US4721704A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Potent synthetic atrial peptide analogs
Assignee: Peninsula Laboratories Inc
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Filing: 1986-05-09
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Granted: 1988-01-26
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Expires: 2006-05-09
Abstract
Abstract Biologically active atrial peptide analogs having 21 or 22 amino acid residues are provided with potent diuretic and natriuretic activities, and which lower blood pressure. These analogs have a β-mercaptopropanoic acid derivative moiety at the N-terminus and have D-Alanine at the 3 position of the amino acid sequence.
Inventors
- 👤 Jaw-Kang Chang
- 👤 Ding Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:04
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/58; C07K14/582
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
40 words
An atrial peptide analog having the structure ##STR11## wherein Mpr is a β-mercaptopropanoic acid derivative, R 1 is Gly or D-Ala, R 2 is Gly or D-Ala, and R 3 is OH, NH 2 , Tyr-OH, or Tyr-NH 2 .
Claim 2
Dependent Claim
40 words
An atrial peptide analog having the structure ##STR11## wherein Mpr is a β-mercaptopropanoic acid derivative, R 1 is Gly or D-Ala, R 2 is Gly or D-Ala, and R 3 is OH, NH 2 , Tyr-OH, or Tyr-NH 2 .
Claim 3
Dependent Claim
16 words
The atrial peptide analog as in claim 1 wherein R 1 and R 2 are Gly.
Claim 4
Dependent Claim
17 words
The atrial peptide analog as in claim 2 wherein R 3 is Tyr-OH or Tyr-NH 2 .
Claim 5
Dependent Claim
15 words
The atrial peptide analog as in claim 2 wherein R 3 is Tyr-NH 2 .
Claim 6
Dependent Claim
29 words
The atrial peptide analog as in claim 1 wherein one of R 1 and R 2 is Gly and the other of R 1 and R 2 is D-Ala.
Claim 7
Dependent Claim
18 words
The atrial peptide analog as in claim 5 wherein R 3 is NH 2 or Tyr-NH 2 .
Claim 8
Dependent Claim
25 words
A therapeutic composition for producing diuresis, natriuresis, or for lowering blood pressure comprising a therapeutically effective amount of the atrial peptide analog of claim 1.
Claim 9
Dependent Claim
30 words
A method for producing diuresis, natriuresis or for lowering blood pressure in a mammal comprising administering to said mammal a therapeutically effective amount of the peptide analog of claim 1.
Claim 10
Dependent Claim
26 words
The method as in claim 8 wherein the therapeutically effect:ve amount is from about 100 μg to about 400 μg and is administered by I.V. bolus.
Claim 11
Independent Claim
64 words
A method for the treatment of edema or hypertension which comprises administering to a mammal afflicted with edema or hypertension an effective amount of a peptide having the formula ##STR12## wherein Mpr is moiety having the structure ##STR13## and R 1 is Gly or D-Ala, R 2 is Gly or D-Ala, and R 3 is OH, NH 2 , Tyr-OH or Tyr-NH 2 .
Claim 12
Independent Claim
64 words
A method for the treatment of edema or hypertension which comprises administering to a mammal afflicted with edema or hypertension an effective amount of a peptide having the formula ##STR12## wherein Mpr is moiety having the structure ##STR13## and R 1 is Gly or D-Ala, R 2 is Gly or D-Ala, and R 3 is OH, NH 2 , Tyr-OH or Tyr-NH 2 .
Claim 13
Dependent Claim
16 words
The method as in claim 10 wherein the peptide is formulated with a physiologically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-25 | 1991-07-27 | 1992-01-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-25 | 1995-07-27 | 1996-01-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-25 | 1999-07-27 | 2000-01-26 | $7700.00 | Window Closed / Lapsed |