US4552869A
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O-Alkyl-O-carbamoylglycerophosphocholines and the use for treating hypertension
Assignee: A Natterman und Cie GmbH
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Filing: 1984-06-15
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Granted: 1985-11-12
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Expires: 2004-06-15
Abstract
Abstract The present invention relates to new O-alkyl-O-carbamoylglycerophosphocholines of the general formulae I or II ##STR1## and processes for treating human beings suffering from diseases caused by hypertension by administering one or several of the above compounds.
Inventors
- 👤 Hans-Heiner Lautenschlager
- 👤 Hans Betzing
- 👤 Gerrit Prop
- 👤 Ottfried Zierenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:17
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
72 words
O-Alkyl-O-carbamoylglycerophosphocholines of the general formulae I or II ##STR8## wherein R 1 denotes a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, and R 2 and R 3 can be identical or different and denote a straight-chain or branched, saturated or unsaturated hydrocarbon radical having 1-20 C atoms, or a hydrogen atom, provided that at least one of R 2 and R 3 is a hydrocarbon radical as defined herein.
Claim 2
Dependent Claim
72 words
O-Alkyl-O-carbamoylglycerophosphocholines of the general formulae I or II ##STR8## wherein R 1 denotes a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, and R 2 and R 3 can be identical or different and denote a straight-chain or branched, saturated or unsaturated hydrocarbon radical having 1-20 C atoms, or a hydrogen atom, provided that at least one of R 2 and R 3 is a hydrocarbon radical as defined herein.
Claim 3
Dependent Claim
39 words
1-O-Alkyl-2-O-carbamoylglycero-3-phosphocholines of the general formula I wherein R 1 denotes a straight-chain, saturated hydrocarbon radical having 10-20 C atoms, R 2 denotes a hydrogen atom and R 3 denotes a straight-chain or branched hydrocarbon radical having 1-9 C atoms.
Claim 4
Dependent Claim
39 words
1-O-Alkyl-2-O-carbamoylglycero-3-phosphocholines of the general formula I wherein R 1 denotes a straight-chain, saturated hydrocarbon radical having 10-20 C atoms, R 2 denotes a hydrogen atom and R 3 denotes a straight-chain or branched hydrocarbon radical having 1-9 C atoms.
Claim 5
Dependent Claim
40 words
1-O-Alkyl-2-O-carbamoylglycero-3-phosphocholines according to claim 2, characterised in that R 1 is a straight-chain, saturated hydrocarbon radical having 16, 18 or 20 C atoms while R 2 denotes a hydrogen atom and R 3 denotes a methyl, ethyl or isopropyl radical.
Claim 6
Dependent Claim
66 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines of the general formula II wherein R 1 is a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, while R 2 and R 3 can be identical or different and denote a straight-chain or branched hydrocarbon radical having 1-6 C atoms, or a hydrogen atom, provided that at least one of R 2 and R 3 is a hydrocarbon radical as defined herein.
Claim 7
Dependent Claim
66 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines of the general formula II wherein R 1 is a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, while R 2 and R 3 can be identical or different and denote a straight-chain or branched hydrocarbon radical having 1-6 C atoms, or a hydrogen atom, provided that at least one of R 2 and R 3 is a hydrocarbon radical as defined herein.
Claim 8
Dependent Claim
50 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines according to claim 4, characterised in that R 1 is a straight-chain, saturated hydrocarbon radical having 16, 18 or 20 C atoms, while R 2 and R 3 can be identical or different and denote a straight-chain or branched hydrocarbon radical having 1-3 C atoms, or a hydrogen atom.
Claim 9
Dependent Claim
56 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines according to claim 4, characterised in that R 1 is a straight-chain hydrocarbon radical which has monoolefinic or diolefinic unsaturation and has 16, 18 or 20 C atoms, while R 2 and R 3 can be identical or different and denote a straight-chain or branched hydrocarbon radical having 1-3 C atoms, or a hydrogen atom.
Claim 10
Dependent Claim
52 words
1-O-Alkyl-2-O-carbamoylglycero-3-phosphocholines of the general formula I wherein R 1 denotes a straight-chain, saturated hydrocarbon radical having 10-20 C atoms, R 2 denotes a hydrogen atom and R 3 denotes a straight-chain, saturated hydrocarbon radical having 10-20 C atoms, it being possible for R 1 and R 3 to be identical or different.
Claim 11
Dependent Claim
52 words
1-O-Alkyl-2-O-carbamoylglycero-3-phosphocholines of the general formula I wherein R 1 denotes a straight-chain, saturated hydrocarbon radical having 10-20 C atoms, R 2 denotes a hydrogen atom and R 3 denotes a straight-chain, saturated hydrocarbon radical having 10-20 C atoms, it being possible for R 1 and R 3 to be identical or different.
Claim 12
Dependent Claim
39 words
1-O-Alkyl-2-O-carbamoylglycero-3-phosphocholines according to claim 7, characterised in that R 1 and R 3 denote a straight-chain, saturated hydrocarbon radical having 16 or 18 C atoms, it being possible for R 1 and R 3 to be identical or different.
Claim 13
Dependent Claim
56 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines of the general formula II wherein R 1 is a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, R 2 denotes a hydrogen atom and R 3 denotes a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, it being possible for R 1 and R 3 to be identical or different.
Claim 14
Dependent Claim
56 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines of the general formula II wherein R 1 is a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, R 2 denotes a hydrogen atom and R 3 denotes a straight-chain, saturated or unsaturated hydrocarbon radical having 10-20 C atoms, it being possible for R 1 and R 3 to be identical or different.
Claim 15
Dependent Claim
41 words
1-O-Alkyl-3-O-carbamoylglycero-2-phosphocholines according to claim 9, characterised in that R 1 and R 3 denote a straight-chain, saturated or unsaturated hydrocarbon radical having 16 or 18 C atoms, it being possible for R 1 and R 3 to be identical or different.
Claim 16
Dependent Claim
29 words
Process for the treatment of human beings suffering from hypertension wherein a compound according to one of claims 1 to 10 are administered to the human beings so suffering.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-11 | 1989-05-13 | 1989-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-11 | 1993-05-13 | 1993-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-11 | 1997-05-13 | 1997-11-12 | $7700.00 | Window Closed / Lapsed |