US4746652A
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US
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Method of inducing diuresis with lysophospholipids
Assignee: Wake Forest Baptist Medical Center
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Filing: 1986-11-18
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Granted: 1988-05-24
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Expires: 2006-11-18
Abstract
Abstract Lysophospholipids are used to induce diuresis in a subject by administering them in a dose effective to increase the renal excretion of sodium. Exemplary compounds useful in this method include steroyl-lysophosphatidylcholine and steroyl-lysophosphatidylethanolamine.
Inventors
- 👤 Vardaman M. Buckalew, Jr.
- 👤 Albert L. Rauch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 00:57
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/683; A61K31/685
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
118 words
A method of inducing diuresis in a human or animal subject in need of said treatment comprising administering to the subject in an amount effective to increase the subject's renal excretion of sodium, a compound or a pharmaceutically acceptable salt thereof, said compound being of the formula ##STR2## wherein R 1 is an alkyl group having from 12 to 24 carbon atoms, or an alkenyl group having from 12 to 24 carbon atoms with not more than four carbon-carbon double bonds, and wherein R 3 is selected from the class consisting of --CH 2 CH 2 N + (CH 3 ) 3 , --CH 2 CH 2 NH 3 + , and --CH 2 CHNH 3 + COO--.
Claim 2
Independent Claim
118 words
A method of inducing diuresis in a human or animal subject in need of said treatment comprising administering to the subject in an amount effective to increase the subject's renal excretion of sodium, a compound or a pharmaceutically acceptable salt thereof, said compound being of the formula ##STR2## wherein R 1 is an alkyl group having from 12 to 24 carbon atoms, or an alkenyl group having from 12 to 24 carbon atoms with not more than four carbon-carbon double bonds, and wherein R 3 is selected from the class consisting of --CH 2 CH 2 N + (CH 3 ) 3 , --CH 2 CH 2 NH 3 + , and --CH 2 CHNH 3 + COO--.
Claim 3
Dependent Claim
14 words
A method according to claim 1, wherein said compound is administered by intravenous injection.
Claim 4
Dependent Claim
28 words
A method according to claim 1, wherein said compound is administered in an amount of from about 1.0 picomole to about 10 nanomole per kilogram of subject weight.
Claim 5
Dependent Claim
35 words
A method according to claim 1, wherein R 3 is selected from the group consisting of --CH 2 CH 2 N + (CH 3 ) 3 and --CH 2 CH 2 NH 3 + .
Claim 6
Dependent Claim
22 words
A method according to claim 1, wherein R 1 is a long chain alkyl group having from 14 to 20 carbon atoms.
Claim 7
Dependent Claim
24 words
A method according to claim 1, wherein said compound is administered to said subject at intervals of not less than two hours between administration.
Claim 8
Independent Claim
104 words
A method of inducing diuresis in a human or animal subject in need of said treatment, comprising administering to the subject in an amount effective to increase the subject's renal excretion of sodium at intervals of not less than two hours between administration a compound or a pharmaceutically acceptable salt thereof, said compound being of the formula: ##STR3## wherein R 1 is a long chain alkyl group having from 14 to 20 carbon atoms, and wherein R 3 is selected from the class consisting of CH 2 CH 2 N + (CH 3 ) 3 and --CH 2 CH 2 NH 3 + .
Claim 9
Independent Claim
104 words
A method of inducing diuresis in a human or animal subject in need of said treatment, comprising administering to the subject in an amount effective to increase the subject's renal excretion of sodium at intervals of not less than two hours between administration a compound or a pharmaceutically acceptable salt thereof, said compound being of the formula: ##STR3## wherein R 1 is a long chain alkyl group having from 14 to 20 carbon atoms, and wherein R 3 is selected from the class consisting of CH 2 CH 2 N + (CH 3 ) 3 and --CH 2 CH 2 NH 3 + .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-24 | 1991-11-23 | 1992-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-24 | 1995-11-23 | 1996-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-24 | 1999-11-23 | 2000-05-24 | $7700.00 | Window Closed / Lapsed |