Patent US4764595A successfully refreshed from Google Patents.
US4764595A
Expired / Lapsed
US
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Resin support for solid phase peptide synthesis
Assignee: Monsanto Co
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Filing: 1986-12-24
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Granted: 1988-08-16
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Expires: 2006-12-24
Abstract
Abstract A resin and method for using the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stable to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.
Inventors
- 👤 Daniel P. Getman
- 👤 Robert M. Heintz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 14:56
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/04; C07K1/042; C08; C08F; C08F8/00; C08F8/04; C08F8/34; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
53 words
A resin for solid phase peptide synthesis comprising the structure ##STR13## where P is the polymer support, R 1 is a substituted or unsubstituted aromatic, R 2 is an alkyl having from 1 to 20 carbon atoms, R 3 is substituted or unsubstituted phenyl, and n and m independently equal 0 or 1.
Claim 2
Dependent Claim
53 words
A resin for solid phase peptide synthesis comprising the structure ##STR13## where P is the polymer support, R 1 is a substituted or unsubstituted aromatic, R 2 is an alkyl having from 1 to 20 carbon atoms, R 3 is substituted or unsubstituted phenyl, and n and m independently equal 0 or 1.
Claim 3
Dependent Claim
14 words
The resin of claim 1 wherein the polymer support is a crosslinked polystyrene gel.
Claim 4
Dependent Claim
19 words
The resin of claim 1 wherein R 1 and R 2 are unsubstituted phenyls and R 2 is methylene.
Claim 5
Dependent Claim
22 words
A resin for solid phase peptide synthesis comprising a polymer support having the structure ##STR14## where P is a crosslinked polystyrene resin.
Claim 6
Dependent Claim
22 words
A resin for solid phase peptide synthesis comprising a polymer support having the structure ##STR14## where P is a crosslinked polystyrene resin.
Claim 7
Dependent Claim
37 words
A resin for solid phase peptide synthesis comprising the structure ##STR15## where R 1 is a an alkyl having from 1 to 20 carbon atoms, P is a crosslinked polystyrene resin and n equals 0 to 20.
Claim 8
Dependent Claim
37 words
A resin for solid phase peptide synthesis comprising the structure ##STR15## where R 1 is a an alkyl having from 1 to 20 carbon atoms, P is a crosslinked polystyrene resin and n equals 0 to 20.
Claim 9
Dependent Claim
15 words
The resin of claim 5 wherein R 1 is a methylene and n is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-16 | 1992-02-15 | 1992-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-16 | 1996-02-15 | 1996-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-16 | 2000-02-15 | 2000-08-16 | $7700.00 | Window Closed / Lapsed |