US4746515A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Skin permeation enhancer compositions using glycerol monolaurate
Assignee: Alza Corp
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Filing: 1987-02-26
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Granted: 1988-05-24
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Expires: 2007-02-26
Abstract
Abstract A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with glycerol monolaurate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monolaurate employ matrix containing drug at a concentration above saturation.
Inventors
- 👤 Yu-Ling Cheng
- 👤 Diane E. Nedberge
- 👤 Edna Sugihara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:24
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
52 words
A composition of matter for application to a body surface or membrane to deliver a biologically active agent by permeation through a body surface or membrane comprising, in combination: a biologically active agent and a permeation enhancing amount of glycerol monolaurate whereas said agent and glycerol monolaurate are dispersed within a carrier.
Claim 2
Dependent Claim
52 words
A composition of matter for application to a body surface or membrane to deliver a biologically active agent by permeation through a body surface or membrane comprising, in combination: a biologically active agent and a permeation enhancing amount of glycerol monolaurate whereas said agent and glycerol monolaurate are dispersed within a carrier.
Claim 3
Dependent Claim
22 words
The composition of claim 1 wherein said agent is present in an amount in excess of its saturation concentration in the carrier.
Claim 4
Dependent Claim
14 words
The composition of claim 1 wherein said body surface or membrane is intact skin.
Claim 5
Dependent Claim
62 words
A transdermal therapeutic system comprising a combination of matter for application to a body surface or membrane comprising a biologically active agent and a permeation enhancing amount of glycerol monolaurate, in combination with: (a) an occlusive backing behind the skin distal surface of said composition, and (b) means for maintaining said composition in agent and glycerol monolaurate transferring relationship to intact skin.
Claim 6
Dependent Claim
62 words
A transdermal therapeutic system comprising a combination of matter for application to a body surface or membrane comprising a biologically active agent and a permeation enhancing amount of glycerol monolaurate, in combination with: (a) an occlusive backing behind the skin distal surface of said composition, and (b) means for maintaining said composition in agent and glycerol monolaurate transferring relationship to intact skin.
Claim 7
Independent Claim
56 words
A method for enhancing the flux of a biologically active agent through a body surface or membrane which comprises placing a source of said agent in agent transmitting relationship to said surface or membrane in the presence of a permeation enhancing amount of glycerol monolaurate wherein said agent and glycerol monolaurate are dispersed within a carrier.
Claim 8
Independent Claim
56 words
A method for enhancing the flux of a biologically active agent through a body surface or membrane which comprises placing a source of said agent in agent transmitting relationship to said surface or membrane in the presence of a permeation enhancing amount of glycerol monolaurate wherein said agent and glycerol monolaurate are dispersed within a carrier.
Claim 9
Dependent Claim
22 words
The method of claim 5 wherein the source of said agent contains agent in excess of its saturation concentration in said source.
Claim 10
Dependent Claim
14 words
The method of claim 5 wherein said body surface or membrane is intact skin.
Claim 11
Dependent Claim
83 words
In a method for administering a biologically active agent by permeation through an intact body surface which comprises: (a) placing a source of said agent and a permeation enhancer therefor in agent and permeation enhancer transmitting relationship to said body surface, and (b) maintaining said source in contact with said body surface for a period of time sufficient to produce a beneficial effect; the improvements wherein said permeation enhancer is glycerol monolaurate wherein said agent and permeation enhancer are dispersed within a carrier.
Claim 12
Dependent Claim
83 words
In a method for administering a biologically active agent by permeation through an intact body surface which comprises: (a) placing a source of said agent and a permeation enhancer therefor in agent and permeation enhancer transmitting relationship to said body surface, and (b) maintaining said source in contact with said body surface for a period of time sufficient to produce a beneficial effect; the improvements wherein said permeation enhancer is glycerol monolaurate wherein said agent and permeation enhancer are dispersed within a carrier.
Claim 13
Dependent Claim
12 words
The method of claim 8 wherein said body surface is the skin.
Claim 14
Dependent Claim
52 words
In a transdermal therapeutic system comprising; (a) a source of a transdermally deliverable biologically active agent, (b) a source of skin permeation enhancer for said agent and (c) means for maintaining said system in agent and permeation enhancer transferring relationship to intact skin; the improvement wherein said permeation enhancer is glycerol monolaurate.
Claim 15
Dependent Claim
52 words
In a transdermal therapeutic system comprising; (a) a source of a transdermally deliverable biologically active agent, (b) a source of skin permeation enhancer for said agent and (c) means for maintaining said system in agent and permeation enhancer transferring relationship to intact skin; the improvement wherein said permeation enhancer is glycerol monolaurate.
Claim 16
Dependent Claim
18 words
The system of claim 10 wherein said agent is present in said source at a concentration above saturation.
Claim 17
Dependent Claim
46 words
The system of claim 10 wherein said agent is present at a concentration sufficient to maintain the concentration above saturation for an extended period of time and said glycerol monolaurate is present at a concentration sufficient to provide permeation enhancement throughout said extended period of time.
Claim 18
Dependent Claim
52 words
A composition of matter for application to a body surface or membrane to deliver a biologically active agent by permeation through a body surface or membrane comprising, in combination: progesterone as said agent and a permeation enhancing amount of glycerol monolaurate wherein said agent and glycerol monolaurate are dispersed within a carrier.
Claim 19
Dependent Claim
52 words
A composition of matter for application to a body surface or membrane to deliver a biologically active agent by permeation through a body surface or membrane comprising, in combination: progesterone as said agent and a permeation enhancing amount of glycerol monolaurate wherein said agent and glycerol monolaurate are dispersed within a carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-24 | 1991-11-23 | 1992-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-24 | 1995-11-23 | 1996-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-24 | 1999-11-23 | 2000-05-24 | $7700.00 | Window Closed / Lapsed |