Patent US4757055A successfully refreshed from Google Patents.
US4757055A
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Method for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
Assignee: Johns Hopkins University
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Filing: 1984-04-27
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Granted: 1988-07-12
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Expires: 2004-04-27
Abstract
Abstract A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
Inventors
- 👤 Paul S. Miller
- 👤 Paul O. P. Ts'o
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:21
CPC Classifications
C; C07; C07H; C07H21/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
51 words
A method for inhibiting the Herpes simplex virus (type 1 and type 2) in a host in need of such treatment which comprises binding the said virus in said host with an effective amount of a nonionic oligonucleoside alkyl or arylphosphonate which is complementary to the base sequence of said virus.
Claim 2
Independent Claim
51 words
A method for inhibiting the Herpes simplex virus (type 1 and type 2) in a host in need of such treatment which comprises binding the said virus in said host with an effective amount of a nonionic oligonucleoside alkyl or arylphosphonate which is complementary to the base sequence of said virus.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the oligonucleotide alkyl or arylphosphonate is an octamer.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein the phosphonate is an oligonucleoside methyl phosphonate.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the oligonucleoside alkylphosphonate has the formula: d-TpCpCpTpCpCpTpG where p=methylphosphonate linkages p=a phosphodiester linkage.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-12 | 1992-01-11 | 1992-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-12 | 1996-01-11 | 1996-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-12 | 2000-01-11 | 2000-07-12 | $7700.00 | Window Closed / Lapsed |