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Method of treating smooth muscle spasm

Assignee: United Pharmaceuticals Inc
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Filing: 1986-04-15
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Granted: 1988-02-16
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Expires: 2006-04-15
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Abstract

Abstract A new method of treating a patient suffering smooth muscle spasm comprises administering to the patient an effective amount of anti-spasmodic compound having the general formula: ##STR1## where R is selected from the group consisting of: ##STR2## wherein W is CH 2 , NH, O or S, ##STR3## wherein Y is an alicyclic ring ring having 3-12 carbon atoms, and ##STR4## the total number of carbon atoms in R is equal to or less than 20. Furthermore, m is an integer from 1 to 4, n is an integer from 1 to 4, p is an integer from 1 to 4 and q is an integer from 1 to 4. X may be nonexistent or may be 0, S, NH or CH 2 or salts thereof. However, when X is nonexistent the terminal group in both the n-chain and the p-chain is a methyl group provided that a is zero or 1 and when a is 1, X is selected from the group consisting of 0, S, and CH 2 and n and p are integers from 1 to 4; and when a is 0 then X is nonexistent and n and p are integers from 1 to 4 and the terminal group in both the n-chain and the p-chain is methyl; and pharmaceutically acceptable salts thereof.

Inventors

  • 👤 William M. Davis

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-26 23:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/265

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 174 words
A method of treating a patient suffering smooth muscle spasm comprising administering to the patient an effective amount of a compound having the formula: ##STR14## wherein R is selected from the group consisting of: ##STR15## wherein W is CH 2 , NH, O or S, ##STR16## wherein Y is an alicyclic ring ring having 3-12 carbon atoms, and ##STR17## the total number of carbon atoms in R is equal to or less than 20, and wherein a is zero or 1 m is an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 1 to 4; and provided that when a is 1, X is selected from the group consisting of O, S, NH and CH 2 and n and p are integers from 1 to 4; and when a is O then X is nonexistent and n and p are integers from 1 to 4 and the terminal group in both the n-chain and the p-chain is a methyl; and pharmaceutically acceptable salts thereof.
Claim 2
Independent Claim 174 words
A method of treating a patient suffering smooth muscle spasm comprising administering to the patient an effective amount of a compound having the formula: ##STR14## wherein R is selected from the group consisting of: ##STR15## wherein W is CH 2 , NH, O or S, ##STR16## wherein Y is an alicyclic ring ring having 3-12 carbon atoms, and ##STR17## the total number of carbon atoms in R is equal to or less than 20, and wherein a is zero or 1 m is an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 1 to 4; and provided that when a is 1, X is selected from the group consisting of O, S, NH and CH 2 and n and p are integers from 1 to 4; and when a is O then X is nonexistent and n and p are integers from 1 to 4 and the terminal group in both the n-chain and the p-chain is a methyl; and pharmaceutically acceptable salts thereof.
Claim 3
Independent Claim 90 words
A method of treating a patient suffering smooth muscle spasm comprising administering to the patient an effective amount of a compound having the formula: ##STR18## wherein R is ##STR19## the total number of carbon atoms in R is equal to or less than 12, and wherein m is an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 1 to 4; and the terminal group in both the n-chain and the p-chain is a methyl group; and pharmaceutically acceptable salts thereof.
Claim 4
Independent Claim 90 words
A method of treating a patient suffering smooth muscle spasm comprising administering to the patient an effective amount of a compound having the formula: ##STR18## wherein R is ##STR19## the total number of carbon atoms in R is equal to or less than 12, and wherein m is an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 1 to 4; and the terminal group in both the n-chain and the p-chain is a methyl group; and pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim 30 words
The method as defined in claim 1 or 2, wherein the compound is administered in a dosage of from about 1 to about 15 mg/kg of body weight per day.
Claim 6
Dependent Claim 30 words
The method as defined in claim 1 or 2, wherein the compound is administered in a dosage of from about 1.5 to about 11.5 mg/kg of body weight per day.
Claim 7
Dependent Claim 30 words
The method as defined in claim 1 or 2, wherein the compound is administered in a dosage of from about 3 to about 6 mg/kg of body weight per day.
Claim 8
Dependent Claim 19 words
The method as defined in claim 1 or 2, wherein the compound is combined with a pharmaceutically acceptable carrier.

References Cited (Backward Citations)

US2390555A Cited
DE2003680A1 Cited
US4432977A Cited
US4647562A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1991-02-15 1991-08-17 1992-02-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1995-02-15 1995-08-17 1996-02-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1999-02-15 1999-08-17 2000-02-16 $7700.00 Window Closed / Lapsed

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