Patent US4744988A successfully refreshed from Google Patents.
US4744988A
Expired / Lapsed
US
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Soft gelatin capsules and methods for their production
Assignee: Catalent Pharma Solutions Inc
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Filing: 1986-12-17
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Granted: 1988-05-17
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Expires: 2006-12-17
Abstract
Abstract A soft gelatin capsule comprising a shell of gelatin and a softener, and a filling consisting of a polyethylene glycol and a low polyhydric alcohol and at least one active substance, characterized in that (a) the dried shell of the capsule contains 4 to 40% by weight of sorbital or sorbitanes; (b) at least 50% by weight of the polyethylene glycol used in the filling for dissolving or suspending the active substance is a polyethylene glycol having a mean molecular weight of 600; and (c) the capsule filling comprises up to 20% by weight of glycerol and/or 1,2-propylene glycol.
Inventors
- 👤 Werner Brox
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4841; A61K9/4858; A61K9/4816; A61K9/4825; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
105 words
A soft gelatin capsule comprising a shell of gelatin and a softener, and a filling consisting of a polyethylene glycol and a low polyhydric alcohol and at least one active substance, characterized in that (a) the dried shell of the capsule contains 4 to 40% by weight of a mixture of sorbitol and at least one sorbitane, (b) at least 50% by weight of the polyethylene glycol used in the filling for dissolving or suspending the active substance is a polyethylene glycol having a mean molecular weight of 600, and (c) the capsule filling comprises up to 20% by weight of glycerol and/or 1,2-propylene glycol.
Claim 2
Dependent Claim
105 words
A soft gelatin capsule comprising a shell of gelatin and a softener, and a filling consisting of a polyethylene glycol and a low polyhydric alcohol and at least one active substance, characterized in that (a) the dried shell of the capsule contains 4 to 40% by weight of a mixture of sorbitol and at least one sorbitane, (b) at least 50% by weight of the polyethylene glycol used in the filling for dissolving or suspending the active substance is a polyethylene glycol having a mean molecular weight of 600, and (c) the capsule filling comprises up to 20% by weight of glycerol and/or 1,2-propylene glycol.
Claim 3
Dependent Claim
29 words
A soft gelatin capsule in accordance with claim 1, characterized in that the capsule filling of the dried capsule contains additionally between 4 and 20% by weight of water.
Claim 4
Dependent Claim
31 words
A soft gelatin capsule in accordance with claim 1, characterized in that the polyethylene glycol of the capsule filling consists exclusively of polyethylene glycol having a mean molecular weight of 600.
Claim 5
Dependent Claim
60 words
A soft gelatin capsule in accordance with claim 1, characterized in that the polyethylene glycol used in the capsule filling, a portion of at least 80% by weight is a polyethylene glycol having a mean molecular weight of 600 and a portion of up to 20% by weight is a polyethylene glycol having a mean molecular weight of above 600.
Claim 6
Dependent Claim
103 words
A method for producing a soft gelatin capsule in accordance with claim 1, characterized by the steps of conventionally enclosing a capsule filling made up of an active substance, a polyethylene glycol containing at least 50% by weight of a polyethylene glycol having a mean molecular weight of 600 and up to 20% by weight of glycerol and/or 1,2-propylene glycol, in an aqueous gelatin shell containing a mixture of sorbitol and at least one sorbitane and drying the capsule so obtained so that the dried capsule shell contains 4 to 40% by weight of the mixture of sorbitol and at least one sorbitane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |