Patent US601770A successfully refreshed from Google Patents.
Patent US4740903A successfully refreshed from Google Patents.
US4740903A
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Data processing system for chromatography
Assignee: Sumitomo Chemical Co Ltd
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Filing: 1985-05-14
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Granted: 1988-04-26
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Expires: 2005-05-14
Abstract
Abstract A system for processing chromatographic data which comprises an input for data representative of two chromatograms x and y, a memory for storing the inputted data of the chromatograms, and a computer operative to read out, from the memory, retention times x i and y i (i=1, . . . , n; n≧2) of at least two principal peaks of the chromatograms, respectively, and derive one function for converting the retention times x i to y i using the chromatogram y as the reference chromatogram, which gives a minimum estimated error. The computer is further operative to calculate, on the basis of the derived function, the modified retention time x' j of all the peaks of the chromatogram x. Therefore, the system permits to eliminate errors orginated from the judgment of a skilled person and to indentify and quantitatively analyze chromatogram obtained precisely without skill.
Inventors
- 👤 Kiyoharu Nakatsuka
- 👤 Shinei Ikeou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:34
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/90; G06; G06F; G06F18/00; G01N30/95; G01N30/02; G01N30/62; G01N2030/626; G01N30/86; G01N30/8624; G01N30/8631; G01N30/8665; G01N30/8668; G06F2218/00; G06F2218/12; G06F2218/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
263 words
A data processing system used in combination with a chromatography apparatus and adapted to modify one of at least two chromatograms x and y so that these chromatograms x and y can be compared with each other on the same time axis, comprising: memory means for storing data representative of said at least two chromatograms x and y; computer means coupled to the memory means; setting means coupled to the computer means for selecting one of said at least two chromatograms, i.e. y, as a reference chromatogram y and for designating at least two principal peaks y p (p=1, . . . n; n≧2); said setting means being used to also select another of said at least two chromatograms, i.e. x, as a chromatogram x to be compared with the reference chromatogram y and to designate principal peaks x p (p=1, . . . n; n≧2) of the same number as that of the designated principal peaks y p of the reference chromatogram y; the computer means operating to derive, from the retention times x i and y i (i=1, . . . n; n≧2) of said designated principal peaks x p and y p of the two chromatograms x and y, one function for converting the time axis of the retention times x i to substantially the same time axis as that of the retention times y i with a minimum estimated error; and said computer means operating to further calculate, on the basis of said derived function, the modified retention times x' j of all the peaks of the chromatograms x.
Claim 2
Dependent Claim
263 words
A data processing system used in combination with a chromatography apparatus and adapted to modify one of at least two chromatograms x and y so that these chromatograms x and y can be compared with each other on the same time axis, comprising: memory means for storing data representative of said at least two chromatograms x and y; computer means coupled to the memory means; setting means coupled to the computer means for selecting one of said at least two chromatograms, i.e. y, as a reference chromatogram y and for designating at least two principal peaks y p (p=1, . . . n; n≧2); said setting means being used to also select another of said at least two chromatograms, i.e. x, as a chromatogram x to be compared with the reference chromatogram y and to designate principal peaks x p (p=1, . . . n; n≧2) of the same number as that of the designated principal peaks y p of the reference chromatogram y; the computer means operating to derive, from the retention times x i and y i (i=1, . . . n; n≧2) of said designated principal peaks x p and y p of the two chromatograms x and y, one function for converting the time axis of the retention times x i to substantially the same time axis as that of the retention times y i with a minimum estimated error; and said computer means operating to further calculate, on the basis of said derived function, the modified retention times x' j of all the peaks of the chromatograms x.
Claim 3
Dependent Claim
65 words
A data processing system as set forth in claim 1 wherein said computer means is programmed to calculate y.sub.i =ax.sub.i +b+ξ.sub.i . . . (i=1, . . . n) where ##EQU9## then to determine coefficients a and b with ##EQU10## being minimum, and further to obtain said modified retention time x' j on the basis of a linear regression function: x' j =ax j +b.
Claim 4
Dependent Claim
133 words
A data processing system as set forth in claim 2 wherein: said setting means is adapted to cause said computer means to read out, from said memory means, retention time x i and y i (i=1, . . . , n; n≧3) of at least three principal peaks of the chromatograms x and y, respectively; and said computer means is programmed to derive said linear regression function in each interval defined by each pair of adjacent retention times x k and x k+1 (k=1 to n-1); said computer means being operative to also convert respective retention time x j of peaks in the respective intervals x k -x k+1 of said chromatogram x to modified retention times x' j by the linear regression function for the corresponding interval x k -x k+1 .
Claim 5
Dependent Claim
96 words
A data processing system as set forth in claim 1 wherein: said setting means is adapted to cause said computer means to read out, from said memory means, retention time x i and y i (i=1, . . . , n; n≧3) of at least three principal peaks of the chromatograms x and y, respectively; and said computer means is programmed to derive one function capable of converting the time axis of the retention times x i to substantially the same time axis as that of the retention times y i with a minimum estimated error.
Claim 6
Dependent Claim
39 words
A data processing system as set forth in claim 4 wherein said computer means is programmed to use, as said function, a Spline Function using, as a knot, at least one of said principal peaks of said chromatogram x.
Claim 7
Dependent Claim
31 words
A data processing system as set forth in claim 5 wherein said computer means is programmed to use all the retention times x i of said principal peaks as the knots.
Claim 8
Dependent Claim
67 words
A data processing system as set forth in claim 6 wherein said computer means is programmed to use, as said Spline Function, a natural cubic Spline Function expressed for each interval [x j-1 , x j ] as follows: ##EQU11## wherein h j =x j -x j-1 , and M j may be calculated according to the following simultaneous equations: ##EQU12## where M o =M n =0.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-26 | 1991-10-26 | 1992-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-26 | 1995-10-26 | 1996-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-26 | 1999-10-26 | 2000-04-26 | $7700.00 | Window Closed / Lapsed |