Patent US4720580A successfully refreshed from Google Patents.
US4720580A
Expired / Lapsed
US
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N-(aminoalkylene)benzenesulfonamides
Assignee: Wyeth LLC
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Filing: 1986-04-11
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Granted: 1988-01-19
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Expires: 2006-04-11
Abstract
Abstract This invention provides a group of anti-arrhythmic agents of the formula: ##STR1## in which R 1 is hydrogen, hydroxy, alkoxy or halo; R 2 is hydrogen, alkoxy, halo or trifluoromethyl, with the proviso that R 2 is not hydrogen when R 1 is hydrogen; R 3 is alkyl or, when R 2 is trifluoromethyl and R 1 is hydrogen, R 3 may be hydrogen; R 4 is alkyl, cycloalkyl or cycloalkylmethyl; R 5 is hydrogen or alkyl; n is 2-4; or a pharmaceutically acceptable salt thereof.
Inventors
- 👤 George C. Buzby, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:39
CPC Classifications
C; C07; C07C; C07C311/00; C07C311/15
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
90 words
A compound of the formula: ##STR4## in which R 1 is hydrogen, hydroxyl, alkoxy of 1 to 6 carbon atoms or halo; R 2 is hydrogen, halo or trifluoromethyl, with the proviso that R 2 is not hydrogen when R 1 is hydrogen; R 3 is isopropyl, or when R 2 is trifluoromethyl and R 1 is hydrogen, R 3 may be hydrogen; R 4 is isopropyl; R 5 is hydrogen or isopropyl; and n is one of the integers 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
90 words
A compound of the formula: ##STR4## in which R 1 is hydrogen, hydroxyl, alkoxy of 1 to 6 carbon atoms or halo; R 2 is hydrogen, halo or trifluoromethyl, with the proviso that R 2 is not hydrogen when R 1 is hydrogen; R 3 is isopropyl, or when R 2 is trifluoromethyl and R 1 is hydrogen, R 3 may be hydrogen; R 4 is isopropyl; R 5 is hydrogen or isopropyl; and n is one of the integers 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
14 words
The compound of claim 1 which is N-(1-methylethyl)-N-[3-(1-methylethylamino)propyl]-3-(trifluoromethyl)benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
14 words
The compound of claim 1 which is N-[3-[(1-methylethyl)amino]-propyl]-3-(trifluoromethyl)benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
The compound of claim 1 which is 3,4-dichloro-N-(1-methylethyl)-N-[3-(1-methylethylamino)propyl]-benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
14 words
The compound of claim 1 which is N-[4-[(1-methylethyl)amino]butyl]-3-trifluoromethyl)-benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
14 words
The compound of claim 1 which is N-(1-methylethyl)-N-[4-[(1-methylethyl)amino]butyl]-3-(trifluoromethyl)benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
14 words
The compound of claim 1 which is 3,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
14 words
The compound of claim 1 which is 4-hydroxy-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
14 words
The compound of claim 1 which is 4-methoxy-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
98 words
An anti-arrhythmic composition comprising an anti-fibrillating amount of a compound of the formula: ##STR5## in which R 1 is hydrogen, hydroxyl, alkoxy of 1 to 6 carbon atoms or halo; R 2 is hydrogen, halo or trifluoromethyl, with the proviso that R 2 is not hydrogen when R 1 is hydrogen; R 3 is isopropyl, or when R 2 is trifluoromethyl and R 1 is hydrogen, R 3 may be hydrogen; R 4 is isopropyl; R 5 is hydrogen or isopropyl; and n is one of the integers 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
98 words
An anti-arrhythmic composition comprising an anti-fibrillating amount of a compound of the formula: ##STR5## in which R 1 is hydrogen, hydroxyl, alkoxy of 1 to 6 carbon atoms or halo; R 2 is hydrogen, halo or trifluoromethyl, with the proviso that R 2 is not hydrogen when R 1 is hydrogen; R 3 is isopropyl, or when R 2 is trifluoromethyl and R 1 is hydrogen, R 3 may be hydrogen; R 4 is isopropyl; R 5 is hydrogen or isopropyl; and n is one of the integers 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
12 words
A pharmaceutical composition of claim 10 in which said compound is N-(1-methylethyl)-N-[3-(1-methylethylamino)propyl]-3-(trifluoromethyl)benzenesulfonamide.
Claim 14
Dependent Claim
12 words
A pharmaceutical composition of claim 10 in which said compound is N-[3-[(1-methylethyl)amino]propyl]-3-(trifluoromethyl)benzenesulfonamide.
Claim 15
Dependent Claim
12 words
A pharmaceutical composition of claim 10 in which said compound is N-[4-[(1-methylethyl)amino]butyl]-3-trifluoromethyl)-benzenesulfonamide.
Claim 16
Dependent Claim
12 words
A pharmaceutical composition of claim 10 in which said compound is N-(1-methylethyl)-N-[4-[(1-methylethyl)amino]butyl]-3-(trifluoromethyl)benzenesulfonamide.
References Cited (Backward Citations)
US2233296A
Cited
DE1912851A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-18 | 1991-07-20 | 1992-01-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-18 | 1995-07-20 | 1996-01-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-18 | 1999-07-20 | 2000-01-19 | $7700.00 | Window Closed / Lapsed |