US4743249A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dermal and transdermal patches having a discontinuous pattern adhesive layer
Assignee: Novartis Corp
•
Filing: 1987-06-10
•
Granted: 1988-05-10
•
Expires: 2007-06-10
Abstract
Abstract Dermal and transdermal patches having a discontinuous pattern printed adhesive layer on a first surface of an active-agent porous membrane, a non-porous backing layer in contact with a second surface of said porous membrane, opposite said first surface so as to define a compartment capable of containing an active agent or formulation thereof therein, an active-agent or formulation thereof within said compartment, and a protective overlayer on said adhesive layer distal to said porous membrane.
Inventors
- 👤 Frederic D. Loveland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 04:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
158 words
In a dermal or transdermal drug delivery system comprising a drug occlusive backing layer, a drug reservoir thereon and a first adhesive to affix (1) said drug reservoir and occlusive backing layer to (2) a patient such that drug contained in said reservoir can be delivered by said system to said patient, and a removable drug occlusive layer on said adhesive, the improvement comprising said first adhesive being in a discrete, discontinuous pattern in a region which, when said patch is applied to said patient, constitutes a reservoir-patient contact area, said first adhesive being present in said region to a degree which results in at least 10% of said region to no more than about 60% of said region having said first adhesive thereon, such that at least 20% of the entire surface area which will contact said patient once said patch is applied to said patient has an adhesive thereon; said drug being insoluable in said adhesive.
Claim 2
Dependent Claim
158 words
In a dermal or transdermal drug delivery system comprising a drug occlusive backing layer, a drug reservoir thereon and a first adhesive to affix (1) said drug reservoir and occlusive backing layer to (2) a patient such that drug contained in said reservoir can be delivered by said system to said patient, and a removable drug occlusive layer on said adhesive, the improvement comprising said first adhesive being in a discrete, discontinuous pattern in a region which, when said patch is applied to said patient, constitutes a reservoir-patient contact area, said first adhesive being present in said region to a degree which results in at least 10% of said region to no more than about 60% of said region having said first adhesive thereon, such that at least 20% of the entire surface area which will contact said patient once said patch is applied to said patient has an adhesive thereon; said drug being insoluable in said adhesive.
Claim 3
Dependent Claim
30 words
The improvement of claim 1 wherein said reservoir-patient contact area having said first adhesive thereon has a continuous border around the perimeter of said first adhesive of a second adhesive.
Claim 4
Dependent Claim
15 words
The improvement of claim 2 wherein said second adhesive is different than said first adhesive.
Claim 5
Dependent Claim
20 words
The improvement of claim 3 wherein said second adhesive is selected from those in which said drug is readily soluble.
Claim 6
Dependent Claim
19 words
The improvement of claim 3 wherein said second adhesive is selected from those in which said drug is insoluble.
Claim 7
Dependent Claim
16 words
The improvement of claim 2 wherein said first adhesive and said second adhesive are the same.
Claim 8
Dependent Claim
20 words
The improvement of claim 1 wherein at least 20% to about 60% of said region has said first adhesive thereon.
Claim 9
Dependent Claim
21 words
The improvement of claim 1 wherein at least about 40% to about 60% of said region has said first adhesive thereon.
Claim 10
Dependent Claim
16 words
The improvement of claim 1 wherein about 40% of said region has said first adhesive thereon.
Claim 11
Dependent Claim
14 words
The improvement of claim 1 wherein said discontinuous pattern is a series of dots.
Claim 12
Dependent Claim
16 words
The improvement of claim 1 wherein said reservoir is a matrix having said drug dispersed therein.
Claim 13
Dependent Claim
37 words
The improvement of claim 1 wherein said reservoir is a volume defined by said backing layer and a drug permeable porous membrane fused thereto along the periphery thereof, said drug being contained within said volume so defined.
Claim 14
Dependent Claim
55 words
The improved of claim 1 wherein said reservoir is a volume defined by a drug-permeable porous membrane and a secondary membrane, said reservoir being oriented such that when said patch is applied to said patient, said porous membrane is closer to said patient than said secondary membrane, said drug being within said volume so defined.
Claim 15
Dependent Claim
14 words
The improvement of claim 1 wherein said discontinuous pattern is a series of crosses.
