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US4736019A
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Process for the separation of antifactor VIII:C antibodies, more particularly usable for the purification of the blood plasma of a type a hemophiliac
Assignee: Oris Industrie SA
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Filing: 1986-05-21
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Granted: 1988-04-05
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Expires: 2006-05-21
Abstract
Abstract The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain substitutable groups, whereof at least part is substituted by groups having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies compared with other immunoglobulins and then separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies. Preferably use is made of polystyrene, to which have been fixed groups -SO3Na and -SO2Glu, -SO2Threo, -SO2OHPro or SO2Lys. These supports can be used for ex-vivo purification in the column of the blood plasma of a type A hemophiliac.
Inventors
- 👤 Noureddine Bellattar
- 👤 Danielle Gulino
- 👤 Jacqueline Jozefonvicz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:33
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61M1/3616; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811; Y10S530/812; Y10S530/813; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
145 words
A process for the separation of antiVIII:C antibodies present in a liquid, which comprises: (a) contacting said liquid with a solid support constituted by a polymer or copolymer having substitutable groups in its chain and whereof at least part is substituted by groups of formula --(SO 3 ) x M, in which M represents a metal which does not react with the liquid and x represent the valency of M, groups of formula --SO 2 Y, or groups of formula --COY, in which Y represents a radical obtained by removing a hydrogen atom from the amino function of an α-amino acid other than arginine or an α-amino acid derivative other than arginine having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies with respect to other immunoglobulins and (b) separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies.
Claim 2
Dependent Claim
145 words
A process for the separation of antiVIII:C antibodies present in a liquid, which comprises: (a) contacting said liquid with a solid support constituted by a polymer or copolymer having substitutable groups in its chain and whereof at least part is substituted by groups of formula --(SO 3 ) x M, in which M represents a metal which does not react with the liquid and x represent the valency of M, groups of formula --SO 2 Y, or groups of formula --COY, in which Y represents a radical obtained by removing a hydrogen atom from the amino function of an α-amino acid other than arginine or an α-amino acid derivative other than arginine having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies with respect to other immunoglobulins and (b) separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies.
Claim 3
Dependent Claim
57 words
A process according to claim 1, wherein radical Y is in accordance with the formula: ##STR11## in which R 1 represents the side chain of an α-amino acid and R 2 a hydrogen atom or an alkyl radical, the radical R 1 having at least one function chosen from among the functions COOH,--NH 2 ,--OH and --SH.
Claim 4
Dependent Claim
25 words
A process according to claim 1, wherein the radical Y is obtained by removing a hydrogen atom from the amino function of the glutamic acid.
Claim 5
Dependent Claim
23 words
A process according to claim 1, wherein the radical Y is obtained by removing a hydrogen atom from the amino function of hydroxyproline.
Claim 6
Dependent Claim
23 words
A process according to claim 1, wherein the radical Y is obtained by removing a hydrogen atom from the amino function of threonine.
Claim 7
Dependent Claim
32 words
A process according to claim 1, wherein the radical Y is obtained by removing a hydrogen atom from the amino function of an amino acid chosen from among alanine, phenylalanine and lysine.
Claim 8
Dependent Claim
81 words
A process according to any one of the claims 1 to 6, wherein said support is constituted by polystyrene or a styrene copolymer to which are fixed groups of formula --SO 2 Y, in which Y has the meaning given in any one of the the claims 1 to 6 and groups of formula --(SO 3 ) x M, in which M represents a metal which does not react with the liquid and x represents the valency of the metal M.
Claim 9
Dependent Claim
17 words
A process according to claim 7, wherein the styrene copolymer is constituted by a styrene-grafted, chlorosulphonation-resistant polymer.
Claim 10
Dependent Claim
19 words
A process according to claim 8, wherein the chlorosulphonation-resistant polymer is chosen from among polyolefins, fluorinated polymers and polyvinylchloride.
Claim 11
Dependent Claim
89 words
A process according to any one of the claims 1 to 6, wherein said support is constituted by a polysaccharide, to which are fixed groups of formula --COY, in which Y has the meaning given in any one of the claims 1 to 6, and groups of formula CH 2 CONHR 4 --SO 3 R 5 , in which R 4 represents an alkyl, aryl or alkylaryl which may or may not be substituted and R 5 represents a hydrogen atom or a metal not reacting with the liquid.
Claim 12
Dependent Claim
12 words
A process according to claim 10, wherein the polysaccharide is a polydextran.
Claim 13
Dependent Claim
18 words
A process according to any one of the claims 1 to 11 wherein the liquid is blood plasma.
Claim 14
Dependent Claim
30 words
An application of the process according to any one of the claims 1 to 11, to the ex-vivo purification of the blood of a patient suffering from type A hemophilia.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-05 | 1991-10-05 | 1992-04-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-05 | 1995-10-05 | 1996-04-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-05 | 1999-10-05 | 2000-04-05 | $7700.00 | Window Closed / Lapsed |