Transdermal medicament

Claim 2

A transdermal medicament comprising 10 to 20% of a transdermally active ingredient selected from the group consisting of antianginal agents, antiemetic agents, anticholinergic agents, non-steroid anti-inflammatory agents, steroid anti-inflammatory agents, antihypertensive agents, beta-blockers, vasodilators, neuroleptic agents, tranquillizers, bronchodilators, antispasmodic agents and hormones and 10 to 20% of a non-ionic emulsifying agent selected from the group consisting of polycondensates of ethylene oxide with a fatty acid or fatty alcohol, sorbitan esters, triglycerides with free hydroxyl group, polypropylene glycol monoglycerides and polyglycerol esters, the said active ingredient being dispersed in crystalline or solubilized form in a non-crosslinked, film-forming homogeneous, thermoplastic, elastomeric, water-insoluble polymer selected from the group consisting of polyurethanes based on a polyether or polyester, polyamides, polyesters, polyethers, and polyolefins, the said percentages being by weight based on the said film-forming polymer.

Claim 3

A transdermal medicament comprising 5 to 20% of a transdermally active ingredient selected from the group consisting of antianginal agents, antiemetic agents, anticholinergic agents, non-steroid anti-inflammatory agents, steroid anti-inflammatory agents, antihypertensive agents, beta-blockers, vasodilators, neuroleptic agents, tranquillizers, bronchodilators, antispasmodic agents and hormones, 5 to 30% of a non-ionic emulisfying agent selected from the group consisting of polycondensates of ethylene oxide with a fatty acid or fatty alcohol, sorbitan esters, triglycerides with free hydroxyl groups, polypropylene glycol monoglycerides and polyglycerol esters, and 1 to 30% of a copolymer containing a hydrophobic sequence which migrates to the surface of the said medicament to form a homogeneous membrane which provides complementary control of the release of the transdermally active ingredient, the said active ingredient being dispersed in crystalline or solubilized form in a non-crosslinked, film-forming homogeneous, thermoplastic, elastomeric, water-insoluble polymer selected from the group consisting of polyurthanes based on a polyether or polyester, polyamides, polyesters, polyethers, and polyolefines, the said percentages being by weight based on the said film-forming polymer.

Claim 4

A transdermal medicament comprising 5 to 20% of a transdermally active ingredient selected from the group consisting of antianginal agents, antiemetic agents, anticholinergic agents, non-steroid anti-inflammatory agents, steroid anti-inflammatory agents, antihypertensive agents, beta-blockers, vasodilators, neuroleptic agents, tranquillizers, bronchodilators, antispasmodic agents and hormones, 5 to 30% of a non-ionic emulisfying agent selected from the group consisting of polycondensates of ethylene oxide with a fatty acid or fatty alcohol, sorbitan esters, triglycerides with free hydroxyl groups, polypropylene glycol monoglycerides and polyglycerol esters, and 1 to 30% of a copolymer containing a hydrophobic sequence which migrates to the surface of the said medicament to form a homogeneous membrane which provides complementary control of the release of the transdermally active ingredient, the said active ingredient being dispersed in crystalline or solubilized form in a non-crosslinked, film-forming homogeneous, thermoplastic, elastomeric, water-insoluble polymer selected from the group consisting of polyurthanes based on a polyether or polyester, polyamides, polyesters, polyethers, and polyolefines, the said percentages being by weight based on the said film-forming polymer.

Claim 5

A medicament according to claim 1 in which the homogeneous thermoplastic polymer is a polyurethane/polyoxyethylene glcyol/polyoxypropylene glycol copolymer or a polyurethane based on polytetramethylene glycol, polycaprolactone or polyadipate.

Claim 6

A medicament according to claim 1, in which the non-ionic emulsifier is polyglycerol palmitostearate, polyglycerol isostearate, sucrose monopalmitate, polyoxymethylene oleyl glyceride, diethylene glycol monoethyl ether, or a polyoxymethyleneated C 8 -C 10 -glyceride.

Claim 7

A medicament according to clalim 2, in which the said hydrophobic copolymer is a polydimethylsiloxane polyoxyethylene glycol copolymer.

Claim 8

A medicament according to clalim 2, in which the said hydrophobic copolymer is a polydimethylsiloxane polyoxyethylene glycol copolymer.

Claim 9

A medicament according to claim 1, which is covered by an adhesive.

Claim 10

A medicament according to claim 1, in which the transdermally active ingredient is isosorbide dinitrate, isosorbide monoitrate, trinitrin, metopimazine, dimenhydrinate, scopolamine, ketoprofen, prednisolone, dexamethazone, clonidine, acebutolol, nicergoline, a neuroleptic phenothiazine, a tranquilling benzodiazepine, suriclone, suproclone, phenylpropanolamine, butylhyoscine bromide, or estradiol.

Claim 11

A transdermal medicament according to claim 1 packaged in a unit dose.

Claim 12

Method of administering a medicament to a patient which comprises applying to the skin of the said patient a transdermal medicament as claimed in claim 1 whereby an effective amount of the transdermally active ingredient in the said medicament is absorbed by the said patient.

Claim 13

A medicament according to claim 1 in which the active ingredient is isosorbide dinitrate, the non-ionic emulsifier is polyglycerol palmitostearate, and the thermoplastic elastomeric polymer is a polyurethane/polyoxyethylene glycol/polyoxypropylene glycol copolymer.

Claim 14

A medicament according to claim 2 in which the homogeneous thermoplastic polymer is a polyurethane/polyoxyethylene glycol/polyoxypropylene glycol copolymer, or a polyurethane based on polytetramethylene glycol, polycaprolactone or polyadipate.

Claim 15

A medicament according to claim 2, in which the non-ionic emulsifier is polyglycerol palmitostearate, plyglycerol isostearate, sucrose monopalmitate, polyoxymethylene oleyl glyceride, diethylene glycol monoethyl ether or a C 8 -C 10 -glyceride.

Claim 16

A medicament according to claim 2, which is covered by an adhesive.

Claim 17

A medicament according to claim 2, in which the transdermally active ingredient is isosorbide dinitrate, isosorbide monoitrate, trinitrin, metopimazine, dimenhydrinate, scopolamine, ketoprofen, predinsolone, dexamethazone, clonidine acebutolol, nicergoline, a neuroleptic phenothiazine, a tranquillising benzodiazepine, suriclone, suproclone, phenylpropanolamine, butylhyoscine bromide, or estradiol.

Claim 18

A transdermal medicament according to claim 2 packaged in a unit does.

Claim 19

A medicament according to claim 2 in which the active ingredient is isosorbide dinitrate, the non-ionic emulsifier is polyglycerol palmitostearate, and the thermoplastic elastomeric polymer is a polyurethane/polyoxyethylene glycol/polyoxypropylene glycol copolymer.

Claim 20

Method of administering a medicament to a patient which comprises applying to the skin of the said patient a transdermal medicament as claimed in claim 2 whereby an effective amount of the transdermally active ingredient in the said medicament is absorbed by the said patient.

Claim 21

A transdermal medicament according to claim 2 in which the transdermally active ingredient is isosorbide dinitrate, the non-ionic emulsifier is polyglycerol palmitostearate, the hydrophobic copolymer is polydimethylsiloxane/polyoxyethylene glycol copolymer, and the thermoplastic elastomeric polymer is a polyurethane/polyoxyethylene glycol/polyoxypropylene glycol copolymer.