US4731241A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Percutaneous pharmaceuticals preparation for external use
Assignee: Sanofi Aventis Deutschland GmbH
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Filing: 1987-03-09
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Granted: 1988-03-15
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Expires: 2007-03-09
Abstract
Abstract A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of aliphatic monoalcohols of 10 to 22 carbon atoms, aliphatic monoamides of 8 to 18 carbon atoms and aliphatic monoamines of 10 to 16 carbon atoms gives a high blood concentration of molsidomine over a long time period when applied onto the human skin.
Inventors
- 👤 Masayuki Yamada
- 👤 Yoshiaki Uda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K31/00; A61K31/33; A61K31/395; A61K31/535; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/12; A61K47/16; A61K47/18; A61K9/0012; A61K9/0014; A61P; A61P9/00; A61P9/08
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
39 words
A percutanneous pharmaceutical preparation for external application which comprises (a) N-ethoxycarbonyl-3-morpholinosydnonimine; and (b) at least 0.01 weight part of an absorption promoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
Claim 2
Dependent Claim
39 words
A percutanneous pharmaceutical preparation for external application which comprises (a) N-ethoxycarbonyl-3-morpholinosydnonimine; and (b) at least 0.01 weight part of an absorption promoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
Claim 3
Dependent Claim
34 words
A percutaneous pharmaceutical preparation claimed in claim 1, wherein the proportion of N-ethoxyoarbonyl-3morpholinosydnonimine and the absorption promoter to the whole preparation are 0.1 to 40% by weight and more than 0.1% by weight, respectively.
Claim 4
Dependent Claim
17 words
A percutaneous pharmaceutical preparation for external application of claim 1 wherein said absorption prometer is oleic acid.
Claim 5
Dependent Claim
53 words
A percutaneous pharmaceutical drug delivery system which comprises a support material having adhered or deposited thereon a preparation for external application which comprises (a) N-ethoxycarbonyl-3-morpholinosydnonimine; and (b) at least 0.01 weight part of an absorption propmoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
Claim 6
Dependent Claim
53 words
A percutaneous pharmaceutical drug delivery system which comprises a support material having adhered or deposited thereon a preparation for external application which comprises (a) N-ethoxycarbonyl-3-morpholinosydnonimine; and (b) at least 0.01 weight part of an absorption propmoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
Claim 7
Independent Claim
42 words
A method of percutaneously administering a vasodilator effect to a patient which comprises the percutaneous administration of N-ethoxycarbonyl-3-morpholinosydnonimine as 0.01 weight part absorption promoter per part of said vasodilator, said absorption promoter being an aliphatic monocarboxylic acid of 5 to 30 carbons.
Claim 8
Independent Claim
42 words
A method of percutaneously administering a vasodilator effect to a patient which comprises the percutaneous administration of N-ethoxycarbonyl-3-morpholinosydnonimine as 0.01 weight part absorption promoter per part of said vasodilator, said absorption promoter being an aliphatic monocarboxylic acid of 5 to 30 carbons.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-15 | 1991-09-14 | 1992-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-15 | 1995-09-14 | 1996-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-15 | 1999-09-14 | 2000-03-15 | $7700.00 | Window Closed / Lapsed |