US4618669A
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S-(carbamoyl-phenylselenyl) derivatives of glutathione and of aminomercaptocarboxylic acids
Assignee: A NATTERMANN & CIE NATTERMANNALLEE 1 D-5000 KOLN 30 GERMANY GmbH
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Filing: 1985-06-14
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Granted: 1986-10-21
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Expires: 2005-06-14
Abstract
Abstract The present invention relates to new S-(carbamoylphenylselenyl) derivatives of glutathione and of α-aminomercaptocarboxylic acids of the general formula (I) ##STR1##
Inventors
- 👤 Norbert Dereu
- 👤 Andre Welter
- 👤 Albrecht Wendel
- 👤 Sigurd Leyck
- 👤 Michael Parnham
- 👤 Erich Graf
- 👤 Helmut Sies
- 👤 Hans Betzing
- 👤 Hartmut Fischer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 09:12
CPC Classifications
C; C07; C07C; C07C391/00; C07C391/02
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
155 words
S-(Carbamoyl-phenylselenyl) derivatives of glutathione and of α-aminomercaptocarboxylic acids according to the general formula (I) ##STR7## wherein R 1 , R 2 , R 3 and R 4 , represent members selected from the group consisting of hydrogen, halogen, C 1-4 -alkyl, C 1-4 -alkoxy, trifluoromethyl, nitro, cyano, hydroxy, carboxy and C 1-4 -alkoxycarbonyl, n is zero or an integer from 1 to 4 and A is a member selected from the group consisting of the glutathione radical, the α-amino acid radicals, the α-amino acid radicals wherein the carboxylic group and the amino group are unsubstituted the α-amino acid radicals wherein the carboxylic group is esterified with a C 1-3 -alcohol and the amino group is unsubstituted, the α-amino acid radicals wherein the amino group is acylated and the carboxylic group is unsubstituted, and the α-amino acid radicals wherein both the carboxylic group is esterified with a C 1-3 -alcohol and the amino group is acylate
Claim 2
Dependent Claim
155 words
S-(Carbamoyl-phenylselenyl) derivatives of glutathione and of α-aminomercaptocarboxylic acids according to the general formula (I) ##STR7## wherein R 1 , R 2 , R 3 and R 4 , represent members selected from the group consisting of hydrogen, halogen, C 1-4 -alkyl, C 1-4 -alkoxy, trifluoromethyl, nitro, cyano, hydroxy, carboxy and C 1-4 -alkoxycarbonyl, n is zero or an integer from 1 to 4 and A is a member selected from the group consisting of the glutathione radical, the α-amino acid radicals, the α-amino acid radicals wherein the carboxylic group and the amino group are unsubstituted the α-amino acid radicals wherein the carboxylic group is esterified with a C 1-3 -alcohol and the amino group is unsubstituted, the α-amino acid radicals wherein the amino group is acylated and the carboxylic group is unsubstituted, and the α-amino acid radicals wherein both the carboxylic group is esterified with a C 1-3 -alcohol and the amino group is acylate
Claim 3
Dependent Claim
62 words
S-(Carbamoyl-phenylselenyl) derivatives of L-glutathione according to formu-a (I) in claim 1, wherein R 1 and R 2 are members selected from the group consting of hydrogen, fluorine, chlorine, methyl, methoxy, hydroxy, .trifluoromethyl and nitro, R 3 and R 4 are members selected from the group consisting of hydrogen, fluorine, chlorine, methoxy and hydroxy, n is zero and A represents the L-glutathione radical.
Claim 4
Dependent Claim
70 words
S-(Carbamoyl-phenylselenyl) derivatives of L-cysteine according to formula (I) of claim 1, wherein R 1 and R 2 are members selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy, hydroxy, trifluoromethyl and nitro, R 3 and R 4 are members selected from the group consisting of hydrogen, fluorine, chlorine, methyl, methoxy and hydroxy, n is zero or an integer from 1 to 4 and A represents the L-cysteine radical.
References Cited (Backward Citations)
US4352799A
Cited
US4418069A
Cited
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