US4730053A
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S-[2-phenyl (alkyl) carbamoyl]-phenylselenylmercapto derivatives
Assignee: A Natterman und Cie GmbH
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Filing: 1985-11-25
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Granted: 1988-03-08
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Expires: 2005-11-25
Abstract
Abstract The present invention is related to new S-(Carbamoyl-phenylselenyl) derivatives of mercaptanes of the general formula (I) ##STR1## and to a process for the treatment of diseases caused by cell injury due to the increased formation of active oxygen metabolites.
Inventors
- 👤 Norbert Dereu
- 👤 Albrecht Wendel
- 👤 Helmut Sies
- 👤 Sigurd Leyck
- 👤 Axel Romer
- 👤 Erich Graf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 08:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61P; A61P1/00; A61P1/16; A61P29/00; A61P43/00; A61P9/00; C; C07; C07C; C07C391/00; C07C391/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
131 words
A compound of formula (I) ##STR7## wherein R 1 , R 2 , R 3 and R 4 are identical or different from each other and represent members selected from the group consisting of hydrogen, halogen, C 1-4 -alkyl, C 1-3 -alkoxy, trifluoromethyl, nitro, cyano, hydroxy, carboxy, C 1-2 -alkoxycarbonyl, carboxy-C 1-4 -alkyl and C 1-2 -alkoxycarbonyl-C 1-4 -alkyl and A represents a member selected from the group constisting of the straight and branched alkyl groups having 1 to 4 carbon atoms and said alkyl groups substituted by 1 to 3 members selected from the group consisting of the carboxy, C 1-3 -alkoxycarbonyl, hydroxy, mercapto, carboxy-C 1-4 -alkylcarbamoyl, C 1-3 -alkoxycarbonyl C 1-4 -alkylcarbamoyl, phenyl, carboxyphenyl, C 1-3 -alkoxycarbonylphenyl, pyridyl and pyridyl-C 1-4 -alkyl groups, and n is zero or one.
Claim 2
Dependent Claim
131 words
A compound of formula (I) ##STR7## wherein R 1 , R 2 , R 3 and R 4 are identical or different from each other and represent members selected from the group consisting of hydrogen, halogen, C 1-4 -alkyl, C 1-3 -alkoxy, trifluoromethyl, nitro, cyano, hydroxy, carboxy, C 1-2 -alkoxycarbonyl, carboxy-C 1-4 -alkyl and C 1-2 -alkoxycarbonyl-C 1-4 -alkyl and A represents a member selected from the group constisting of the straight and branched alkyl groups having 1 to 4 carbon atoms and said alkyl groups substituted by 1 to 3 members selected from the group consisting of the carboxy, C 1-3 -alkoxycarbonyl, hydroxy, mercapto, carboxy-C 1-4 -alkylcarbamoyl, C 1-3 -alkoxycarbonyl C 1-4 -alkylcarbamoyl, phenyl, carboxyphenyl, C 1-3 -alkoxycarbonylphenyl, pyridyl and pyridyl-C 1-4 -alkyl groups, and n is zero or one.
Claim 3
Dependent Claim
124 words
A compound according to claim 1, wherein R 1 , R 2 , R 3 and R 4 are identical or different from each other and represent a member selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, hydroxy, trifluoromethyl, nitro, cyano, carboxy, C 1-2 -alkoxycarbonyl, carboxy-C 1-4 -alkyl and C 1-2 -alkoxycarbonyl-C 1-4 -alkyl, and A represents a member selected from the group consisting of the straight and branched alkyl groups containing 1 to 4 carbon atoms and said groups substituted by 1 to 3 members selected from the group consisting of carboxy, C 1-2 -alkoxycarbonyl, carboxy-C 1-4 -alkylcarbamoyl, C 1-2 -alkoxycarbonyl-C 1-4 -alkylcarbamoyl, and phenyl, carboxyphenyl, C 1-12 -alkoxycarbonylphenyl, pyridyl and pyridyl-C 1-4 -alkyl, and n is zero or one.
Claim 4
Dependent Claim
139 words
A compound according to claim 1, wherein R 1 and R 2 are identical or different from each other and represent a member selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, hydroxy, trifluoromethyl and nitro, and R 3 and R 4 are identical or different from each other and represent a member selected from the group consisting of hydrogen, fluorine, chlorine, ethoxy, hydroxy, cyano, carboxy, C 1-2 -alkoxycarbonyl, carboxy-C 1-4 -alkyl, C 1-2 -alkoxycarbonyl-C 1-4 -alkyl, and A represents a member selected from the group consisting of the straight and branched alkyl groups having 1 to 4 carbon atoms and said alkyl groups substituted by 1 to 3 members selected from the group consisting of carboxy, C 1-2 -alkoxycarbonyl, hydroxy, mercapto, carboxy-C 1-4 -alkylcarbamoyl and C 1-2 alkoxycarbonyl-C 1-4 -alkylcarbamoyl and n is zero or one.
Claim 5
Dependent Claim
129 words
A compound according to claim 1, wherein R 1 and R 2 are identical or different from each other and represent a member selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, hydroxy, trifluoromethyl, nitro, and R 3 and R 4 are identical or different from each other and represent a member selected from the group consisting of hydrogen, fluorine, chlorine, methoxy, hydroxy, cyano, carboxy, C 1-2 -alkoxycarbonyl, carboxy-C 1-4 -alkyl, C 1-2 -alkoxy-carbonyl-C 1-4 -alkyl, and A represents a member selected from the group consisting of the straight and branched alkyl groups having 1 to 4 carbon atoms and said alkyl groups substituted by 1 to 3 members selected from the group consisting of phenyl, carboxyphenyl, methoxycarbonylphenyl, pyridyl and pyridylmethyl, and n is zero or one.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-03-08 | 1991-09-07 | 1992-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-08 | 1995-09-07 | 1996-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-08 | 1999-09-07 | 2000-03-08 | $7700.00 | Window Closed / Lapsed |