Patent US4757089A successfully refreshed from Google Patents.
US4757089A
Expired / Lapsed
US
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Increasing aqueous humor outflow
Assignee: Allergan Inc
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Filing: 1986-12-30
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Granted: 1988-07-12
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Expires: 2006-12-30
Abstract
Abstract A method of increasing aqueous humor outflow in the eye of a human patient including topically administering to the eye an outflow increasing amount of a compound characterized in that it contains one or more groups capable of reacting with sulfhydryl groups in the trabecular meshwork of the eye, and it has a margin of safety of at least 2.0.
Inventors
- 👤 David L. Epstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/33; A61K31/335; A61K31/365; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
79 words
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma in said patient, said method comprising topically administering to said eye an outflow increasing amount of ethacrynic acid, or an analog of ethacrynic acid which contains a chemical group capable of reacting with sulfhydryl groups in the trabecular meshwork of said eye, has a margin of safety of at least 2.0 and has an octanol: water partition coefficient of at least 0.005.
Claim 2
Independent Claim
79 words
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma in said patient, said method comprising topically administering to said eye an outflow increasing amount of ethacrynic acid, or an analog of ethacrynic acid which contains a chemical group capable of reacting with sulfhydryl groups in the trabecular meshwork of said eye, has a margin of safety of at least 2.0 and has an octanol: water partition coefficient of at least 0.005.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein said outflow increasing compound is ethacrynic acid or a pharmaceutically acceptable salt thereof.
Claim 4
Independent Claim
71 words
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma in said patient, said method comprising administering by microinjection to the trabecular meshwork of said eye an outflow increasing amount of ethacrynic acid, or an analog of ethacrynic acid which contains a chemical group capable of reacting with sulfhydryl groups in said trabecular meshwork, and has a margin of safety of at least 2.0.
Claim 5
Independent Claim
71 words
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma in said patient, said method comprising administering by microinjection to the trabecular meshwork of said eye an outflow increasing amount of ethacrynic acid, or an analog of ethacrynic acid which contains a chemical group capable of reacting with sulfhydryl groups in said trabecular meshwork, and has a margin of safety of at least 2.0.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-12 | 1992-01-11 | 1992-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-12 | 1996-01-11 | 1996-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-12 | 2000-01-11 | 2000-07-12 | $7700.00 | Window Closed / Lapsed |