Patent US4764603A successfully refreshed from Google Patents.
US4764603A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable salts of S-adenosyl-L-methionine with polyanions
Assignee: Gibipharma SpA
•
Filing: 1985-08-09
•
Granted: 1988-08-16
•
Expires: 2005-08-09
Abstract
Abstract Stable salts of S-adenosyl-L-methionine with water-soluble polyanions, such as polyphosphates, polyvinylsulfonates -sulfates or -phosphates, polyacrylates, polystyrene sulfonates, are described. The salts according to the invention, prepared by precipitation from aqueous solutions of pH not exceeding 3.5, possess peculiar stability, solubility, nonhygroscopicity and are valuable for use as active constituents in pharmaceutical compositions.
Inventors
- 👤 Vincenzo Zappia
- 👤 Mario De Rosa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:10
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; A; A61; A61P; A61P1/00; A61P1/16; C07D; C07D473/00; C07D473/26
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
47 words
A salt of S-adenosyl-L-methionine and a water-soluble polyanionic substance selected from the group consisting of a polyphosphate, metaphosphate, polystyrene sulfonate, polyvinyl sulfonate, polyvinyl sulfate, polyvinyl phosphate, and polyacrylate wherein the stoichiometric ratio of mols of S-adenosyl-L-methionine to gram-equivalent of the polyanionic substance is from 0.1:1 to 0.5:1.
Claim 2
Dependent Claim
47 words
A salt of S-adenosyl-L-methionine and a water-soluble polyanionic substance selected from the group consisting of a polyphosphate, metaphosphate, polystyrene sulfonate, polyvinyl sulfonate, polyvinyl sulfate, polyvinyl phosphate, and polyacrylate wherein the stoichiometric ratio of mols of S-adenosyl-L-methionine to gram-equivalent of the polyanionic substance is from 0.1:1 to 0.5:1.
Claim 3
Dependent Claim
17 words
A salt of S-adenosyl-L-methionine according to claim 1 wherein the polyanionic substance is a polyphosphate or metaphosphate.
Claim 4
Dependent Claim
16 words
A salt of S-adenosyl-L-methionine according to claim 1 wherein the polyanionic substance is a para-polystyrene sulfonate.
Claim 5
Dependent Claim
23 words
A salt of S-adenosyl-L-methionine according to claim 1 wherein the stoichiometric ratio of S-adenosyl-L-methionine to gram-equivalent of the polyanionic substance is about 0.33:1.
Claim 6
Dependent Claim
83 words
A process for the preparation of a salt of according to claim 1 which comprises the steps of (a) mixing a solution of S-adensoyl-L-methionine at acidic pH with a solution of the polyanionic substance wherein the stoichiometric ratio of S-adenosyl-L-methionine to gram-equivalent of the polyanionic substance is from 0.1:1 to 0.5:1, at the same pH while stirring at room temperature, (b) collecting the salt thus formed, (c) washing the collected salt with water, and (d) drying the salt under vacuum or by lyophilization.
Claim 7
Dependent Claim
24 words
The process according to claim 5 wherein step (a) is carried out by having S-adenosyl-L-methionine precipitated from extracts of yeast cells enriched with S-adenosyl-L-methionine.
Claim 8
Dependent Claim
41 words
The process according to claim 6 wherein prior to drying, the precipitate formed is first dissolved at pH of from 4 to 5 in an adequate volume of water and is then precipitated again by lowering the pH of the solution.
Claim 9
Dependent Claim
14 words
The process according to claim 5 wherein step (a) is conducted at 4° C.
Claim 10
Dependent Claim
32 words
The process according to claim 5 wherein, at the end of the precipitation in step (a), there is added up to 1 volume of an organic, water-miscible solvent to the aqueous phase.
Claim 11
Dependent Claim
19 words
The process according to claim 5 wherein, in step (b), the precipitate is washed by grinding in organic solvents.
Claim 12
Dependent Claim
25 words
A pharmaceutical composition comprising an effective amount of at least one salt according to claim 1 in combination with at least one compatible, nontoxic excipient.
Claim 13
Dependent Claim
26 words
A pharmaceutical composition according to claim 11 in the form of a capsule, tablet, sugar-coated pill, an ampule of intravenous or intramuscular injectable solution, or suppository.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-16 | 1992-02-15 | 1992-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-16 | 1996-02-15 | 1996-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-16 | 2000-02-15 | 2000-08-16 | $7700.00 | Window Closed / Lapsed |