US4753635A
Expired / Lapsed
US
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Inducing analgesia by implantation of cells releasing neuroactive substances
Assignee: Microbot Medical Inc
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Filing: 1986-05-23
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Granted: 1988-06-28
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Expires: 2006-05-23
Abstract
Abstract A method of inducing analgesia or reducing pain is described. The method involves implanting in the central nervous system of a host susceptible to pain, living material capable of releasing effective amount of analgesic substance when interacted with a stimulus which induces said material to release analgesic amount of said substance. The procedure described herein reduces sensitivity to intractable pain.
Inventors
- 👤 Jacqueline Sagen
- 👤 Mark Perlow
- 👤 George D. Pappas
- 👤 Harvey B. Pollard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 03:20
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/022; A61K; A61K35/00; A61K35/12; A61K35/30
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
56 words
A method of inducing analgesia or reducing pain comprising implanting isolated, substantially homogeneously purified chromaffin cells or adrenal medullary tissue in nociceptor region of central nervous system of a host susceptible to pain, and stimulating said cells or tissue by infecting a nicotinic or muscarinic agonist to release effective amount of analgesic substance to reduce pain.
Claim 2
Independent Claim
56 words
A method of inducing analgesia or reducing pain comprising implanting isolated, substantially homogeneously purified chromaffin cells or adrenal medullary tissue in nociceptor region of central nervous system of a host susceptible to pain, and stimulating said cells or tissue by infecting a nicotinic or muscarinic agonist to release effective amount of analgesic substance to reduce pain.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein said material is isolated, substantially homogeneously purified bovine chromaffin cells.
Claim 4
Dependent Claim
16 words
The method of claim 2, wherein said nociceptor region is in spinal cord or brain stem.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein said stimulus is nicotine.
Claim 6
Dependent Claim
16 words
The method according to claim 1, of reversing the release of analgesic substance by an antagonist.
Claim 7
Dependent Claim
22 words
The method of claim 5 wherein said antagonist is selected from the group consisting of opiate antagonist, adrenergic antagonist and ganglionic antagonist.
Claim 8
Dependent Claim
10 words
The method of claim 6 wherein said antagonist is naloxone.
Claim 9
Dependent Claim
19 words
The method of claim 3, wherein the nociceptor region in the spinal cord is dorsal horn of lumbar region.
Claim 10
Dependent Claim
22 words
The method of claim 8, wherein the nociceptor region in the spinal cord is subarachnoid space of dorsal horn of lumbar region.
Claim 11
Dependent Claim
16 words
The method of claim 3, wherein the nociceptor region in the spinal cord is substantia gelatinosa.
Claim 12
Dependent Claim
29 words
The method of claim 3, wherein the nociceptor region in the brain stem is selected from the group consisting of peraqueductal gray, nucleous raphe magnus and nucleus reticularis gigantocellularis.
Claim 13
Dependent Claim
12 words
The method of claim 11, wherein the nociceptor region is periaqueductal gray.
Claim 14
Dependent Claim
13 words
The method of claim 11, wherein the nociceptor region is nucleus raphe magnus.
Claim 15
Dependent Claim
13 words
The method of claim 11, wherein the nociceptor region is nucleus reticularis giganticellularis.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-28 | 1991-12-28 | 1992-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-28 | 1995-12-28 | 1996-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-28 | 1999-12-28 | 2000-06-28 | $7700.00 | Window Closed / Lapsed |