US4725434A
Expired / Lapsed
US
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Process for the preparation of a free flowing, homogeneous, iodophor containing wound powder
Assignee: Euro Celtique SA
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Filing: 1986-03-03
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Granted: 1988-02-16
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Expires: 2006-03-03
Abstract
Abstract A free flowing iodophor powder which can be used for the treatment of wounds and the like, is prepared by spraying a solution of the iodophor in an aqueous-alcoholic solvent having a boiling point at normal pressure of less than 100° C. into a fluidized bed of a finely divided sugar. This results in the formation of a free flowing powder which is well tolerated upon application to wounds.
Inventors
- 👤 Tjoe H. Jauw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:09
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/18; A01; A01N; A01N59/00; A01N59/12; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/1623; A61P; A61P17/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
84 words
Method of preparing a homogenous, free flowing powdered iodophor, which comprises introducing a finely divided sugar into a fluidized bed granulator to form a fluidized bed of said finely divided sugar, spraying a solution of an iodophor in an aqueous-alcoholic solvent having a boiling point at 760 mm Hg of less than 100° C. into said fluidized bed of said finely divided sugar, whereby a homogenous, free flowing powder is formed containing said iodophor, which powder can be applied to wounds and the like.
Claim 2
Dependent Claim
84 words
Method of preparing a homogenous, free flowing powdered iodophor, which comprises introducing a finely divided sugar into a fluidized bed granulator to form a fluidized bed of said finely divided sugar, spraying a solution of an iodophor in an aqueous-alcoholic solvent having a boiling point at 760 mm Hg of less than 100° C. into said fluidized bed of said finely divided sugar, whereby a homogenous, free flowing powder is formed containing said iodophor, which powder can be applied to wounds and the like.
Claim 3
Dependent Claim
11 words
Method according to claim 1 wherein the sugar is a disaccharide.
Claim 4
Dependent Claim
15 words
Method according to claim 1 wherein the sugar is sucrose, dextrose, maltose, fructose or lactose.
Claim 5
Dependent Claim
10 words
Method according to claim 1 wherein the sugar is sucrose.
Claim 6
Dependent Claim
31 words
Method according to claim 1 wherein the sugar has a particle size of 250 microns or less with at least 90% thereof having a particle size of 150 microns or less.
Claim 7
Dependent Claim
14 words
Method according to claim 1 wherein the iodophor is polydextrose iodine or povidone iodine.
Claim 8
Dependent Claim
11 words
Method according to claim 1 wherein the iodophor is povidone iodine.
Claim 9
Dependent Claim
31 words
Method according to claim 1 wherein the iodine content of the iodophor is adjusted to an amount such that the resulting powder contains between 0.1 and 2.0% by weight of iodine.
Claim 10
Dependent Claim
17 words
Method according to claim 8 wherein the amount of iodine is between 0.2 and 1.5% by weight.
Claim 11
Dependent Claim
12 words
Method according to claim 1 wherein the alcohol is an alkyl alcohol.
Claim 12
Dependent Claim
13 words
Method according to claim 1 wherein the alcohol is methanol, ethanol or isopropanol.
Claim 13
Dependent Claim
10 words
Method according to claim 1 wherein the alcohol is ethanol.
Claim 14
Dependent Claim
25 words
Method according to claim 1 wherein the solvent contains 70-95% by volume of an alkyl alcohol and between 30 and 15% by volume of water.
Claim 15
Dependent Claim
24 words
Method according to claim 13 wherein the amount of alkyl alcohol is 78-80% by volume and the amount of water is 22-20% by volume.
Claim 16
Dependent Claim
42 words
Method according to claim 1 wherein the pH of the iodophor solution prior to spraying is adjusted to a value such that a 50% weight to volume aqueous solution of the resulting powder has a pH of between about 3.0 and 7.0.
Claim 17
Dependent Claim
14 words
Method according to claim 15 wherein the pH value is between 4.0 and 6.0.
Claim 18
Dependent Claim
12 words
The free flowing powdered iodophor produced by the process of claim 1.
Claim 19
Dependent Claim
21 words
Method according to claim 1 wherein the resulting powder is mixed with polyethylene glycol, a carboxyalkylcellulose, a hydroxyalkylcellulose or zinc oxide.
Claim 20
Dependent Claim
12 words
The free flowing iodophor powder produced by the method of claim 18.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-15 | 1991-08-17 | 1992-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-15 | 1995-08-17 | 1996-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-15 | 1999-08-17 | 2000-02-16 | $7700.00 | Window Closed / Lapsed |