US4760142A
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Divalent hapten derivatives
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1987-07-06
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Granted: 1988-07-26
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Expires: 2007-07-06
Abstract
Abstract Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formula A--X--A where A is a bonded hapten moiety and X is a bifunctional spacer having the formula (B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.m where m is independently 0 or 1, B is (CH 2 ) n' , wherein n' is an integer from 1 to 4, or CO(CH 2 ) n" , wherein n" is an integer from 2 to 4; Y is independently --CONH--, NHCO--, OOC--, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom are disclosed.
Inventors
- 👤 Kathleen J. Primes
- 👤 Gerald F. Sigler
- 👤 Gerd Grenner
- 👤 Wolfgang Kapmeyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:53
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/536; G01N33/543; G01N33/54313; G01N33/74; G01N33/78; G01N33/94; Y; Y10; Y10S; Y10S436/00; Y10S436/815; Y10S436/816; Y10S436/822; Y10S436/823
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
159 words
A divalent hapten derivative comprising two hapten moieties connected by means of a bifunctional spacer having the formula A-X-A where A is a bonded hapten moiety and X is a bifunctinal spacer having the formula (B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.m where m is independently 0 or 1, B is (CH 2 ) n ', wherein n' is an integer from 1 to 4, or CO(CH 2 ) n " is an integer from 2 to 4; Y is independently --CONH--, --NHCO--, --OOC--, --COO-- --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is selected from the group consisting of -alkylene-O-alkylene-, alkylene-NH-alkylene, ##STR12## where the term alkyl means a straight or branched chain saturated hydrocarbon group having 1 to 6 carbon atoms and the term alkylene refers to a bivalent radical of the branched or unbranched alkyl group it is derived from having valence bonds from two terminal carbons thereof.
Claim 2
Dependent Claim
159 words
A divalent hapten derivative comprising two hapten moieties connected by means of a bifunctional spacer having the formula A-X-A where A is a bonded hapten moiety and X is a bifunctinal spacer having the formula (B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.m where m is independently 0 or 1, B is (CH 2 ) n ', wherein n' is an integer from 1 to 4, or CO(CH 2 ) n " is an integer from 2 to 4; Y is independently --CONH--, --NHCO--, --OOC--, --COO-- --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is selected from the group consisting of -alkylene-O-alkylene-, alkylene-NH-alkylene, ##STR12## where the term alkyl means a straight or branched chain saturated hydrocarbon group having 1 to 6 carbon atoms and the term alkylene refers to a bivalent radical of the branched or unbranched alkyl group it is derived from having valence bonds from two terminal carbons thereof.
Claim 3
Dependent Claim
24 words
The divalent hapten derivative of claim 1 wherein Z is selected from --O--(CH 2 ) 4 --O--, ##STR13## and NH(CH 2 ) 4 NH--.
Claim 4
Dependent Claim
13 words
The divalent hapten derivative of claim 1 wherein said bifunctional spacer is bis-(N-succinyl-4,9-dioxa-1,12-dodecanediamine.
Claim 5
Dependent Claim
13 words
The divalent hapten derivative of claim 1 wherein said bifunctional spacer is 4,9-dioxa-1,12-dodecanediamine.
Claim 6
Dependent Claim
13 words
The divalent hapten derivative of claim 1 wherein said bifunctional spacer is bis-(3-aminopropyl)piperazine.
Claim 7
Dependent Claim
12 words
The divalent hapten derivative of claim 1 wherein said hapten is theophylline.
Claim 8
Dependent Claim
12 words
The divalent hapten derivative of claim 1 wherein said hapten is L-thyroxine.
Claim 9
Dependent Claim
12 words
The divalent hapten derivative of claim 1 wherein said hapten is phenobarbital.
Claim 10
Dependent Claim
11 words
The divalent hapten derivative of claim 1 which comprises theophylline-8-butyric acid.
Claim 11
Dependent Claim
10 words
The divalent hapten derivative of claim 1 which comprises bis-(Theophylline-8-butyryl)-4,9-dioxa-1,12-dodecanediamide.
Claim 12
Dependent Claim
12 words
The divalent hapten derivative of claim 1 which comprises bis-(theophyllne-8-butyryl)-N,N-bis-3-aminopropyl piperazine diamide.
Claim 13
Dependent Claim
10 words
The divalent hapten derivative of claim 1 which comprises bis-(Phenobarbital-N-propionyl)-4,9-dioxa-1,12-dodecanediamide.
Claim 14
Dependent Claim
10 words
The divalent hapten derivative of claim 1 which comprises bis-(triflurooacetyl-L-thyroxyl)-4,9-dioxa-1,12-dodecanediamide.
Claim 15
Dependent Claim
12 words
The divalent hapten derivative of claim 1 which comprises bis-(L-thyroxyl)-4,9-dioxa-1,12-dodecanediamide, dihydrochloride salt.
Claim 16
Dependent Claim
10 words
The divalent hapten derivative of claim 1 which comprises bis-(N-succinyl-L-thyroxyl)-4,9-dioxa-1,12-dodecanediamide.
Claim 17
Dependent Claim
16 words
A hapten derivative for a turbidimetric hapten assay comprising the divalent hapten derivative of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-26 | 1992-01-25 | 1992-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-26 | 1996-01-25 | 1996-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-26 | 2000-01-25 | 2000-07-26 | $7700.00 | Window Closed / Lapsed |