Patent US4737560A successfully refreshed from Google Patents.
US4737560A
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US
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Polymer beads
Assignee: 3M Co
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Filing: 1987-03-13
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Granted: 1988-04-12
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Expires: 2007-03-13
Abstract
Abstract Azlactone-functional polymer beads are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, reagents, and as enzyme or other protein-bearing supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads. Azlactone-functional beads have units of the formula: ##STR1## wherein R 1 is H or CH 3 , R 2 and R 3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R 1 and R 3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms,and n is an integer 0 or 1.
Inventors
- 👤 Steven M. Heilmann
- 👤 Jerald K. Rasmussen
- 👤 Larry R. Krepski
- 👤 Dean S. Milbrath
- 👤 Patrick L. Coleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 23:09
CPC Classifications
C; C07; C07K; C07K17/00; C07K17/02; C07K17/08; C08; C08F; C08F20/00; C08F20/02; C08F20/52; C08F20/54; C08F20/58; C08F8/00; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
50 words
A carboxylate-functional polymeric bead which is the aqueous phase reaction product of: (i) 0 to 98 parts of free radically addition polymerizable, water soluble monomers, (ii) 1 to 99 parts of a water soluble salt of N-(meth)acryloylamino acid, and (iii) 1 to 30 parts of at least one crosslinking monomer.
Claim 2
Dependent Claim
50 words
A carboxylate-functional polymeric bead which is the aqueous phase reaction product of: (i) 0 to 98 parts of free radically addition polymerizable, water soluble monomers, (ii) 1 to 99 parts of a water soluble salt of N-(meth)acryloylamino acid, and (iii) 1 to 30 parts of at least one crosslinking monomer.
Claim 3
Dependent Claim
38 words
A carboxylate-functional bead according to claim 1 having units of the formula: ##STR15## wherein R 1 , R 2 , R 3 and n are as previously defined, and M is a water-solubilizing cation, and n=0 or 1.
Claim 4
Dependent Claim
21 words
The carboxylate-functional bead according to claim 2 wherein R 1 , R 2 , and R 3 are methyl and n=0.
Claim 5
Independent Claim
59 words
A method comprising the steps of: (a) polymerizing together (i) 0 to 98 parts of at least one free radically addition polymerizable, water soluble monomer, (ii) 1 to 99 parts of at least one water soluble salt of N-(meth)acryloylamino acid, and (iii) 1 to 30 parts of at least one crosslinking monomer, (b) isolating the resulting carboxylate-functional polymer beads.
Claim 6
Independent Claim
59 words
A method comprising the steps of: (a) polymerizing together (i) 0 to 98 parts of at least one free radically addition polymerizable, water soluble monomer, (ii) 1 to 99 parts of at least one water soluble salt of N-(meth)acryloylamino acid, and (iii) 1 to 30 parts of at least one crosslinking monomer, (b) isolating the resulting carboxylate-functional polymer beads.
Claim 7
Dependent Claim
28 words
The method according to claim 4 further comprising the steps of: (c) reacting said carboxylate-functional beads with a cyclizing agent, and (d) isolating the resulting azlactone-functional polymer beads.
Claim 8
Dependent Claim
38 words
The method according to claim 5 further comprising the steps of: (e) reacting the azlactone-functional polymer beads with a functional material capable of reacting with said azlactone in a ring-opening reaction, and (f) isolating the resulting adduct beads.
Claim 9
Dependent Claim
15 words
The method according to claim 6 wherein said step (e) takes place in aqueous solution.
Claim 10
Dependent Claim
22 words
The method according to claim 6 wherein said functional material is selected from the group consisting of proteins, catalysts, reagents, and dyes.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-12 | 1991-10-12 | 1992-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-12 | 1995-10-12 | 1996-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-12 | 1999-10-12 | 2000-04-12 | $7700.00 | Window Closed / Lapsed |