Carbostyril compounds, compositions containing same and processes for preparing same

Claim 2

A carbostyril compound of the formula (I): ##STR56## wherein R 1 is a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkoxycarbonyl-lower alkyl group, a phenyl-lower alkyl group which has, on the phenyl ring thereof, 1 to 3 substituents selected from among lower alkanoyloxy and hydroxy groups, a benzoyl group which may optionally be substituted, on the phenyl ring thereof, withn 1 to 3 substituents selected from the group consisting of nitro, unsubstituted or lower alkyl-substituted amino, phenyl-lower alkoxy, hydroxy, carboxy, phenyl-lower alkoxycarbonyl-lower alkoxy, lower alkanoyloxy, carboxy-lower alkoxy and lower alkyl-substituted amino-lower alkyl, or a naphthoyl group, R 2 is a benzoyl group which may optionally have, on the phenyl ring thereof, 1 or 2 lower alkoxy groups, and its pharmaceutically acceptable salt.

Claim 3

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 1, wherein R 2 is a benzoyl group which is substituted with 1 or 2 of a (C 1-6 )alkoxy group.

Claim 4

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 2, wherein R 1 is a benzoyl group which may optionally be substituted, on the phenyl ring thereof, with 1 to 3 substituents selected from the group consisting of nitro, unsubstituted or (C 1-6 )alkyl-substituted amino, phenyl-(C 1-6 )alkoxy, hydroxy, carboxy, phenyl-(C 1-6 )alkoxycarbonyl-(C 1-6 )alkoxy, (C 1-6 )alkanoyloxy, carboxy-(C 1-6 )alkoxy, and (C 1-6 )alkylsubstituted amino-(C 1-6 )alkyl

Claim 5

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 2, wherein R 1 is a (C 1-6 )alkanoyl group.

Claim 6

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 2, wherein R 1 is a (C 1-6 )alkoxycarbonyl group, a (C 1-6 )alkoxycarbonyl-(C 1-6 )alkyl group, a phenyl-(C 1-6 )alkyl group which has, on the phenyl ring thereof, 1 to 3 substitutent selected from among (C 1-6 )alkanoyloxy and hydroxy groups, or a naphthoyl group.

Claim 7

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 3, wherein R 1 is a benzoyl group which is substituted, on the phenyl ring thereof, with 1 to 3 substituents selected from the group consisting of hydroxy, carboxy, unsubstituted or (C 1-6 )alkyl-substituted amino, carboxy-(C 1-6 )alkoxy, and (C 1-6 )alkyl-substituted amino-(C 1-6 )alkyl.

Claim 8

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 3, wherein R 1 is an unsubstituted benzoyl group.

Claim 9

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 6, wherein R 1 is a benzoyl group which is substituted, on the phenyl ring thereof, 1 to 2 substituents selected form the group consisting of unsubstituted or (C 1-6 )alkyl-substituted amino, hydroxy, and carboxy-(C 1-6 )alkoxy.

Claim 10

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 8, wherein R 2 is a 3,4-di(C 1-6 )alkoxybenzoyl group.

Claim 11

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 9, wherein R 1 is a benzoyl group which is substituted, on the phenyl ring thereof, with one substituent selected form the group consisting of unsubstituted or (C 1-6 )alkyl-substituted amino, and hydroxy.

Claim 12

1-(4-Aminobenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril according to claim 10.

Claim 13

1-(4-Hydroxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril according to claim 10.

Claim 14

1-Benzxoyl-6-[4-(3,4-dimethoxybenzxoyl)-1-piperazinyl]-3,4-dihydrocarbostyril according to claim 7.

Claim 15

1-(4-Hydroxy-3-dimethylaminomethylbenzxoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril according to claim 9.

Claim 16

1-(3-Hydroxy-5-carboxymethoxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril according to claim 9.

Claim 17

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 5, wherein R 1 is a (C 1 -C 6 ) alkoxycarbonyl group.

Claim 18

A carbostyril compound of the formula (I): ##STR57## wherein R 1 is a lower alkanoyl group, a lower alkoxycarbonyl group, a benzoyl group which may optionally be substituted, on the phenyl ring thereof, with 1 to 2 substituents selected from the group consisting of unsubstituted amino, hydroxy, and carboxy, R 2 is a benzoyl group which may optionally have, on the phenyl ring thereof, 1 or 2 of a lower alkoxy group, and its pharmaceutically acceptable salt.

Claim 19

A carbostyril compound of the formula (I): ##STR57## wherein R 1 is a lower alkanoyl group, a lower alkoxycarbonyl group, a benzoyl group which may optionally be substituted, on the phenyl ring thereof, with 1 to 2 substituents selected from the group consisting of unsubstituted amino, hydroxy, and carboxy, R 2 is a benzoyl group which may optionally have, on the phenyl ring thereof, 1 or 2 of a lower alkoxy group, and its pharmaceutically acceptable salt.

Claim 20

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 17, wherein R 1 is a benzoyl group which is substituted, on the phenyl ring thereof, 1 to 2 substituents selected from the group consisting of unsubstituted amino, hydroxy, and carboxy.

Claim 21

A carbostyril compound or its pharmaceutically acceptable salt as claimed in claim 18, wherein R 1 is a benzoyl group which is substituted, on the phenyl ring thereof, with one substituent selected from the group consisting of unsubstituted amino and hydroxy.

Claim 22

A cardiotonic composition comprising a cardiotonically effective amount of a compound of the formula (I): ##STR58## wherein R 1 is a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkoxycarbonyl-lower alkyl group, a phenyl-lower alkyl group which has, on the phenyl ring thereof, 1 to 3 substituents selected from among lower alkanoyloxy and hydroxy groups, a benzoyl group which may optionally be substituted, on the phenyl ring thereof, with 1 to 3 substituents selected from the group consisting of nitro, unsubstituted or lower alkyl-substituted amino, phenyl-lower alkoxy, hydroxy, carboxy, phenyl-lower alkoxycarbonyl-lower alkoxy, lower alkanoyloxy, carboxyl-lower alkoxy, and lower alkyl-substituted amino-lower alkyl, or a naphthoyl group, R 2 is a benzoyl group which may optionally have, on the phenyl ring thereof, 1 or 2 lower alkoxy groups, and its pharmaceutically acceptable salt.

Claim 23

A cardiotonic composition comprising a cardiotonically effective amount of a compound of the formula (I): ##STR58## wherein R 1 is a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkoxycarbonyl-lower alkyl group, a phenyl-lower alkyl group which has, on the phenyl ring thereof, 1 to 3 substituents selected from among lower alkanoyloxy and hydroxy groups, a benzoyl group which may optionally be substituted, on the phenyl ring thereof, with 1 to 3 substituents selected from the group consisting of nitro, unsubstituted or lower alkyl-substituted amino, phenyl-lower alkoxy, hydroxy, carboxy, phenyl-lower alkoxycarbonyl-lower alkoxy, lower alkanoyloxy, carboxyl-lower alkoxy, and lower alkyl-substituted amino-lower alkyl, or a naphthoyl group, R 2 is a benzoyl group which may optionally have, on the phenyl ring thereof, 1 or 2 lower alkoxy groups, and its pharmaceutically acceptable salt.