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US4727077A
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Benzoyl urea compounds, process for their production, and antitumorous compositions containing them
Assignee: Ishihara Sangyo Kaisha Ltd
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Filing: 1986-01-29
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Granted: 1988-02-23
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Expires: 2006-01-29
Abstract
Abstract A benzoyl urea compound having the formula: <IMAGE> (I) wherein A is a bromine atom or a chlorine atom.
Inventors
- 👤 Takahiro Haga
- 👤 Nobutoshi Yamada
- 👤 Hideo Sugi
- 👤 Toru Koyanagi
- 👤 Nobuo Kondo
- 👤 Tsunetaka Nakajima
- 👤 Masahiro Watanabe
- 👤 Kazumasa Yokoyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/495; A61K31/505; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/30; A61K47/36; A61K47/40; A61K47/44; A61K9/0012; A61K9/0019; A61K9/20; A61K9/2004; A61K9/2013; A61K9/48; A61K9/4841; A61K9/4858; C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/34
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
18 words
A benzoyl urea compound having the formula: ##STR16## wherein A is a bromine atom or a chlorine atom.
Claim 2
Dependent Claim
18 words
A benzoyl urea compound having the formula: ##STR16## wherein A is a bromine atom or a chlorine atom.
Claim 3
Dependent Claim
11 words
The benzoyl urea compound according to claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]urea.
Claim 4
Dependent Claim
11 words
The benzoyl urea compound according to claim 1, which is N-(2-nitrobenzoyl)-N'-[3-chloro-4-(5-chloro-2-pyrimidinyloxy)phenyl]urea.
Claim 5
Dependent Claim
32 words
An antitumorous composition comprising: an antitumorously effective amount of a benzoyl urea compound having the formula: ##STR17## where A is a bromine atom or a chlorine atom and a pharmaceutically acceptable adjuvant.
Claim 6
Dependent Claim
32 words
An antitumorous composition comprising: an antitumorously effective amount of a benzoyl urea compound having the formula: ##STR17## where A is a bromine atom or a chlorine atom and a pharmaceutically acceptable adjuvant.
Claim 7
Dependent Claim
15 words
The antitumorous composition according to claim 4, wherein the pharmaceutically acceptable adjuvant is a surfactant.
Claim 8
Dependent Claim
18 words
The antitumorous composition according to claim 4, wherein the pharmaceutically acceptable adjuvant is a phospholipid and an antioxidant.
Claim 9
Dependent Claim
26 words
The antitumorous composition according to claim 4, wherein at least 80% of the benzoyl urea compound has a particle size of not larger than 5 μm.
Claim 10
Dependent Claim
18 words
The antitumorous composition according to claim 4, which is applied for oral administration, intravenous administration or suppository administration.
Claim 11
Dependent Claim
13 words
The antitumorous composition according to claim 4, which is applied for oral administration.
Claim 12
Independent Claim
54 words
A method of treating a cancer resulting from the growth of P-388 leukemia cells, L-1210 leukemia cells, B-16 melanoma cells and M-5074 ovarium sarcoma cells, comprising: administering to a host subject suffering from said cancer an antitumorously effective amount of a benzoyl urea compound of the formula: ##STR18## wherein A is bromine or chlorine.
Claim 13
Independent Claim
54 words
A method of treating a cancer resulting from the growth of P-388 leukemia cells, L-1210 leukemia cells, B-16 melanoma cells and M-5074 ovarium sarcoma cells, comprising: administering to a host subject suffering from said cancer an antitumorously effective amount of a benzoyl urea compound of the formula: ##STR18## wherein A is bromine or chlorine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-22 | 1991-08-24 | 1992-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-22 | 1995-08-24 | 1996-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-22 | 1999-08-24 | 2000-02-23 | $7700.00 | Window Closed / Lapsed |