Inorganic-organic compound substances for biomedical purposes

Claim 1

Inorganic-organic compound substances useful for biomedical purposes, comprising 30 to 80 weight-% of an inorganic initial material chemically bonded with 20 to 70 weight-% of an organic initial material, wherein the inorganic initial material is selected from the group consisting of a biocompatable silicate glass, silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate apatite or mixtures thereof and mixtures thereof, and the organic initial material comprises a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, wherein the inorganic initial material has been pretreated with phosphoric acid to facilitate said chemical bonding between the organic and inorganic initial materials.

Claim 10

A method of producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 30 to 50% H 3 PO 4 for 1 to 24 hours at 25° to 130° C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof; mixing 30 to 80 weight-% of said treated inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, at a temperature of 45° C. or less, to form a final reacted and chemically bonded inorganic-organic material resembling bone or cartilage suitable for endoprostheses, bone defect substitutions and body cartilage replacements, whereby said treatment with H 3 PO 4 facilitates said chemical bonding.

Claim 11

A method of producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 30 to 50% H 3 PO 4 for 1 to 24 hours at 25° to 130° C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof; mixing 30 to 80 weight-% of said treated inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, at a temperature of 45° C. or less, to form a final reacted and chemically bonded inorganic-organic material resembling bone or cartilage suitable for endoprostheses, bone defect substitutions and body cartilage replacements, whereby said treatment with H 3 PO 4 facilitates said chemical bonding.

Claim 12

A method for producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 30 to 50% H 3 PO 4 for 1 to 24 hours at 25° to 130° C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof;

Claim 13

A method for producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 30 to 50% H 3 PO 4 for 1 to 24 hours at 25° to 130° C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof;

Claim 16

A method of producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 50% H 3 PO 4 for 12 hours at 110° C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof; mixing 30 to 80 weight-% of said inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, to form a reacted and chemically bonded inorganic-organic material hardening to within 80% of final hardness within 20 minutes after mixing suitable for use as a tooth filling material and tooth structure material, whereby said treatment with H 3 PO 4 facilitates said chemical bonding.

Claim 17

A method of producing inorganic-organic compound substances useful for biomedical purposes, comprising treating an inorganic initial material with 50% H 3 PO 4 for 12 hours at 110° C., said inorganic initial material being selected from the group consisting of a biocompatible silicate glass, a silicate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 34-60 Al.sub.2 O.sub.3 = 21-36 MgO = 8-17 R.sub.2 O = 5-12 F.sup.- = 1-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-6 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (A) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 19-52 Al.sub.2 O.sub.3 = 12-23 MgO 5-15 R.sub.2 O = 3-10 CaO = 9-30 P.sub.2 O.sub.5 4-24 F.sup.- 0.5-7 ______________________________________ wherein R 2 O represents the sum of 0-8 weight-% Na 2 O and 0-8 weight-% K 2 O, a bioactive phosphosilicate glass, a phosphosilicate glass ceramic (B) or mixtures thereof having a composition by weight % of ______________________________________ SiO.sub.2 = 18-63 MgO = 10-35 K.sub.2 O = 3-10 F.sup.- = 4-9 CaO = 1-30 P.sub.2 O.sub.5 = 1-30 ______________________________________ a bioactive phosphate glass, a phosphate glass ceramic or mixtures thereof having a composition by weight % of ______________________________________ P.sub.2 O.sub.5 = 43-58 Al.sub.2 O.sub.3 = 3-21 CaO = 8-26 R.sub.2 O = 10-25 ______________________________________ wherein R 2 O can contain up to 25 weight-% Na 2 O and up to 18 weight-% K 2 O, a sintered ceramic comprising tricalcium phosphate, apatite and mixtures thereof; mixing 30 to 80 weight-% of said inorganic initial material with 20 to 70 weight-% of an organic initial material comprising a biocompatible, monomer-free, epoxidized polymeric hydrocarbon composed only of the elements C, H, O having an average molecular weight Mn of 2,000 to 6,000 and an epoxy equivalence EEW of 50 to 500 g, to form a reacted and chemically bonded inorganic-organic material hardening to within 80% of final hardness within 20 minutes after mixing suitable for use as a tooth filling material and tooth structure material, whereby said treatment with H 3 PO 4 facilitates said chemical bonding.