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US4737579A
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Monoclonal antibodies for human non-small cell lung carinomas
Assignee: Oncogen LP
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Filing: 1986-07-23
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Granted: 1988-04-12
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Expires: 2006-07-23
Abstract
Abstract The present invention is concerned with novel monoclonal antibodies which define antigens associated with human non-small cell lung carcinomas ("NSCLC"). The antibodies bind to normal human cells to a lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods.
Inventors
- 👤 Ingegerd Hellstrom
- 👤 Joseph P. Brown
- 👤 Karl E. Hellstrom
- 👤 Diane Horn
- 👤 Peter Linsley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 07:05
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4748; A; A61; A61P; A61P35/00; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3023; A61K; A61K39/00; Y; Y10; Y10S; Y10S530/00; Y10S530/863; Y10S530/864; Y10S530/866
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
57 words
A monoclonal antibody, the antigen-combining site of which binds to: (a) a protein antigen having a molecular weight of about 80,000 daltons and which is a cell-surface determinant of human non-small cell lung carcinoma; and (b) a protein antigen having a molecular weight of about 100,000 daltons and which is secreted by human non-small cell lung carcinoma.
Claim 2
Dependent Claim
57 words
A monoclonal antibody, the antigen-combining site of which binds to: (a) a protein antigen having a molecular weight of about 80,000 daltons and which is a cell-surface determinant of human non-small cell lung carcinoma; and (b) a protein antigen having a molecular weight of about 100,000 daltons and which is secreted by human non-small cell lung carcinoma.
Claim 3
Dependent Claim
14 words
An Fab, F(ab') 2 or Fv fragment of the monoclonal antibody of claim 1.
Claim 4
Dependent Claim
16 words
The monoclonal antibody of claim 1 conjugated to a label capable of producing a detectable signal.
Claim 5
Dependent Claim
13 words
The monoclonal antibody of claim 3 in which the label comprises a fluorescer.
Claim 6
Dependent Claim
11 words
The monoclonal antibody of claim 1 which comprises an IgG isotype.
Claim 7
Dependent Claim
15 words
The monoclonal antibody of claim 1 which is produced by a murine hybridoma cell line.
Claim 8
Dependent Claim
25 words
The monoclonal antibody of claim 6 in which the murine hybridoma comprises a hybridoma having the identifying characteristics of HB8626 as deposited with the A.T.C.C.
Claim 9
Dependent Claim
14 words
An Fab, F(ab') 2 or Fv fragment of the monoclonal antibody of claim 7.
Claim 10
Dependent Claim
33 words
A monoclonal antibody, the antigen-combining site of which binds to a protein antigen having a molecular weight of about 140,000 daltons and which is a cell-surface determinant of human non-small cell lung carcinoma.
Claim 11
Dependent Claim
33 words
A monoclonal antibody, the antigen-combining site of which binds to a protein antigen having a molecular weight of about 140,000 daltons and which is a cell-surface determinant of human non-small cell lung carcinoma.
Claim 12
Dependent Claim
14 words
An Fab, F(ab') 2 or Fv fragment of the monoclonal antibody of claim 9.
Claim 13
Dependent Claim
16 words
The monoclonal antibody of claim 9 conjugated to a label capable of producing a detectable signal.
Claim 14
Dependent Claim
13 words
The monoclonal antibody of claim 11 in which the label comprises of fluorescer.
Claim 15
Dependent Claim
11 words
The monoclonal antibody of claim 9 which comprises an IgM isotype.
Claim 16
Dependent Claim
15 words
The monoclonal antibody of claim 9 which is produced by a murine hybridoma cell line.
Claim 17
Dependent Claim
25 words
The monoclonal antibody of claim 14 in which the murine hybridoma comprises a hybridoma having the identifying characteristics of HB8627 as deposited with the A.T.C.C.
Claim 18
Dependent Claim
14 words
An Fab, F(ab') 2 or Fv fragment of the monoclonal antibody of claim 15.
Claim 19
Dependent Claim
33 words
A monoclonal antibody, the antigen-combining site of which binds to a protein antigen having a molecular weight of about 72,000 daltons and which is a cell-surface determinant of human non-small cell lung carcinoma.
Claim 20
Dependent Claim
33 words
A monoclonal antibody, the antigen-combining site of which binds to a protein antigen having a molecular weight of about 72,000 daltons and which is a cell-surface determinant of human non-small cell lung carcinoma.
Claim 21
Dependent Claim
14 words
An Fab, F(ab') 2 or Fv fragment of the monoclonal antibody of claim 17.
Claim 22
Dependent Claim
16 words
The monoclonal antibody of claim 17 conjugated to a label capable of producing a detectable signal.
Claim 23
Dependent Claim
13 words
The monoclonal antibody of claim 19 in which the label comprises a fluorescer.
Claim 24
Dependent Claim
11 words
The monoclonal antibody of claim 17 which comprises an IgG isotype.
Claim 25
Dependent Claim
15 words
The monoclonal antibody of claim 17 which is produced by a murine hybridoma cell line.
Claim 26
Dependent Claim
25 words
The monoclonal antibody of claim 22 in whih the murine hybridoma comprises a hybridoma having the identifying characteristics of HB8628 as deposited with the A.T.C.C.
Claim 27
Dependent Claim
14 words
An Fab, F(ab') 2 or Fv fragment of the monoclonal antibody of claim 23.
References Cited (Backward Citations)
US4172124A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-12 | 1991-10-12 | 1992-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-12 | 1995-10-12 | 1996-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-12 | 1999-10-12 | 2000-04-12 | $7700.00 | Window Closed / Lapsed |