Closed / Lapsed |