US4751077A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Interferons with novel cysteine pattern
Assignee: GD Searle LLC
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Filing: 1984-11-30
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Granted: 1988-06-14
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Expires: 2004-11-30
Abstract
Abstract Human interferons containing novel cysteine substitutions and disulfide bonds are disclosed. The amino acid sequence of a first interferon is combined with the cysteine and/or disulfide pattern of a second interferon resulting in a molecule with hybrid properties.
Inventors
- 👤 Leslie D. Bell
- 👤 John C. Smith
- 👤 Alan G. Porter
- 👤 John R. Adair
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:49
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/555; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/142; Y10S930/26
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
23 words
A modified beta interferon comprising a beta interferon wherein the tyrosine located at position 3 of natural beta interferon is replaced with cysteine.
Claim 2
Dependent Claim
23 words
A modified beta interferon comprising a beta interferon wherein the tyrosine located at position 3 of natural beta interferon is replaced with cysteine.
Claim 3
Dependent Claim
38 words
A modified beta interferon comprising a beta interferon wherein the tyrosine located at position 3 of natural beta interferon is replaced with cysteine and the valine located at position 101 of natural beta interferon is replaced with cysteine.
Claim 4
Dependent Claim
38 words
A modified beta interferon comprising a beta interferon wherein the tyrosine located at position 3 of natural beta interferon is replaced with cysteine and the valine located at position 101 of natural beta interferon is replaced with cysteine.
Claim 5
Dependent Claim
52 words
A modified beta interferon comprising a beta interferon wherein the tyrosine located at position 3 of natural beta interferon is replaced with cysteine, the cysteine located at position 17 of natural beta inerferon is replaced with serine, and the valine located at position 101 of natural beta interferon is replaced with cysteine.
Claim 6
Dependent Claim
52 words
A modified beta interferon comprising a beta interferon wherein the tyrosine located at position 3 of natural beta interferon is replaced with cysteine, the cysteine located at position 17 of natural beta inerferon is replaced with serine, and the valine located at position 101 of natural beta interferon is replaced with cysteine.
Claim 7
Dependent Claim
33 words
A pharmaceutical composition for use in the treatment of viral infections in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 1 admixed with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
33 words
A pharmaceutical composition for use in the treatment of viral infections in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 2 admixed with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
33 words
A pharmaceutical composition for use in the treatment of viral infections in an animal comprising an effective therapeutic amount of the modified beta interferon of claim 3 admixed with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
29 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective amount of a modified beta interferon of claim 1.
Claim 11
Dependent Claim
29 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective amount of a modified beta interferon of claim 2.
Claim 12
Dependent Claim
29 words
A method of treating viral infections in an animal in need of such treatment comprising the administration of an effective amount of a modified beta interferon of claim 3.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-14 | 1991-12-14 | 1992-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-14 | 1995-12-14 | 1996-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-14 | 1999-12-14 | 2000-06-14 | $7700.00 | Window Closed / Lapsed |