Claim 16
Dependent Claim
158 words
In a dermal or transdermal drug delivery system comprising a drug occlusive backing layer, a drug reservoir thereon and a first adhesive to affix (1) said drug reservoir and occlusive backing layer to (2) a patient such that drug contained in said reservoir can be delivered by said system to said patient, and a removable drug occlusive layer on said adhesive, the improvement comprising said first adhesive being in a discrete, discontinuous pattern in a region which, when said patch is applied to said patient, constitutes a reservoir-patient contact area, said first adhesive being present in said region to a degree which results in at least 10% of said region to no more than about 60% of said region having said first adhesive thereon, such that at least 20% of the entire surface area which will contact said patient once said patch is applied to said patient has an adhesive thereon; said drug being soluable in said adhesive.
Claim 17
Dependent Claim
158 words
In a dermal or transdermal drug delivery system comprising a drug occlusive backing layer, a drug reservoir thereon and a first adhesive to affix (1) said drug reservoir and occlusive backing layer to (2) a patient such that drug contained in said reservoir can be delivered by said system to said patient, and a removable drug occlusive layer on said adhesive, the improvement comprising said first adhesive being in a discrete, discontinuous pattern in a region which, when said patch is applied to said patient, constitutes a reservoir-patient contact area, said first adhesive being present in said region to a degree which results in at least 10% of said region to no more than about 60% of said region having said first adhesive thereon, such that at least 20% of the entire surface area which will contact said patient once said patch is applied to said patient has an adhesive thereon; said drug being soluable in said adhesive.
Claim 18
Dependent Claim
30 words
The improvement of claim 15 wherein said reservoir-patient contact area having said first adhesive thereon has a continuous border around the perimeter of said first adhesive of a second adhesive.
Claim 19
Dependent Claim
16 words
The improvement of claim 16 wherein said first adhesive and said second adhesive are the same.
Claim 20
Dependent Claim
20 words
The improvement of claim 15 wherein at least 20% to about 60% of said region has said first adhesive thereon.
Claim 21
Dependent Claim
21 words
The improvement of claim 15 wherein at least about 40% to about 60% of said region has said first adhesive thereon.
Claim 22
Dependent Claim
16 words
The improvement of claim 15 wherein about 40% of said region has said first adhesive thereon.
Claim 23
Dependent Claim
19 words
The improvement of claim 16 wherein said second adhesive is selected from those in which said drug is insoluble.
Claim 24
Dependent Claim
14 words
The improvement of claim 15 wherein said discontinuous pattern is a series of dots.
Claim 25
Dependent Claim
16 words
The improvement of claim 15 wherein said reservoir is a matrix having said drug dispersed therein.
Claim 26
Dependent Claim
37 words
The improvement of claim 15 wherein said reservoir is a volume defined by said backing layer and a drug permeable porous membrane fused thereto along the periphery thereof, said drug being contained within said volume so defined.
Claim 27
Dependent Claim
55 words
The improved of claim 15 wherein said reservoir is a volume defined by a drug-permeable porous membrane and a secondary membrane, said reservoir being oriented such that when said patch is applied to said patient, said porous membrane is closer to said patient than said secondary membrane, said drug being within said volume so defined.
Claim 28
Dependent Claim
15 words
The improvement of claim 15 wherein said second adhesive is different than said first adhesive.
Claim 29
Dependent Claim
20 words
The improvement of claim 15 wherein said second adhesive is selected from those in which said drug is readily soluble.
Claim 30
Dependent Claim
14 words
the improvement of claim 15 wherein said discontinuous pattern is a series of crosses.
References Cited (Backward Citations)
US2399545A
Cited
US3598123A
Cited
US3598122A
Cited
US3734097A
Cited
US3797494A
Cited
US3598122B1
Cited
US3731683A
Cited
US3742951B1
Cited
US3742951A
Cited
US3996934A
Cited
US3811438A
Cited
US3870041A
Cited
US4219019A
Cited
US4402696A
Cited
US4297995A
Cited
US4341208A
Cited
US4699792A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-10 | 1991-11-09 | 1992-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-10 | 1995-11-09 | 1996-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-10 | 1999-11-09 | 2000-05-10 | $7700.00 | Window Closed / Lapsed |